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Preparation method of double-network chitosan hydrogel

A dual network, chitosan technology, applied in the field of chitosan hydrogel, can solve the problems of electrostatic interaction damage, hydrogel cytotoxicity, hydrogel network disintegration, etc., achieve good mechanical strength, expand in-depth research and practice applied effect

Inactive Publication Date: 2019-09-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been a large number of reports using physical cross-linking agents including sodium citrate (Carbohydrate Polymers, 2017, 168, 147-152), sodium tripolyphosphate (Biomacromolecules, 2014, 15, 3396-3405), sodium sulfate (Advanced Materials , 2018, 30, 1-9), sodium hexametaphosphate (Journal of Applied Polymer Science, 2010, 117, 3595-3600), trisodium 6-glucose phosphate (Biomacromolecules, 2018, 19, 1294-1304) etc. to prepare chitosan Sugar hydrogels, however, electrostatic interactions are easily disrupted by the influence of ionic strength, pH, etc., resulting in the disintegration of the hydrogel network
The coordination of transition metal ions with amino groups also faces the same disadvantage, and excess metal ions may lead to the potential cytotoxicity of hydrogels.

Method used

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  • Preparation method of double-network chitosan hydrogel
  • Preparation method of double-network chitosan hydrogel
  • Preparation method of double-network chitosan hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Pour 4.208ml of vinyltriethoxysilane into 30ml of deionized water and stir at room temperature for 12 hours to obtain a clear and transparent suspension of silica nanoparticles for use. Take 1ml of the above suspension, add it to 14ml deionized water, add 1.5g chitosan, 3g acrylamide, 94.6mg I2959, stir well, and place it at room temperature for 12 hours to eliminate air bubbles. The mixed solution was poured into a mold and subjected to ultraviolet light for 30 minutes to obtain a semi-interpenetrating network chitosan hydrogel. This hydrogel is soaked in 2mol / L saline solution (this saline solution can select potassium carbonate solution, sodium sulfate solution, dipotassium hydrogen phosphate trihydrate solution, sodium thiosulfate solution, sodium succinate solution, sodium citrate solution , sodium dihydrogen phosphate solution, and in the present embodiment preferred potassium carbonate solution) in 12h, obtain double network chitosan hydrogel. figure 1 It is a s...

Embodiment 2

[0029] Pour 4.208ml of vinyltriethoxysilane into 30ml of deionized water and stir at room temperature for 12 hours to obtain a clear and transparent suspension of silica nanoparticles for use. Take 1ml of the above suspension, add it to 14ml deionized water, add 0.6, 1.05 or 1.5g chitosan, 3g acrylamide, 94.6mg I2959, stir well, and place it at room temperature for 12 hours to eliminate air bubbles. The mixed solution was poured into a mold and subjected to ultraviolet light for 30 minutes to obtain a semi-interpenetrating network chitosan hydrogel. The hydrogel was soaked in 2mol / L potassium carbonate solution for 12 hours to obtain double network chitosan hydrogel. Image 6It shows that with the increase of the concentration of chitosan, the tensile strength of the double network hydrogel is obviously enhanced, which is mainly due to the rapid increase of the number of amino groups inside the hydrogel with the increase of the concentration of chitosan. The root ions formed ...

Embodiment 3

[0031] Pour 4.208ml of vinyltriethoxysilane into 30ml of deionized water and stir at room temperature for 12 hours to obtain a clear and transparent suspension of silica nanoparticles for use. Take 1ml of the above suspension, add it to 14ml deionized water, add 1.5g chitosan, 3g acrylamide, 94.6mg I2959, stir well, and place it at room temperature for 12 hours to eliminate air bubbles. The mixed solution was poured into a mold and subjected to ultraviolet light for 30 minutes to obtain a semi-interpenetrating network chitosan hydrogel. Soak the hydrogel in 0.5, 1.0, 1.5 or 2 mol / L potassium carbonate solution for 12 hours to obtain double network chitosan hydrogel. Figure 7 It shows that as the concentration of carbonate ions gradually increases, the tensile strength of the double network hydrogel tends to increase. When the concentration of carbonate is low, the difference in osmotic pressure between the inside and outside of the hydrogel is small. When water molecules ent...

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Abstract

The invention discloses a preparation method of double-network chitosan hydrogel. The preparation method comprises the steps: (1) adding vinyl triethoxysilane to deionized water, and performing stirring at room temperature so as to obtain a vinyl-modified silica nanoparticle suspension; (2) taking the silica nanoparticle suspension prepared in the step (1), adding deionized water, chitosan, acrylamide and I2959, and then performing ultraviolet light illumination so as to obtain semi-interpenetrating network chitosan hydrogel; and (3) immersing the semi-interpenetrating network chitosan hydrogel prepared in the step (2) in a salt solution so as to obtain double-network chitosan hydrogel finally. Nano particles and anions are adopted as cross-linking agents, and the chitosan hydrogel with good mechanical properties including high strength and toughness and anti-swelling properties is prepared through a simple process.

Description

technical field [0001] The invention relates to the technical field of chitosan hydrogel, in particular to a preparation method of double-network chitosan hydrogel. Background technique [0002] Chitosan is a linear natural polysaccharide that has been deacetylated by chitin and is connected by glucosamine and N-acetylglucosamine units through β-(1-4) glycosidic bonds. Chitosan has good water solubility, biocompatibility and degradability, and the molecular chain contains a large number of active amino groups. Due to the above advantages, chitosan is widely used in wound dressings, tissue engineering, sustained release of drugs or growth factors, biosensors or actuators, heavy metal ion adsorption and other fields. In the past few decades, scientists have adopted a variety of methods to prepare chitosan hydrogels. A large number of amino groups and hydroxyl groups on the chitosan molecular chain serve as reactive sites, which can be used with various organic small molecule...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L33/26C08K9/06C08K3/36
CPCC08J3/075C08J2305/08C08J2433/26C08K3/36C08K9/06C08K2201/011
Inventor 张鸣生谷恒曹晓东
Owner SOUTH CHINA UNIV OF TECH
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