Preparation method of clostridium bolteae surface capsular polysaccharide structure derivative

A technology for gram-positive bacteria and derivatives, applied in the field of carbohydrate chemistry, can solve the problems of long time, high cost, difficulty in vaccine preparation and the like
CN108329362AActive Publication Date: 2018-07-27JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2018-07-27

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Abstract

The invention discloses a preparation method of a clostridium bolteae surface capsular polysaccharide structure derivative and belongs to the field of sugar chemistry. The preparation method comprisesthe following steps: taking glucose as a glycosyl donor to obtain a target beta-glycosidic bond; then successfully synthesizing a disaccharide building block through an oxidization-reduction glucoseC-2 site method; then synthesizing a target oligosaccharide structure which takes the disaccharide building block as a repeating unit, such as the gram-positive bacterium surface capsular polysaccharide structure derivative [arrow3]-alpha-D-Manp-(1arrow4)-beta-D-Rhap-(1arrow]5-Linker. A reducing end of decaose is connected with a connecting arm and is used for connecting protein to form a glycoconjugate for carrying out immunology researches. The method provided by the invention has the advantages of simplicity, time saving, labor saving and low cost; the obtained clostridium bolteae surface capsular polysaccharide structure derivative is possibly used for developing and preparing medicine related to autism.
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Description

technical field

[0001] The invention relates to a preparation method of a capsular polysaccharide structure derivative on the surface of Gram-positive bacteria, belonging to the field of sugar chemistry. Background technique

[0002] Autism, also known as autism, was first discovered in clinical medicine by American psychiatrist Leo Kanner and put forward this concept in the late 1930s. The main manifestations of autism are children's socialization disorder, language communication disorder and behavior habit disorder. According to current international commonly cited standards, 1 in every 160 children suffers from autism. Based on this calculation, the number of children with autism in China was about 1.64 million in 2012, and it is increasing at a rate of 10% to 17% every year, reaching one thousandth of the population. Worldwide, autism has received more and more attention and attention. Since 2008, the United Nations General Assembly has designated April 2 as "World Au...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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