A kind of composite material containing bioactive glass coating and its preparation method and application

Abstract

The invention discloses a composite material containing a bioactive glass coating, a preparation method and an application thereof. The method comprises the following steps: forming the bioactive glass coating by guiding calcium to enter into a network of bioactive glass under lower temperature (less than or equal to 60 DEG C) in a bioactive glass sol taking calcium methoxyethanol as a calcium precursor, and then compounding the bioactive glass coating with a base material. The bioactive glass exists in the form of coating, is uniformly distributed, can be in direct contact with body fluid andis capable of fully utilizing the bioactivity thereof; the bioactive glass is free from the problems of uneven distribution and embedding of bioactive glass of the traditional direct blended bioactive glass particle and base material; the composite material is capable of keeping the original form, bore diameter and porosity of the base material; the composite material is beneficial to promoting mechanical properties of the polymer base material; the composite material shows excellent cytocompatibility, has a certain proliferation-boosting effect to cells and has a bright application prospectin the field of repairing and regeneration of tissues of human body.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a composite material containing a bioactive glass coating, a preparation method and application thereof. Background technique [0002] Bioactive glass (BG) is a biomaterial with good bioactivity, biocompatibility and degradability, and has great application prospects in the field of tissue repair. After implanted in the body, BG can release some ions that induce bone tissue and blood vessel growth, such as silicon ions, calcium ions, etc., thereby promoting tissue repair. In addition, in the body fluid environment, BG can form a hydroxyapatite (Hydroxyapatite, HA) layer on its surface that is similar to bone tissue composition, form a firm chemical bond with the surrounding hard or soft tissue, and induce tissue repair and regeneration. By introducing BG coating, the affinity between implanted medical materials and surrounding tissues can be greatly impr...

AI Technical Summary

Problems solved by technology

However, in order to remove toxic nitrate radicals and allow calcium to enter the silicate network of BG when preparing BG by traditional sol-gel method, high temperature treatment (>500 °C) is usually required, which limits its application on heat-labile material substrates. applications such as polymer

Moreover, the BG particle dispersion system is used as the raw material, which may easily cause the problem of non-fusion of BG particles in the coating and uneven coating

Moreover, the preparation of bioactive glass coating by sol-gel method takes a long time after treatment, and the coating is prone to cracking, the bonding strength between the coating and the base is low, and the process is complicated, the production efficiency is low, and it is not suitable for large-scale industrial production.

[0003] There are many traditional methods for preparing bioactive glass coatings, such as powder metallurgy sintering method, acid-base treatment method, laser cladding method, pulsed laser deposition method, magnetron sputtering method, electrophoretic deposition method and powder plasma spraying method, These methods can be well applied to the surface coating of metal materials (such as titanium alloys), and are not used for polymer-based composite materials; and considering the application field of composite materials, for composite materials with heterogeneous structures, such as spray coating, pulse Methods such as laser deposition and magnetron sputtering are not applicable, and they cannot achieve uniform coating on the surface of composite materials with heterogeneous structures.

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