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Self-adhesive hydrogel patch with self-generating performance as well as preparation method and application of self-adhesive hydrogel patch

A hydrogel paste, self-adhesive technology, applied in the direction of application, electrotherapy, conductive adhesive, etc., can solve the problems of accelerating skin wound healing, inconvenient use, bulky electrotherapy equipment, etc., to achieve pain relief and economical Effects of burden, cheapness, inconvenient use, and shortened repair time

Active Publication Date: 2020-10-09
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention solves the technical problem that the self-adhesive hydrogel cannot accelerate the healing of skin wounds in the prior art, and the problem that the electrotherapy equipment is bulky and inconvenient to use, and provides a high-adhesion hydrogel with self-generating properties Patches and their use in promoting skin wound healing

Method used

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  • Self-adhesive hydrogel patch with self-generating performance as well as preparation method and application of self-adhesive hydrogel patch
  • Self-adhesive hydrogel patch with self-generating performance as well as preparation method and application of self-adhesive hydrogel patch
  • Self-adhesive hydrogel patch with self-generating performance as well as preparation method and application of self-adhesive hydrogel patch

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A method for preparing a highly adhesive hydrogel patch with spontaneous piezoelectric properties, comprising the following steps:

[0041] A, preferably, mix dopamine (1%Wt, according to the total mass of the hydrogel, the same below), tannic acid (0.5%Wt.) into water (80%Wt.) with pH=10, and stir evenly Configured as a solution, add polyvinyl alcohol (as thickener, molecular weight 1000, 8%Wt.), acrylamide (monomer of hydrogel, 8%Wt.), ammonium persulfate (as initiator, 2%Wt. .), tetramethylethylenediamine (as a catalyst, 0.5% Wt.), cross-linked into a self-adhesive hydrogel at room temperature, and purified by distilled water immersion to remove harmful substances such as unreacted monomers.

[0042] B. Preferably, polyvinylidene fluoride (PVDF) and nano-ZnO particles with a molecular weight of 530000Da are prepared into an electrospinning solution with a mass fraction of 18% (PVDF:ZnO is 95:5, mass ratio), and the solvent is N, N- dimethylformamide. The voltage of...

Embodiment 2

[0045] A method for preparing a highly adhesive hydrogel patch with spontaneous triboelectric properties, comprising the following steps:

[0046] A, preferably, mix dopamine (0.5%Wt, according to the total mass of the hydrogel, the same below), tannic acid (2%Wt.) and add in water (70%Wt.) with pH=10, stir well Configured into a solution, adding sodium alginate (25% Wt.) and anhydrous calcium chloride (2.5% Wt.), cross-linked into a self-adhesive hydrogel at 60 ° C, and purified by distilled water immersion to remove unreacted mono body and other harmful substances;

[0047] B. Preferably, a polyvinylidene fluoride-trifluoroethylene copolymer (PVDF-TrFE) with a molecular weight of 430,000 Da is added to the solvent dimethyl sulfoxide to prepare an electrospinning solution with a mass fraction of 25%. The voltage of electrospinning is 20kV, the flow rate is 0.8mL / h, and the receiver is a high-speed rotating hub with a rotating speed of 2800r / min. A polymer film composed of pa...

Embodiment 3

[0051] A method for preparing a highly adhesive hydrogel patch with spontaneous pyroelectric discharge performance, comprising the following steps:

[0052] A, preferably, dopamine (0.5%Wt, by hydrogel total mass, the same below) is added in the water (80%Wt.) of pH=11, stirs and is configured into a solution, adds carboxymethyl cellulose ( 1%Wt.), polyethylene glycol diacrylate (15%Wt.), N,N-methylenebisacrylamide (0.5%), photoinitiator ketoglutaric acid (3%Wt.), stirring Uniform, cross-linked into a self-adhesive hydrogel under ultraviolet light, and purified by immersion in distilled water to remove unreacted monomers and other harmful substances.

[0053] B. Preferably, polyvinyl fluoride (PVF2) with a molecular weight of 320,000 Da is added to the solvent dimethylacetamide to prepare a solution with a mass fraction of 20%. Afterwards, slowly add 4% Wt. nano-lithium tantalate particles to it, stir evenly, cast on aluminum foil, heat-melt at 210°C, and quench with ice-wate...

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Abstract

The invention discloses a self-adhesive hydrogel patch with self-generating performance as well as a preparation method and an application thereof, and belongs to the field of hydrogel biomedical materials. The patch is prepared by compounding self-adhesive hydrogel and a nano power generation device. The nano power generation device comprises a power generation layer with a piezoelectric effect,a triboelectric effect or a pyroelectric effect and an electrode. The patch disclosed by the invention can be automatically adhered to the skin, does not need a fixing adhesive tape, isolates a woundfrom being in contact with external bacteria, avoids infection, is breathable and moisturized, and is beneficial to maintaining a wound healing environment. When a treated object moves or even breathes, the high-adhesive hydrogel patch with the self-power-generation performance can convert mechanical energy and heat energy into electric energy, an external electric field is generated to influencethe transcutaneous potential of a wound, cell proliferation, migration and epidermal regeneration are promoted, and wound repair is accelerated.

Description

technical field [0001] The invention belongs to the field of hydrogel biomedical materials, more specifically, relates to a self-adhesive hydrogel patch with self-generating performance and its preparation method and application, especially to a high-adhesive hydrogel patch with self-generating performance. The hydrogel patch, its preparation method and its application in the preparation of patch materials for promoting skin wound healing. Background technique [0002] As the largest organ of the human body, the skin plays a vital barrier role in isolating harmful substances or bacteria from the outside world. After skin damage, the human body will start the process of skin self-repair. However, when a patient has a large area of ​​skin trauma, burns, or ulcers that are difficult to heal caused by chronic diseases such as diabetes, the skin will heal very slowly. If it cannot be treated in time and effectively, the wound will enter the chronic phase, which will cause Incre...

Claims

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Application Information

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IPC IPC(8): A61K50/00A61P17/02A61N1/04
CPCA61K9/0009A61N1/0468A61P17/02C09J9/02
Inventor 朱锦涛杜硕张连斌周诺娅陶娟
Owner HUAZHONG UNIV OF SCI & TECH
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