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Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material as well as preparation method and application thereof

A composite material, carbon nanotube technology, applied in the preparation of cyanide reaction, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of difficult solid-liquid separation, limited application scope, etc. , the effect of small particle size

Active Publication Date: 2020-06-05
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on nanomaterials in the field of chiral recognition has gained more and more attention, but most nanomaterials are difficult to achieve solid-liquid separation in solution, which greatly limits their application range.

Method used

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  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material as well as preparation method and application thereof
  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material as well as preparation method and application thereof
  • Self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1—Preparation method of self-assembled hexadecyl-L hydroxyproline functionalized magnetic-carbon nanotube composite material

[0026] (1) Magnetic Fe 3 o 4 Preparation of / MWCNTs composites

[0027] Weigh 1.35g FeCl 3 ·6H 2 O was added to 35 mL of ethylene glycol solution. Then, 3.6 g of anhydrous sodium acetate, 1.0 g of polyethylene glycol and 0.2 g of carboxylated multi-walled carbon nanotubes were sequentially added, and ultrasonically dispersed for 0.5 h. Add 6 mL of hexamethylenediamine, continue mechanical stirring for 0.5 h, then transfer the liquid to a sealed stainless steel hydrothermal reaction kettle with a polytetrafluoroethylene liner, and heat to 220°C for 8 h. The obtained product was washed 6 times with deionized water and absolute ethanol, and dried under vacuum at 80 °C to prepare magnetic Fe 3 o 4 / MWCNTs composites.

[0028] (2) Preparation of self-assembled amino acid derivative functionalized magnetic-carbon nanotube composites

...

Embodiment 2

[0031] Embodiment 2—Structural characterization of magnetic materials

[0032] (1) Shape and size characterization

[0033] The particle size and morphology of the prepared magnetic particles were observed with a Tecnai G2F20 transmission electron microscope (FEI, USA). figure 1 is magnetic Fe 3 o 4 Nanoparticles and Magnetic Fe 3 o 4 / MWCNTs-Hyp composite transmission electron micrographs. From figure 1 (a) It can be seen that the magnetic Fe without multi-walled carbon nanotubes 3 o 4 Nanoparticles are petal-like, with a particle size of 80±5nm; figure 1 (b) shows magnetic Fe 3 o 4 Magnetic Fe in / MWCNTs-Hyp composites 3 o 4 The nanoparticles are evenly deposited on the carbon nanotubes, with a particle size of 60±5nm. After the carbon nanotubes are added, the steric hindrance increases, which leads to the restriction of the growth of the crystal nucleus, making the magnetic Fe 3 o 4 The particle size of the nanoparticles is reduced.

[0034] (2) Crystal form ...

Embodiment 3

[0040]Example 3—Self-assembled hexadecyl-L-hydroxyproline functionalized magnetic-carbon nanotube composite material for splitting amino acids

[0041] The self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material prepared by the technical scheme of the present invention is used to resolve amino acid chiral isomers. With magnetic Fe 3 o 4 / MWCNTs-Hyp composite material is used as a chiral adsorbent to resolve amino acid enantiomers in solution to test its chiral resolution ability, in which the functional group L-hydroxyproline is the chiral recognition agent Ligand. The chiral ligand coordinates with the D- and L-enantiomers of the amino acid respectively through the central metal ion to form a complex of two diastereoisomers, and the stability of the two complexes is different , thus achieving chiral separation.

[0042] DL-phenylalanine was selected as the analyte, and the resolution effect was analyzed by HPLC. Use acetonitrile-wa...

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Abstract

The invention discloses a self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material as well as a preparation method and application thereof. The magnetic Fe3O4-multiwalled carbon nanotube composite material is prepared by a solvothermal reduction one-step method. The preparation method comprises the following steps: self-assembling N-hexadecyl-L-hydroxyprolineon the surface of carbon nanotubes by utilizing the hydrophobic effect of a magnetic Fe3O4 / MWCNTs composite material to obtain a stable compound, and splitting an amino acid enantiomer by using the material as a chiral adsorbent so as to test the chiral splitting performance of the material. A chiral recognition material is prepared by taking the magnetic nano material as a chiral selector carrier and combining a self-assembly technology as a fixing mode, so that the defects of stability and loading capacity of a chiral stationary phase are expected to be overcome, and rapid screening of chiral selectors and efficient and high-capacity chiral separation are realized.

Description

technical field [0001] The invention belongs to the technical field of functional materials and chiral separation, and more specifically relates to a self-assembled amino acid derivative functionalized magnetic-carbon nanotube composite material and its preparation method and application in chiral separation. Background technique [0002] The two enantiomers of chiral compounds have the same physical and chemical properties except optical activity, but their biochemical and pharmacological activities are often different, or even have opposite effects. Therefore, the study of chiral separation technology is of great significance to the pharmaceutical industry and life science. Chiral resolution technology mainly includes mechanical resolution, preferential crystallization, chemical resolution, enzymatic resolution, membrane separation and chromatographic resolution and other resolution methods. Among them, the liquid chromatography chiral stationary phase resolution method i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/29B01J20/28B01J20/30C07C227/34C07C229/36G01N30/74
CPCB01J20/29B01J20/28009C07C227/34G01N30/74C07C229/36
Inventor 邓小娟李文斌
Owner TIANJIN UNIV
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