Control method for oxidation prevention of vitamin C tablet

Abstract

The invention relates to the technical field of vitamin C tablets and particularly provides a control method for oxidation prevention of a vitamin C tablet. A production process of the vitamin C tablet comprises the following steps that S1, vitamin C microcapsules are prepared; S2, 70-85 parts of the vitamin C microcapsules and a certain quantity of auxiliary materials are weighed, and all the rawmaterials are crushed to be sieved by a 60-mesh sieve; S3, all the raw materials are mixed evenly to obtain a mixed material; and S4, the mixed material is subjected to direct pressing forming undera certain tabletting environment. The auxiliary materials include cyclohexanediamine tetraacetic acid, pregelatinized starch, a lactose-starch complex, histidine, lysine and medically acceptable organic acid or inorganic acid. The vitamin C microcapsules are treated and then subjected to direct tabletting treatment, oxidation of a vitamin C in the wet granulation process is avoided, the other auxiliary materials are added to further inhibit oxidation of the vitamin C, and the stability of the vitamin C tablet is improved.

Description

technical field [0001] The invention relates to the technical field of vitamin C tablets, in particular to a method for controlling oxidation resistance of vitamin C tablets. Background technique [0002] Vitamin C, also known as ascorbic acid, is one of the vitamins that the human body needs more. If there is a lack of vitamin C, the human body is prone to scurvy, and vitamin C cannot be synthesized in the human body, so it needs to rely on food supply. Vitamin C tablets are a commonly used drug for supplementing vitamin C, which can be used to prevent and treat scurvy, and assist in the treatment of various acute and chronic infectious diseases and purpura. However, the nature of vitamin C is extremely unstable, because the enol structure in vitamin C is easily oxidized, especially after contact with oxygen, light source, heat source, and other excipients in vitamin tablets, it will be automatically oxidized to generate dehydroascorbic acid, while dehydrogenation Ascorbic...

AI Technical Summary

Problems solved by technology

However, the nature of vitamin C is extremely unstable, because the enol structure in vitamin C is easily oxidized, especially after contact with oxygen, light source, heat source, and other excipients in vitamin tablets, it will be automatically oxidized to generate dehydroascorbic acid, while dehydrogenation Ascorbic acid will continue to hydrolyze, making vitamin C lose its therapeutic effect

[0003] Studies have shown that the process of wet granulation and tabletting will accelerate the process of vitamin C oxidation, making vitamin C tablets dark gray and shortening the shelf life. Therefore, wet granulation and tabletting should be abandoned in the production process of vitamin C tablets method, and in the tableting process, magnesium stearate is often added as a lubricant, but magnesium stearate will affect the stability of vitamin C

And to the improvement aspect of vitamin C tablet stability, the method that adopts at present mainly contains: (1) vitamin C is coated with coating material or β-cyclodextrin etc.; (2) preparation of derivatives of vitamin C, such as sodium vitamin C phosphate, the method has complicated synthesis process, harsh conditions, and higher production cost

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