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Iodine-loaded bioactive glass for wound care and application of iodine-loaded bioactive glass

A bioactive glass, wound care technology, applied in the medical and health field to achieve long-lasting antibacterial efficacy, rapid repair and broad-spectrum regeneration

Inactive Publication Date: 2019-08-23
ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect of prior art, in order to solve the persistent problem of antibacterial property of bioactive glass, propose a kind of iodine-loaded bioactive glass and its application for wound care

Method used

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  • Iodine-loaded bioactive glass for wound care and application of iodine-loaded bioactive glass
  • Iodine-loaded bioactive glass for wound care and application of iodine-loaded bioactive glass

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 0.6g chitosan was added to 20ml 2% glacial acetic acid aqueous solution to prepare 3% chitosan aqueous solution, and 40ml ethanol was added. Add 12.5g ethyl orthosilicate and 8.5g calcium nitrate tetrahydrate to the above ethanol aqueous solution, adjust the pH value to 1-2, stir for 30min, and obtain transparent and uniform sol solution A. Dissolve 1.056 g of diammonium hydrogen phosphate and 2.5 g of PEG in 50 ml of deionized water to obtain a clear and transparent solution B. Slowly add the sol solution A to the solution B dropwise, stir for 30 minutes, slowly add 28% ammonia water dropwise therein under constant stirring, and adjust the pH to 10-11 after a milky white precipitate appears. Centrifuge, freeze-dry, and heat-treat at 600-800°C in a muffle furnace for 3 hours to obtain hollow bioactive glass powder.

Embodiment 2

[0036] 0.5g chitosan was added into 20ml 2% boric acid aqueous solution to prepare 2.5% chitosan aqueous solution, and 40ml ethanol was added. Add 10.42g of tetraethyl orthosilicate and 10.86g of calcium nitrate tetrahydrate to the above aqueous ethanol solution, adjust the pH value to 1-2, stir for 30min, and obtain a transparent and uniform sol solution A. Dissolve 1.056 g of diammonium hydrogen phosphate in 20 ml of deionized water, add 1 g of PVA, and stir until it is completely dissolved to obtain a clear and transparent solution B. Slowly add the sol solution A to the solution B, stir for 30 minutes, drop 1.5mol / L NaOH solution drop by drop under constant stirring, wait until the pH reaches 10-11, after the reaction is complete, centrifuge to obtain a white precipitate, which is freeze-dried 1. High-temperature heat treatment at 600° C. for 3 hours in a muffle furnace to obtain hollow bioactive glass powder.

Embodiment 3

[0038] Put the hollow bioactive glass into a vacuum drying oven, and dry it under vacuum at 100°C for 1 hour; seal the iodine particles and grind them into fine powder; weigh the iodine and the bioactive glass according to the mass ratio of 0.5:1, and vortex mix them for 5-10 minutes to make a mixture; Weigh 1g of the mixture into a 5ml glass ampoule and fill it with N 2 Gas, melt seal; place the drug-loaded ampoule in a temperature-controlled heater, set the temperature at 60°C and heat for 90 minutes; take the sample out of the ampoule, and pass through a 200-mesh sieve to obtain iodine-loaded bioactive glass.

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Abstract

The invention discloses iodine-loaded bioactive glass for wound care and application of the iodine-loaded bioactive glass. The properties that chitosan is not dissolved in an alkaline medium and formscondensation / precipitation when meeting an alkaline medium are utilized to obtain a chitosan microsphere template, and hollow bioactive glass is prepared from a compound containing various inorganicelements (silicon, calcium, sodium, phosphorus and the like) through a sol-gel-template method. The iodine-loaded bioactive glass is prepared by adopting a sealing temperature control sublimation andadsorption technology, and the composition has both bioactive glass particles and iodine molecules, can effectively promote healing of hard and soft tissue injuries of the human body, can also play along-lasting role of inhibiting / killing bacteria, has strong effects, low toxic and side effects and little immune inflammation response, and is convenient to store, carry and use.

Description

technical field [0001] The invention belongs to the field of medical and health technology, and in particular relates to a material for wound care and its application. Background technique [0002] In daily life, due to various reasons such as trauma, traffic accidents, sports injuries, surgery and congenital deformities, it is easy to cause various tissue defects. The self-healing of tissue wounds is too slow and the wound cannot heal in time. Various pathogenic microorganisms and chemical pollutants from the outside will enter through the wound, resulting in loss of body fluids and wound infection, and even endangering the life of the injured. Excessive bacterial colonies in the lesion will produce a high concentration of bacterial waste, resulting in chronic inflammation and more exudate, increasing tissue necrosis and expanding the infected area. When the number of bacteria burdened per gram of tissue is greater than 10 5 When it is left or right, its wound (ulcer surf...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61P17/02A61P31/00A61P31/02A61P31/04A61P31/10A61P1/02A61K33/00
CPCA61K33/00A61K33/18A61P1/02A61P17/02A61P31/00A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 黄娟王建伟彭贵宾陆涛
Owner ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY
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