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Implant material for spinal repair and fixation and preparation method thereof

An implant material and spine technology, applied in the field of spine repair, can solve the problems of bone matrix gelatin inactivation, difficulty in compounding, lack of mechanical strength, etc.

Active Publication Date: 2021-05-11
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PEEK lacks biological activity and cannot form a strong bond with human bone
Bone matrix gelatin (BMG) is a mixture obtained through a series of physical and chemical treatments on the basis of demineralized bone matrix (DBM). It is a crude extract of bone morphogenetic protein and contains bone growth factors such as bone morphogenetic protein. , has strong osteoinductive activity, but lacks sufficient mechanical strength and is difficult to form
Compounding polyether ether ketone and bone matrix gelatin to prepare implant materials has great application value, but it is not easy to compound the two, and the preparation process will easily cause bone matrix gelatin to be inactivated and difficult to achieve medical purposes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: Implant material preparation one:

[0026] First prepare the polyetheretherketone / hydroxyapatite composite:

[0027] Hydroxyapatite powder pretreatment: After grinding 100g of hydroxyapatite powder to 20nm, the molecular structure and calcium-phosphorus ratio of hydroxyapatite are very similar to the inorganic components of normal human bones, and have a good biological phase with bones Capacitance and osteoconductivity, and the biological activity of nano-sized hydroxyapatite is high, mixed with 400ml 3wt% acetic acid and stirred for 10 minutes, after mixing evenly, let stand and age at 40°C for 30 minutes, acetic acid is less acidic, and hydroxyphosphorus Limestone is only slightly soluble in acetic acid solution. After aging at a temperature to prevent deactivation, the surface of hydroxyapatite crystals changes, the mechanical properties increase, and its toughness and strength increase. Vacuum filtration is performed after aging, and the filtered Was...

Embodiment 2

[0034] Embodiment 2: Implant material preparation two:

[0035] First prepare the polyetheretherketone / hydroxyapatite composite:

[0036] Hydroxyapatite powder pretreatment: After grinding 120g hydroxyapatite powder to 25nm, mix and stir with 450ml 4wt% acetic acid for 12min, after mixing evenly, stand and age for 35min at a temperature of 38°C, and carry out after the aging is completed Vacuum suction filtration, wash the filter cake until the washing liquid is neutral, dry at 60°C and grind again to 25nm;

[0037] Preparation of biological glass whisker intermediate: Disperse 45g of calcium nitrate tetrahydrate and 15g of triethyl phosphate in 900ml of absolute ethanol, heat in a water bath at 30°C for 1h, add 180g of tetraethyl orthosilicate, stir well and then add 4wt % hydrochloric acid solution, stirred at a rate of 100r / min for 5h, left to age at room temperature until a gel was formed, dried at 150°C for 3h to obtain a xerogel, and the xerogel was ground and sieved G...

Embodiment 3

[0041] Embodiment 3: Implant material preparation three:

[0042] First prepare the polyetheretherketone / hydroxyapatite composite:

[0043] Hydroxyapatite powder pretreatment: after grinding 80g of hydroxyapatite powder to 30nm, mix and stir with 200ml of 5wt% acetic acid for 15min, after mixing evenly, stand and age for 40min at a temperature of 35°C, and carry out after the aging is completed Vacuum suction filtration, wash the filter cake until the washing liquid is neutral, dry at 60°C and grind again to 30nm;

[0044] Preparation of biological glass whisker intermediate: Disperse 45g of calcium nitrate tetrahydrate and 15g of triethyl phosphate in 900ml of absolute ethanol, heat in a water bath at 30°C for 1h, add 180g of tetraethyl orthosilicate, stir well and then add 4wt % hydrochloric acid solution, stirred at a rate of 100r / min for 5h, left to age at room temperature until a gel was formed, dried at 150°C for 3h to obtain a xerogel, and the xerogel was ground and si...

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Abstract

The invention discloses an implant material for spinal repair and fixation and a preparation method thereof, belonging to the technical field of spinal repair. The implant material is based on a polyether ether ketone / hydroxyapatite compound and a bone matrix Gelatin is a macroporous composite material with an active component, the pore diameter of the implant material is 1-3 μm, the porosity is 20-30%, the content of the active component is 10-20%, and the polyether ether ketone / The hydroxyapatite complex contains biological glass whiskers. The object of the present invention is to provide an implant material for spinal repair and fixation and a preparation method thereof. The implant material of the present invention can not only provide support, but also have better biocompatibility with bone tissue. The implant material Bone matrix gelatin is added as an active component. During the preparation of the implant material, the active component remains active and stimulates bone tissue regeneration and accelerates healing after use.

Description

technical field [0001] The invention relates to the technical field of spinal repair, in particular to an implant material for spinal repair and fixation and a preparation method thereof. Background technique [0002] With the continuous development of modern medicine and tissue engineering, the clinical application of spinal implants has become a major direction of modern spinal disease treatment. Spinal implants are divided into static fixation systems (such as pedicle screws, steel plates, intervertebral fusions, etc.) and dynamic fixation systems (such as artificial intervertebral discs, artificial nucleus pulposus, etc.) according to their functional characteristics after insertion. In addition to using your own bones for spinal implants, spinal implants made of metal materials such as stainless steel, cobalt-based alloys, and titanium alloys have gradually been widely used clinically. [0003] Among medical metal materials, titanium and titanium alloys are considered ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/48A61L27/50A61L27/54A61L27/56
CPCA61L27/48A61L27/50A61L27/54A61L27/56A61L2300/412A61L2430/38C08L61/16C08L89/00C08L5/08C08L67/04
Inventor 徐海涛
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV