Radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof

A technology of temperature-sensitive nano and nano-materials, applied in the field of radio-frequency response temperature-sensitive nano-composite embolic materials and its preparation, can solve the problems of poor synergy and small ablation area, achieve high fluidity, smooth injection process, and improve thermal deposition Efficiency and Distribution Effects

Active Publication Date: 2019-08-16
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, the recently developed RF-responsive nanomaterials (such as gold nanoclusters, carbon nanotubes, graphene, cobalt nanoparticles, etc.) utilize the excellent tissue penetration ability of RF electromagnetic waves to achieve efficient thermal deposit

Method used

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  • Radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof
  • Radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof
  • Radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof

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Experimental program
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Effect test

Embodiment 1

[0045] The preparation of embodiment 1 thermosensitive nanometer polymer

[0046] The present embodiment adopts atom transfer radical polymerization (ATRP) to prepare temperature-sensitive nanopolymer, specifically comprises the following steps:

[0047] (1) Synthesis of polymer p(NIPAM400-co-tBAx) (i.e. synthesis of PNtBx)

[0048] Taking the synthesis of polymer PNA20 as an example, the specific reaction steps are as follows: Accurately weigh monomer NIPAM (11.3g, 100mmol) and add it to a Stokes reaction tube equipped with a magnetic stirrer; accurately pipette acetone (16.0mL ) and ultrapure water (4.0mL) into the reaction tube, stirred on a constant temperature magnetic stirrer to completely dissolve NIPAM, transferred to a liquid nitrogen bath to freeze for 4 minutes, vacuum pumped for 5 minutes, stirred in a hot water bath and introduced argon for 5 minutes ; Add initiator BiBOEDS (80 μL, 0.25 mmol), cosolvent Me6TREN (135 μL, 0.50 mmol) and monomer tBA (735 μL, 5.00 mm...

Embodiment 2

[0057] Example 2 Preparation of RF-responsive temperature-sensitive nanocomposite embolic material

[0058] The embodiment of the present invention prepares the radio frequency responsive temperature-sensitive nanocomposite embolic material using the PNA prepared in Example 1 20 As temperature-sensitive nanopolymers, the sources of RF-responsive nanomaterials are as follows: gold nanoclusters (GC) were prepared by the glutathione reduction method, gold nanoparticles and cobalt nanoparticles were prepared by the traditional sodium citrate reduction method, divalent Platinum ions, tetravalent platinum ions, carbon nanotubes, and graphene are commercially available products.

[0059] The specific experimental method of preparing gold nanocluster GC with a particle size of <10nm by glutathione reduction method is as follows: use a 500mL single-necked round-bottom flask used for repeated ultrasonic washing reactions with freshly prepared aqua regia, add 380mL The newly prepared ul...

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Abstract

The invention discloses a radio frequency response thermosensitive nano-composite embolization material and preparation and application methods thereof. The radio frequency response thermosensitive nano-composite embolization material is in a core-shell structure composed of a radio frequency response nano material core and thermosensitive nano polymers with the molecular chains modified onto thesurface of the core. The preparation method of the radio frequency response thermosensitive nano-composite embolization material comprises weighing out and mixing thermosensitive nano polymer freeze-dried powder with radio frequency response nano materials for self-assembly reaction, performing ultrafiltration and centrifugation, and then collecting and freeze-drying concentrated solution to obtain the radio frequency response thermosensitive nano-composite embolization material. With the characteristic of radio frequency response, the radio frequency response thermosensitive nano-composite embolization material can improve the thermal deposition efficiency and distribution of abundant blood supply tumor areas, give full play to the multiple chemotherapeutic sensitizing effects of thermaltherapy and achieve the synergistic effects of radio frequency thermal therapy, chemotherapy and vascular embolization; the radio frequency response thermosensitive nano-composite embolization material can serve as an embolization agent for embolotherapy as well as a radio frequency response material, achieve intraoperative X-ray developing and long-term postoperative X-ray re-examination, and accordingly have a broad application prospect in the fields such as nanomedicine, disease diagnosis and tumor treatment.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and in particular relates to a radio frequency response temperature-sensitive nanocomposite embolic material and its preparation method and application. Background technique [0002] Due to its insidious onset, rapid invasion and metastasis, and high degree of malignancy, primary liver cancer has become one of the most serious public health problems in my country, and its 5-year survival rate is less than 5%. The clinical efficacy is very limited. At present, interventional therapy is one of the most important treatment methods for advanced liver cancer; in particular, transarterial chemoembolization (TACE) can achieve targeted delivery of vascular embolism agents and chemotherapy drugs in peripheral arteries through superselective perfusion (one of the most efficient targeting strategies), and is recommended as the preferred interventional therapy for liver cancer. [0003] Howe...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/02A61L24/06A61K9/50A61K47/32A61K31/407A61K31/513A61K31/704A61K33/243A61K41/00A61P35/00
CPCA61K9/5026A61K31/407A61K31/513A61K31/704A61K33/243A61K41/0052A61L24/001A61L24/0015A61L24/02A61L24/06A61L2430/36A61P35/00A61K2300/00C08L33/24C08L33/08
Inventor 赵彦兵杨祥良李玲赵浩彭晓乐史鼎文
Owner HUAZHONG UNIV OF SCI & TECH
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