1, 4-dihydropyridine polymer as well as high-throughput preparation method and application thereof

A compound, C1-C3 technology, which is applied in the field of 1,4-dihydropyridine functional polymers and their high-throughput preparation, can solve the problems of many by-products, harsh reaction conditions, low yield and the like, and achieves simple operation. , Improve antibacterial ability, good universal effect

Active Publication Date: 2020-07-24
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Hantzsch reaction has disadvantages such as low yield, many by-products, and harsh reaction conditions.

Method used

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  • 1, 4-dihydropyridine polymer as well as high-throughput preparation method and application thereof
  • 1, 4-dihydropyridine polymer as well as high-throughput preparation method and application thereof
  • 1, 4-dihydropyridine polymer as well as high-throughput preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prepare 1,4-dihydropyridine polymer from cinnamaldehyde, 5,5-dimethyl 1,3-cyclohexanedione, the steps are as follows:

[0057] 1) Add (397mg, 3mmol) cinnamaldehyde, (643mg, 3mmol) acetoacetate methacrylate (AEMA), (347mg, 4.5mmol) ammonium acetate and (421mg, 3mmol) to a 10mL polymerization tube, 5, 5-Dimethyl-1,3-cyclohexanedione, (of which cinnamaldehyde, ethylene glycol methacrylate acetoacetate, ammonium acetate, 5,5-dimethyl-1,3-cyclohexanedione Feeding molar ratio is 1:1:1.5:1) (15mg, 0.06mmol) azobisisoheptanonitrile (ABVN) and (30mg, 0.4mmol) glycine, 3mL of acetonitrile and 3mL of 1,4-dioxane ring as a solvent. After the solution was deoxygenated with nitrogen, it was placed in an oil bath at 75°C for reaction.

[0058] 2) Pour the mixture reacted in step 1) for 10 hours into deionized water to precipitate, centrifuge to collect the filter residue, dissolve the filter residue with 5mL THF, precipitate in ether, collect the yellow solid obtained by centrifugat...

Embodiment 2

[0062] Example 2. Preparation of 1,4-dihydropyridine polymers from citronellal and 1,3-cyclohexanedione, the steps are as follows:

[0063] 1) Add (463mg, 3mmol) citronellal, (643mg, 3mmol) acetoacetate methacrylate (AEMA), (347mg, 4.5mmol) ammonium acetate and (342mg, 3mmol) 1 ,3-cyclohexanedione, (wherein the molar ratio of cinnamaldehyde, acetoacetate methacrylate, ammonium acetate, 5,5-dimethyl-1,3-cyclohexanedione is 1:1 :1.5:1). (15 mg, 0.06 mmol) of azobisisoheptanonitrile (ABVN) and (30 mg, 0.4 mmol) of glycine, 3 mL of acetonitrile and 3 mL of 1,4-dioxane as solvents. After the solution was deoxygenated with nitrogen, it was placed in an oil bath at 75°C for reaction.

[0064] 2) Pour the mixed solution reacted for 10 hours in step 1) into deionized water to precipitate, collect the filter residue by centrifugation, dissolve the filter residue with 5mL tetrahydrofuran, and then precipitate in ether, collect the yellow solid obtained by centrifugation, and freeze-dry...

Embodiment 3、1

[0068] The antibacterial experiment of embodiment 3,1,4-dihydropyridine polymer antibacterial agent

[0069] 1. Blend 1.5 g of the 1,4-dihydropyridine polymer obtained in Example 1 with 3.0 g of polypropylene (PP) powder, and heat-press at 180° C. for 10 minutes to obtain a compressed tablet with a thickness of 0.45 mm.

[0070] 2. The above-mentioned compressed tablets were sterilized by irradiating with ultraviolet light for 30 minutes, and then put into a Erlenmeyer flask filled with 200 mL of sterile LB medium, and placed for use.

[0071] 3. Take 200 μL of seed solution (OD600=1.0) of Escherichia coli (E.coli) after RFP transfection, grow on a shaker (180 rpm, 37°C) for 72 hours, take it out and place it in paraformaldehyde (4%) for fixation, Confocal laser microscopy was used to observe the bacterial contamination, and the green light at 566 nanometers was used for excitation.

[0072] 4. According to the above steps, press 4.5 g of polypropylene into a tablet to obtain...

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Abstract

The invention discloses a 1, 4-dihydropyridine functional polymer and a preparation method thereof. The preparation method of the polymer comprises the following steps: (1) in an anhydrous organic solvent, uniformly mixing fatty aldehyde, ammonium acetate, acetoacetic acid ethylene glycol methacrylate, a 1, 3-diketone compound, a radical initiator and a catalyst to obtain a component A; and (2) removing oxygen in the component A system, carrying out a reaction to obtain a component B, and obtaining the 1, 4-dihydropyridine functional polymer from the component B through separation. Through analysis of antibacterial experiment results, the polymer has good antibacterial ability. The structure is shown as a formula I in the specification.

Description

technical field [0001] The invention relates to a 1,4-dihydropyridine functional polymer and a high-throughput preparation method and application thereof, belonging to the field of chemical synthesis. Background technique [0002] 1,4-Dihydropyridine compounds are an important class of drugs with special pharmacological activities and can be used as calcium antagonists, which are a common class of calcium antagonist antihypertensive drugs. Such compounds can also be used as growth-promoting additives, etc., and their own fluorescence properties have also attracted much attention. Therefore, the synthesis of such compounds has aroused great interest and enthusiasm in recent years. The traditional synthesis of 1,4-dihydropyridines is mainly through the Hantzsch reaction, using ethyl acetoacetate, aldehydes and ammonia to condense to generate 1,4-dihydropyridines. The traditional Hantzsch reaction has disadvantages such as low yield, many by-products, and harsh reaction condi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F120/36C08L23/12C08L33/14
CPCC08F120/36C08L23/12C08L33/14
Inventor 陶磊刘国强
Owner TSINGHUA UNIV
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