Application of semiconductor nano photosensitive material in preparing visual repair material

A technology for repairing materials and photosensitive materials, which can be used in prosthesis, medical science, tissue regeneration, etc. It can solve the problems of disappearance, affecting the treatment effect, visual degradation, etc., and achieves a large interaction area, large charge mobility, and high specific surface area. Effect

Active Publication Date: 2019-08-09
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Degenerative diseases of the retina, such as retinitis pigmentosa and macular degeneration, can lead to damage or complete loss of photoreceptor cells, which can lead to visual deterioration or even complete blindness
[0003] The current clinical solutions for retinal degenerative diseases include: the application of retinal prosthesis devices, that is, placing an external near-infrared signal detector on the head, and placing a photodiode array under the retina to receive the external signal detector The collected signal relieves the symptoms of retinal degenerative diseases. However, clinical practice shows that the signal collected by the detector is often unable to maintain stability due to head movement, which has always affected the therapeutic effect
Therefore, photosensitive materials that can be used as artificial photoreceptors are becoming a research hotspot in this field, but the existing photosensitive materials have the following defects, such as the need for additional microelectronic processing for signal generation, conduction and processing, etc. It directly limits the application in vivo
[0004] Some studies have reported the preparation of photoelectrochemical sensing materials and nanowire array composite materials, etc., but so far there has been no report on the use of photosensitive semiconductor nanomaterials for the preparation of visual repair materials. Based on the current state of the art, this application The inventor intends to provide new uses of semiconductor nanomaterials with photosensitivity, specifically related to the use of semiconductor nanophotosensitive materials in the preparation of visual repair materials, which can be used for visual repair of visual defects

Method used

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  • Application of semiconductor nano photosensitive material in preparing visual repair material
  • Application of semiconductor nano photosensitive material in preparing visual repair material
  • Application of semiconductor nano photosensitive material in preparing visual repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Material preparation:

[0026] TiO 2 Fabrication of nanowires: TiO nanowires were grown vertically on fluorine-doped tin oxide (FTO)-coated glass or polymethylsiloxane (PDMS) by a hydrothermal method. In a typical synthesis, 0.1 g of titanium foil and 18 ml of 0.1 M HCl solution were placed in a Teflon-lined stainless steel reaction vessel. Afterwards, after 30 minutes of ultrasonic cleaning, the PDMS was immersed in a 1:1:1 (v / v) mixed solution of acetone, ethanol and deionized water (DI), and hydrothermal synthesis was performed at 150°C for 12 hours in an electric oven;

[0027] Au-TiO 2 Nanowire Synthesis: On TiO 2 After the nanowires were prepared, the TiO 2 Au nanoparticles were deposited on the nanowires. Briefly, FTO substrates with TiO nanowires were soaked into 0.01M HAuCl 4 solution (adding 0.2M NaOH to adjust the pH value to 4.5) for 2h. Afterwards, the samples were thoroughly rinsed with deionized water, air-dried, and annealed at 300°C for 2 hours; ...

Embodiment 2

[0029] Embodiment 2 in vitro test

[0030] The application of the prepared repair material in the isolated retina and the recording of the light response: the mice used in this example are rd1-cDTA transgenic mice aged 8-12 weeks, and the wild-type mice are 8-12 weeks old. C57B1 / 6 mice at the age of one week; when testing the visual repair effect of the material on the isolated retina, the outer layer and area of ​​​​the retina of the blind mouse that was quickly removed and remained active was about 1 cm 2 The materials were closely attached, and the retinal ganglion cell layer was placed upwards, placed in the incubation tank, and the patch clamp technique was used to perform whole-cell recording of the ganglion cells with experimental methods known in the art. Blind mice and wild-type small For mice, put the removed retina directly in the incubation tank for whole-cell recording; the light stimulation mode is usually near ultraviolet light, blue light or green light, and th...

Embodiment 3

[0032]The prepared prosthetic material was applied to test mice and the light reaction was recorded: the area was about 0.5-1.5mm 2 Implant the material between the retina and the pigment epithelium of the blind mouse eye, and after at least 2 days of operation recovery period, apply the electrophysiological technique in vivo to the contralateral visual cortex of the implanted eye with the experimental operation method known in the art. Light response recording: When recording, the head of the mouse was fixed, a skylight was opened in the appropriate area of ​​the skull, electrodes were inserted into the visual cortex, the light source was aimed at the implanted eye, and the light response of neurons in the contralateral visual cortex was recorded. Blind mice and wild-type mice were directly subjected to in vivo electrophysiological recordings; the light stimulation mode was often near-ultraviolet light, and the light-giving time was usually 1s; Cortical neurons did not signif...

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Abstract

The invention belongs to the technical field of semiconductor nano photosensitive materials, and relates to novel application of a semiconductor nanomaterial with a photosensitive effect, in particular to the application of a semiconductor nano photosensitive material in preparing a visual repair material. The semiconductor nano photosensitive material is similar to a retinal photoreceptor cell and is an ordered one-dimensional gold-modified titanium oxide nanowire array; the semiconductor nano photosensitive material has the advantages of high specific surface area, large material retinal interaction area, large charge mobility and good biocompatibility and stability, and is applied to both isolated retina and a living mouse by replacing a photoreceptor, so that the retina produces a photoreaction; the semiconductor nano photosensitive material can be used for preparing the visual repair material for repairing dysopia. Experiments confirm that the visual repair material can repair retinal ganglion cells to produce the photoreaction, thereby repairing visual cortical nerve cells to produce the photoreaction.

Description

technical field [0001] The invention belongs to the technical field of semiconductor nano photosensitive materials, and relates to a new application of a photosensitive semiconductor nano material, in particular to the application of the semiconductor nano photosensitive material in the preparation of visual repair materials, which can be used for visual repair of visual defects. Background technique [0002] The prior art discloses that the retina is an important photoreceptor organ, and the light signal can be converted into an electrical signal by its photoreceptor cells, and transmitted from the inner retinal cells to the retinal ganglion cells, and then transmitted to the higher optic center through the optic nerve. Degenerative retinal diseases, such as retinitis pigmentosa and macular degeneration, can cause photoreceptor cells to be damaged or even disappear completely, which in turn can lead to visual deterioration or even complete blindness. [0003] The current cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/04A61L27/10A61L27/50
CPCA61L27/025A61L27/047A61L27/50A61L27/10A61L2430/16A61L2400/12
Inventor 张嘉漪唐静秦楠种颜郑耿锋
Owner FUDAN UNIV
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