A kind of preparation method and application of six-carbon monosaccharide selenite compound

A technology of six-carbon monosaccharide and selenite, which is applied in the preparation of sugar derivatives, esterified saccharides, chemical instruments and methods, etc. , bioavailability limitations and other issues, to achieve the effect of improving absorption capacity, good water solubility, and high selenization efficiency

Active Publication Date: 2022-07-05
湖南泽迈生物科技有限公司
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The preparation of this method is loaded down with trivial details, and the selenium content that obtains is also very low
However, the Chinese patent (publication number CN1288899A) discloses that the preparation of a polysaccharide selenite is achieved by replacing the polysaccharide sulfate group with nitrite radicals, resulting in the selenium content of the polysaccharide selenite being limited by the reaction conditions and also affected by the polysaccharide sulfuric acid. The sulfate ester group content of ester is controlled, and the selenium content that causes this method to prepare polysaccharide selenite is on the low side, and its maximum selenium content is 12.5%
Patent Publication No. CN101104644A generates polysaccharide selenite through the reaction of selenizing reagents and hydroxyl groups of sugar units, and the product yield is improved compared with other methods, but polysaccharide selenium is not good in water solubility and does not possess fat solubility. limited in bioavailability

Method used

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  • A kind of preparation method and application of six-carbon monosaccharide selenite compound

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Experimental program
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Effect test

Embodiment 1

[0039] (1) Selenization reaction: add 0.1 mol of pyranose to 50 mL of hydrochloric acid solution with a concentration of 5% by mass, then add 0.5 mol of potassium selenate, and place it in a continuous full-wave rectified microwave reactor. The technical parameters of the reactor are: input power supply voltage 220 V ± 5 % (50 Hz), full-wave rectification voltage: 3000 V ± 5 %; microwave frequency 2450 ± 5 MHz, microwave output power 800 W, reaction time is 3min, the reaction is completed After cooling down to room temperature naturally;

[0040] (2) Adjust pH: add ammonium chloride buffer solution to the reaction solution to make the pH of the solution neutral;

[0041] (3) Dialysis: use nanofiltration membrane dialysis;

[0042] (4) Freeze drying: The osmotic solution was placed in a freeze dryer and lyophilized under reduced pressure to obtain a six-carbon monosaccharide selenite powder. The detected selenium content was 61%.

Embodiment 2

[0044] (1) Selenization reaction: add 0.1 mol of pyranose to 50 mL of hydrochloric acid solution with a concentration of 10% by mass, then add 0.3 mol of selenium dioxide, and place it in a continuous full-wave rectified microwave reactor. The technical parameters of the reactor are: input power supply voltage 220 V ± 5 % (50 Hz), full-wave rectification voltage: 3000 V ± 5 %; microwave frequency 2450 ± 5 MHz, microwave output power 750 W, reaction time is 5min, the reaction After completion, cool down to room temperature naturally;

[0045] (2) Adjust pH: add ammonium chloride buffer solution to the reaction solution to make the pH of the solution neutral;

[0046] (3) Dialysis: use nanofiltration membrane dialysis;

[0047] (4) Freeze-drying: The osmotic solution was placed in a freeze-drying machine, and lyophilized under reduced pressure to obtain a six-carbon monosaccharide selenite powder. The detected selenium content was 50%.

Embodiment 3

[0049] (1) Selenization reaction: add 0.15mol fructose to 50mL of nitric acid solution with a concentration of 20% by mass, then add 0.1mol potassium selenate, and place it in a continuous full-wave rectifier microwave reactor. The technical parameters are: input power supply voltage 220 V ± 5 % (50 Hz), full-wave rectification voltage: 3000 V ± 5 %; microwave frequency 2450 ± 5 MHz, microwave output power 850 W, reaction time 3min, after the reaction is completed, Cool down to room temperature naturally;

[0050] (2) Adjust pH: add ammonium chloride buffer solution to the reaction solution to make the pH of the solution neutral;

[0051] (3) Dialysis: use nanofiltration membrane dialysis;

[0052] (4) Freeze drying: The osmotic solution was placed in a freeze dryer and lyophilized under reduced pressure to obtain a six-carbon monosaccharide selenite powder. The detected selenium content was 41%.

[0053] Raman spectrum of fructose selenite; Laser Raman spectrum of fructose ...

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Abstract

The invention discloses a preparation method and application of a six-carbon monosaccharide selenite compound. The preparation method uses a continuous full-wave rectification microwave reactor as a reactor. The reagents are selenized under the action of microwave to obtain six-carbon monosaccharide selenite compounds; the six-carbon monosaccharide selenite compounds have high selenium content, good water solubility and fat solubility, and good stability, and are more easily absorbed. It can be absorbed and utilized by the body, and can be widely used as a food nutritional fortifier or feed additive or veterinary drug, and the preparation method of the six-carbon monosaccharide selenite compound is simple, efficient, low-cost, and beneficial to industrial production.

Description

technical field [0001] The invention relates to the technical field of the synthesis of selenized monosaccharides, in particular to a preparation method and application of a six-carbon monosaccharide selenite compound. Background technique [0002] A six-carbon monosaccharide sugar containing six carbon atoms in the sugar molecule, such as glucose and fructose, is a type of carbohydrate. Its structure is the simplest among many sugar molecules, and it has a sweet taste and is soluble in water. [0003] Glucose is the most widely distributed and most important monosaccharide in nature, and it is a polyhydroxy aldehyde. Pure glucose is a colorless crystal with a sweet taste but not as sweet as sucrose (normal people cannot taste the sweetness), easily soluble in water, slightly soluble in ethanol, and insoluble in ether. The optical rotation of the aqueous solution is to the right, so it belongs to "dextrose". Glucose plays an important role in the field of biology. It is th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H11/00C07H1/00C07H19/00A23L33/16A23K20/20
CPCA23K20/30A23L33/16C07H1/00C07H11/00C07H19/00
Inventor 金晓飞
Owner 湖南泽迈生物科技有限公司
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