Method for controlling degradation rate of medical magnesium-based material composite biological coating

A biological coating and degradation rate technology, applied in coatings, neural learning methods, biological neural network models, etc., can solve problems such as unpredictable degradation rates, achieve good intelligent characteristics, simplify prediction and control processes, and realize analysis and predicted effect

Inactive Publication Date: 2020-08-28
ZHEJIANG UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surface modification can improve the corrosion resistance of medical magnesium-based implant materials, but its degradation rate is unpredictable

Method used

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  • Method for controlling degradation rate of medical magnesium-based material composite biological coating
  • Method for controlling degradation rate of medical magnesium-based material composite biological coating
  • Method for controlling degradation rate of medical magnesium-based material composite biological coating

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Experimental program
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preparation example Construction

[0055] (1.1) Preparation of LSP coating: adopt the parameter values ​​of laser energy, shot-peening temperature, laser shot-peening number of times determined in step 6, adopt laser to carry out laser shock on the surface of magnesium-based material, prepare LSP on the surface of magnesium-based material coating samples;

[0056] (1.2) Preparation of LSP / MAO composite biological coating: take the LSP coating sample prepared in step (1.1) as the basic sample; select sodium silicate, sodium fluoride, potassium hexafluorotitanate, hydroxyapatite and ethylene glycol are electrolyte components, where Na 2 SiO 3 9H 2 O: 12g / L, NaF: 5g / L, K 2 TiF 6 : 2g / L, HA nanoparticles (20nm): 3g / L, ethylene glycol: 10ml / L; adjust the pH value of the electrolyte to 12 with NaOH; adopt the current density, treatment time and electrolyte concentration determined in step 6 Parameter value, prepare LSP / MAO composite biological coating on the surface of LSP coating sample;

[0057] (1.3) The out...

specific Embodiment

[0062] A hot-rolled AZ80 magnesium alloy plate of 60mm×20mm×2mm was selected as the substrate for surface modification treatment, and the substrate was polished with abrasive paper to ensure a certain surface toughness. Subsequently, the samples were ultrasonically degreased in ethanol for 10 min, washed with distilled water, and dried naturally in air.

[0063] Use the above-mentioned pretreated magnesium alloy substrate to prepare the LSP coating, and use the YAG laser to modify the surface of the substrate with LSP. The process parameters of the YAG laser are set as follows: laser energy A is 2J, and shot peening temperature B is 120°C , the number C of laser peening is 3 times, the wavelength is 1064nm, the pulse width is 20ns, the spot diameter is 3mm, and the overlap rate is 50%. Use water with a thickness of about 1mm as a transparent cover, and use professional aluminum foil with a thickness of 0.1mm as an absorbent cover to protect the substrate surface from thermal e...

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Abstract

The invention provides a method for controlling the degradation rate of a medical magnesium-based material composite biological coating. The method comprises the following steps of: changing six process parameters influencing the degradation rate to prepare medical magnesium-based material composite biological coatings with different degradation rates, wherein the six process parameters are laserenergy, shot blasting temperature, laser shot blasting times, current density, treatment time and electrolyte concentration; and performing network training by using a BP neural network optimized by agenetic algorithm by taking the six process parameters as an input layer and the degradation rate as an output layer to obtain a BP neural network prediction model with a relatively small error. Themethod has good intelligent characteristics, the prediction and control process of the degradation rate is greatly simplified, and manpower, material resources and financial resources are saved. The corrosion resistance and mechanical property of a medical magnesium alloy implant material are effectively improved, and possibility is provided for wide application of the medical magnesium alloy implant material.

Description

technical field [0001] The invention relates to the technical field of medical magnesium-based material composite biological coatings, in particular to a method for controlling the degradation rate of medical magnesium-based material composite biological coatings. Background technique [0002] Magnesium, as an important element necessary to participate in the synthesis and metabolism of human body substances, has good biocompatibility and mechanical properties, and has a density and mechanical properties close to that of human bone, so it attracted the attention of medical workers as early as the beginning of the 20th century. . Its unique in vivo degradation characteristics can effectively avoid secondary surgery caused by traditional implant materials, so it is regarded as the most promising medical implant material. However, the corrosion resistance of medical bio-magnesium alloys is poor. Clinical studies have found that the excessive corrosion rate in the body will cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22F3/00C25D11/30G06N3/04G06N3/08G06N3/12
CPCC22F3/00C25D11/026C25D11/30G06N3/084G06N3/126G06N3/044
Inventor 熊缨朱涛杨杰沈永水何留永
Owner ZHEJIANG UNIV OF TECH
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