Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation facilitating wound healing and preparation method of preparation

A wound healing and penetration enhancer technology, applied in the field of medicine, can solve the problems of low solubility of tofacitinib, difficult to achieve therapeutic effect, and aggravate wound infection, so as to promote drug absorption, prevent bacteria from entering the wound surface, and prevent wound infection. Effect

Pending Publication Date: 2019-10-25
瑞希(重庆)生物科技有限公司
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Tofacitinib is a JAKs inhibitor, which reduces cytokine signal transduction, cytokine-induced gene expression and cell activation by inhibiting the JAKs pathway, thereby reducing a variety of chronic inflammatory responses. It can be used for anti-inflammatory skin wounds, but Tofacitinib The solubility of tini is small, and it is difficult to achieve the therapeutic effect. Therefore, it is necessary to increase the content of tofacitinib or to enhance its transdermal penetration effect through a transdermal enhancer. In the prior art, transdermal enhancement such as 8% dimethyl sulfoxide is added. Drugs can enhance the transdermal penetration of tofacitinib, but the skin penetration enhancer will cause skin damage, which may aggravate wound infection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation facilitating wound healing and preparation method of preparation
  • Preparation facilitating wound healing and preparation method of preparation
  • Preparation facilitating wound healing and preparation method of preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation for promoting wound healing, by weight percentage, the preparation comprises the following components: viscosity is 50mPa·s, molecular weight is 15% of polydimethylsiloxane 3800, tofacitinib 0.2%, corticosteroid ( Dexamethasone) 1.5%, acceptable excipients in external skin preparations [moisturizing agent (glycerol) 5%, emollient (palm oil) 6%, penetration enhancer (isopropyl myristate) 2%, Antioxidant (tocopherol) 2%] 15%, balance is purified water. The preparation is prepared as follows:

[0029] (1) According to the weight percent of each component in the above-mentioned preparation, take by weighing viscosity is 50mPa·s, molecular weight is polydimethylsiloxane, tofacitinib, corticosteroid (dexamethasone), humectant ( glycerol), emollient (palm oil), penetration enhancer (isopropyl myristate), antioxidant (tocopherol) and purified water;

[0030] (2) dissolving tofacitinib, corticosteroid, humectant, emollient and penetration enhancer in purified wat...

Embodiment 2

[0033] A preparation for promoting wound healing, by weight percentage, the preparation comprises the following components: viscosity is 100mPa·s, molecular weight is 20% of polydimethylsiloxane 6000, tofacitinib 0.3%, corticosteroid ( triamcinolone acetonide) 1.0%, acceptable excipients in external skin preparations [stabilizer (carboxymethylcellulose) 2%, humectant (polyethylene glycol) 9%, emollient (caprylic capric triglyceride) 8%, penetration enhancer (PEG-200) 3%, antioxidant (ascorbic acid) 3%] 25%, and the balance is purified water. The preparation is prepared as follows:

[0034] (1) According to the weight percentage of each component in the above preparation, it is said that polydimethylsiloxane, tofacitinib, corticosteroid (triamcinolone acetonide), stabilizer (carboxylate) with a viscosity of 100 mPa·s and a molecular weight of 6000 methylcellulose), humectant (polyethylene glycol), emollient (caprylic capric triglyceride), penetration enhancer (PEG-200), antiox...

Embodiment 3

[0038] A preparation for promoting wound healing, by weight percentage, the preparation comprises the following components: viscosity is 30mPa·s, molecular weight is 10% of polydimethylsiloxane 3000, tofacitinib 0.2%, corticosteroid ( Budesonide) 1.7%, acceptable excipients in external skin preparations [stabilizer (xanthan gum) 3%, humectant (1,3-butanediol) 8%, emollient (lanolin) 5%, Penetration enhancer (laurocapram) 3%, antioxidant (sodium sulfite) 5%] 24%, and the balance is purified water. The preparation is prepared as follows:

[0039] (1) According to the percentage by weight of each component in the above-mentioned preparation, take the polydimethylsiloxane, tofacitinib, corticosteroid (budesonide), stabilizer ( xanthan gum), humectant (1,3-butanediol), emollient (lanolin), penetration enhancer (laurozone), antioxidant (sodium sulfite) and purified water;

[0040] (2) dissolving tofacitinib, corticosteroid, stabilizer, humectant, emollient and penetration enhancer...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Viscosityaaaaaaaaaa
Viscosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to a preparation facilitating wound healing and a preparation method of the preparation, and belongs to the technical field of medicines. The preparation comprises siloxane substrates, JAKs (Janus kinase) inhibitors, corticosteroid, acceptable accessories in skin external preparations and water. The preparation has the advantages that the preparation facilitates scars to be healed, restrains wound infection, prevents scar formation, and the like. The JAKs inhibitors and the corticosteroid are combined, an inflammation signal pathway is restrained, proinflammatory cytokinesignal transduction is interfered, better treatment effect can be acquired, a formula of the preparation is optimized, percutaneous absorption of functional medicines in the preparation can be facilitated, moist environments of a wound and the periphery of the wound can be kept, wound secretion can be effectively absorbed, compatibility between the preparation and a human body is good, safety ishigh, the preparation can prevent bacteria from entering the wound, secondary infection is prevented, wound healing is facilitated, and scar formation is prevented. The preparation is low in cost andsuitable for scale production, and a preparation process of the preparation is simple.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation for promoting wound healing and a preparation method thereof. Background technique [0002] Scar tissue refers to fibrous connective tissue in the aging stage formed by remodeling and maturation of granulation tissue. In situations such as trauma, fibroblasts divide, proliferate, migrate to the damaged site, produce extracellular matrix, and form scar tissue, thereby repairing the wound. Its formation is a process of gradual fibrosis of granulation tissue. At this time, there are more and more reticular fibers and collagen fibers, reticular fibers are collagenized, and collagen fibers become thicker. At the same time, fibroblasts are less and less, and a small amount of remaining Transform into fibroblasts; the fluid in the interstitium is gradually absorbed, and neutrophils, macrophages, lymphocytes, and plasma cells disappear successively; capillarie...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/06A61K31/519A61K31/573A61K31/58A61K47/34A61P17/02A61P29/00
CPCA61K31/519A61K31/573A61K31/58A61K45/06A61K47/34A61P17/02A61P29/00A61K2300/00
Inventor 冯文学李杨洪
Owner 瑞希(重庆)生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com