Two-photon fluorescent sodium ion probe and its synthesis method and application

A technology of two-photon fluorescence and synthesis method, which is applied in the field of two-photon fluorescence sodium ion probe and its synthesis, can solve the problems of inability to identify and detect specific ions, poor water solubility of the probe, and not reaching the ideal, so as to improve the clarity, cell Good permeability and short response time
CN108456192BActive Publication Date: 2020-08-14ZUNYI NORMAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZUNYI NORMAL COLLEGE
Publication Date
2020-08-14

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Abstract

The invention belongs to the technical field of fine chemical engineering, particularly relates to a dual-photon fluorescence sodium ion probe and a synthesis method and application thereof. The probeis prepared by using distyrene dicyanide as the parent of the dual-photon fluorescence. The probe has small molecule volume and good selectivity to sodium ions. Oher ions other than sodium ions suchas zinc, potassium, calcium, magnesium, manganese, mercury and the like have no interference to the detection. The sodium ions of micro-molar concentration can be detected. The fluorescence intensityof the probe molecular is reduced after complexation with sodium ions, and the sodium ion content can be detected by double-photon fluorescence. The double-photon fluorescence microscopic imaging experiment shows that the probe has good permeability to cells or tissues such as fibroblast, has no toxic and side effect on the cells, is particularly suitable for detecting the concentration change ofsodium ions in the cell and the detection of the distribution of the mercury ions, and has great application value in the field of biology and medicine.
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Description

technical field

[0001] The invention relates to the field of fine chemical industry, in particular to a two-photon fluorescent sodium ion probe and its synthesis method and application. Background technique

[0002] The development of the global economy has brought about the improvement of people's material living standards. But it also brings a lot of environmental problems, such as: pollution of metal ions. The detection and monitoring of metal ions is a hot issue in the field of biology and medicine. Previous detection methods for metal ions damaged cells to a certain extent and were not accurate enough. The development of metal ion fluorescent probes can realize the specific detection of metal ions, real-time detection under the fluorescence microscope, avoiding the damage to cells due to the injection of a large number of chemical reagents. Therefore, it is necessary to develop two-photon metal ion fluorescent probes with biocompatibility, specific structure and site...

Claims

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