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Biodegradable nano-membrane for vascular surgery and preparation method thereof

A biodegradable, nanomembrane technology, applied in medical science, surgery, fiber processing, etc., can solve the problems of slow biodegradation, poor toughness of polylactic acid, effective regulation of mechanical strength and biodegradation speed, etc. The effect of improving toughness and strength, improving bonding fastness and bonding amount

Active Publication Date: 2020-11-10
中控国工(北京)医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Biodegradable polymer drug coatings based on polylactic acid have been widely used, but polylactic acid has poor toughness and slow biodegradation
For example, the invention patent CN109602953 discloses a new type of long-acting slow-release VEGF and bFGF degradable bio-nano-membrane and its preparation method. The method obtains degradable nano-fiber membrane by electrospinning degradable polymer materials such as polylactic acid , and then through electrostatic adsorption, the growth factors are loaded on the surface of the nanofiber membrane to obtain a biodegradable bionano membrane, which can be used for the treatment of vascular diseases, but this scheme does not effectively control the mechanical strength and biodegradation rate

Method used

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  • Biodegradable nano-membrane for vascular surgery and preparation method thereof

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preparation example Construction

[0044] A preparation method of the above-mentioned biodegradable nano-membrane for vascular surgery, comprising the following steps:

[0045] S1. Disperse the biodegradable polymer in a polar solvent, and then perform electrospinning to obtain a polymer nanofilm;

[0046] S2. With magnesium acetate and 2,5-dihydroxyterephthalic acid as raw materials, first the polymer nanofilm obtained in step S1 is soaked and adsorbed in a tetrahydrofuran solution of 2,5-dihydroxyterephthalic acid for 30- 60min, then impregnated and adsorbed in the mixed solution of magnesium acetate tetrahydrofuran and water for 30-60min, and finally impregnated the impregnated and adsorbed polymer nanomembrane in magnesium acetate and 2,5-dihydroxy p- In a mixed solution of tetrahydrofuran and water of phthalic acid, react at 110-130°C for 4-6 hours to obtain a coating-modified polymer nanofilm;

[0047] S3. Immerse the surface of the coating-modified polymer nanomembrane obtained in step S2 in the mixed a...

Embodiment 1

[0050] A biodegradable nano-membrane for vascular surgery, comprising the following components by mass percentage: 95% biodegradable polymer film, 4.89% metal-organic framework composed of magnesium and terephthalic acid, 0.055% epithelial-stimulating Growth factors, 0.055% pro-angiogenic growth factors.

[0051] The biodegradable polymer film is a polymer film formed by an ABCBA pentablock copolymer composed of polylactic acid, polycaprolactone and poly(1,8-octanediol-citric acid), wherein A represents polylactic acid Chain segment, B represents polycaprolactone segment, C represents poly(1,8-octanediol-citric acid) segment, in which polylactic acid, polycaprolactone and poly(1,8-octanediol-citric acid) acid) are respectively 40%, 40% and 20%, and the synthetic method is as follows:

[0052] a. Put 1,8-octanediol and citric acid at a molar ratio of 1:1.1 in a three-necked flask, and under nitrogen protection, heat and stir in an oil bath at 160°C until 1,8-octanediol and lem...

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Abstract

The invention provides a biodegradable nano-membrane for the vascular surgery department and a preparation method of the biodegradable nano-membrane. The biodegradable nano-membrane consists of a segmented copolymer membrane composed of polylactic acid, polycaprolactone and poly (1,8-octanediol-citric acid), a metal organic framework, an epithelial growth promoting factor and an angiogenesis promoting factor. The preparation method comprises the following steps: carrying out electrostatic spinning on a segmented copolymer to obtain a polymer membrane, and then carrying out in-situ synthesis onthe surface of the polymer membrane to obtain a metal organic framework coating; and finally, loading a growth factor on the surface of a composite nano-membrane through the chemical bonding effect of carboxyl on the surface of the polymer membrane and amino on the surface of the epithelial growth promoting factor and the surface of the angiogenesis promoting factor. The five-membered segmented copolymer synthesized by the method has good mechanical strength and toughness and a proper biodegradation speed, and the metal organic framework grows on the surface, so that the mechanical property and the specific surface area of the five-membered segmented copolymer membrane can be improved, and then the loading capacity of the growth factor is improved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a biodegradable nano-membrane for vascular surgery and a preparation method thereof. Background technique [0002] Vascular surgical diseases refer to all peripheral blood vessels except cerebrovascular and cardiovascular diseases, namely, arterial and venous diseases that occur in the limbs, chest and abdomen, and neck, such as thrombosis, blood vessel blockage, varicose veins, etc., which seriously threaten the health of residents. At present, interventional therapy, as a minimally invasive treatment with small trauma and good curative effect, has undoubtedly become the first choice for the treatment of most arterial diseases. Interventional therapy has experienced several technological revolutions such as balloon forming, bare metal stents, and drug-eluting stents, and has been widely used in the fields of cardiovascular, cerebrovascular, visceral blood vessels, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/16A61L31/14D06M15/37D01F6/84C08G63/60C08G63/78D06M101/32
CPCA61L31/06A61L31/14A61L31/148A61L31/16A61L2300/414C08G63/60C08G63/78C08G2230/00D01F6/84D06M15/37D06M2101/32C08L87/005
Inventor 刘成刚
Owner 中控国工(北京)医疗科技有限公司