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Whitening buccal tablets containing SOD components

A component and whitening technology, which is applied in the field of whitening lozenges with SOD components, can solve the problems of accelerating melanin metabolism and insufficient effect, and can reduce the formation of dopa and dopaquinone substances, with remarkable effect and speed up the skin. The effect of update speed

Inactive Publication Date: 2019-11-15
刘建辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The purpose of the present invention is to provide a buccal tablet that prevents melanin production, prevents melanin transfer, accelerates melanin metabolism, and resists oxidation in order to address the shortcomings of only one or two ways of whitening in the current market, and the effect is not outstanding enough.

Method used

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  • Whitening buccal tablets containing SOD components
  • Whitening buccal tablets containing SOD components

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] SOD 0.5%, Resveratrol 5%, Niacinamide 5%, Vitamin C 5%, Starch Slurry 12%, Magnesium Stearate 2%, Microcrystalline Cellulose 40%, Mannitol 30.5%. The dissolution of this embodiment is 15.30min.

[0043] Preparation includes the following steps:

[0044] Step 1: Weigh SOD, resveratrol, nicotinamide, vitamin C, microcrystalline cellulose, and mannitol, pass through a 100-mesh sieve, and mix well;

[0045] Step 2: granulating, adding starch slurry to make soft material, and granulating through a 20-mesh sieve;

[0046] Step 3: drying, the drying temperature is 30°C;

[0047] Step 4: granulation and tabletting. After granulation, in order to make the surface of the buccal tablet smooth and easier to release from the mold, add magnesium stearate, mix evenly, and send it to a tablet machine for tableting;

[0048] Step 4: Sterilization and packaging, irradiating the tablet under ultraviolet light for 15 minutes, and performing blister packaging.

Embodiment 2

[0050] Formula SOD 0.6%, Resveratrol 6%, Niacinamide 6%, Vitamin C 6%, Starch Slurry 11%, Talc 1.4%, Microcrystalline Cellulose 37%, Sorbitol 32%. The dissolving time of the present embodiment is 19.53min.

[0051] Preparation includes the following steps:

[0052] Step 1: Weigh SOD, resveratrol, nicotinamide, vitamin C, microcrystalline cellulose, and sorbitol, pass through a 100-mesh sieve, and mix well;

[0053] Step 2: granulating, adding starch slurry to make soft material, and granulating through a 20-mesh sieve;

[0054] Step 3: drying, the drying temperature is 30°C;

[0055] Step 4: Sizing and tableting. After sizing, in order to make the surface of the buccal tablet smooth and easier to release from the mold, add talcum powder, mix evenly, and send it to a tablet machine for tableting;

[0056] Step 4: Sterilization and packaging, irradiating the tablet under ultraviolet light for 15 minutes, and performing blister packaging.

Embodiment 3

[0058] Formula: SOD 0.7%, Resveratrol 7%, Nicotinamide 7%, Vitamin C 7%, Starch Slurry 10%, Polyethylene Glycol-4000 1%, Microcrystalline Cellulose 38%, Glucose 29.3%. The dissolving time of the present embodiment is 17.25min.

[0059] Preparation includes the following steps:

[0060] Step 1: Weigh SOD, resveratrol, nicotinamide, vitamin C, microcrystalline cellulose, and glucose through a 100-mesh sieve and mix well;

[0061] Step 2: granulating, adding starch slurry to make soft material, and granulating through a 20-mesh sieve;

[0062] Step 3: drying, the drying temperature is 30°C;

[0063] Step 4: Sizing and tableting. After sizing, in order to make the surface of the buccal tablet smooth and easier to release from the mold, add polyethylene glycol-4000, mix evenly, and send it to a tablet machine for tableting;

[0064] Step 4: Sterilization and packaging, irradiating the tablet under ultraviolet light for 15 minutes, and performing blister packaging.

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Abstract

The invention provides whitening buccal tablets containing SOD components. The whitening buccal tablets consist of the following raw materials in percentage by weight of 0.5-1% of SOD, 5-10% of resveratrol, 5-10% of nicotinamide, 5-10% of vitamin C, 10-12% of starch slurry, 1-2% of a lubricant, 30-40% of microcrystalline cellulose and 20-32% of a correctant. The SOD is added, so that free radicalscan be eliminated, and formation of melanin is reduced; the resveratrol is added, so that the activity of tyrosinase can be restrained, and the formation of the melanin can be reduced; the nicotinamide is added, so that transmission of melanin granules to horn cells can be restrained, and the skin renewal rate can be increased; the vitamin C is added, so that melanin intermediates and melanin polymers are reduced, skin and muscle are whitened in various ways, effects are notable, and the components are safe. The dissolving time is between 18.53-22.60min, so that the absorption time of the antioxidant passing through the oral mucosa can be guaranteed, and the situations that the time is too long and the whitening buccal tablets are inconvenient to use cannot be caused.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to a whitening buccal tablet added with SOD components. Background technique [0002] As the saying goes: "One white covers three ugliness", the current mainstream aesthetics still pursue fair skin. The change of skin color is a complex dynamic process, which is affected by many factors, such as the pigment in the skin, the thickness of epidermis and dermis, etc. There are many methods of whitening, such as: [0003] (1) prevent melanin synthesis [0004] Tyrosinase, dopachrome interconverting enzyme, and 5,6-dihydroxyindole-2-carboxylate oxidase are the most important biological enzymes in the process of melanin formation, and tyrosinase is the rate-limiting enzyme in this process , tyrosinase mainly catalyzes the hydroxylation of monohydric phenols to generate dihydroxy compounds and the oxidation of catechol to generate catechols. These two types of reactions in...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/20A23L33/17A23L33/10A23P10/28A61P17/18A61P37/04A61P39/06A61K31/05A61K31/375A61K31/455
CPCA23L33/10A23L33/17A23P10/28A23V2002/00A61K9/0056A61K9/2059A61K31/05A61K31/375A61K31/455A61K38/446A61P17/18A61P37/04A61P39/06C12Y115/01001A61K2300/00A23V2200/318A23V2200/324A23V2200/302A23V2250/708A23V2250/7046A23V2250/54
Inventor 谢佩明刘婧
Owner 刘建辉
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