Self-adhesive hydrogel patch with self-generating properties and its preparation method and application
A hydrogel patch and self-adhesive technology, applied in the field of high-adhesion hydrogel patch and its preparation, and preparation of patch materials for promoting skin wound healing, which can solve the inconvenience of use, accelerate skin wound healing, and electrotherapy equipment Large size and other problems, to achieve the effect of promoting cell proliferation, reducing pain and economic burden, and shortening the repair time
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Embodiment 1
[0040] A method for preparing a highly adhesive hydrogel patch with spontaneous piezoelectric properties, comprising the following steps:
[0041] A, preferably, mix dopamine (1%Wt, according to the total mass of the hydrogel, the same below), tannic acid (0.5%Wt.) into water (80%Wt.) with pH=10, and stir evenly Configured as a solution, add polyvinyl alcohol (as thickener, molecular weight 1000, 8%Wt.), acrylamide (monomer of hydrogel, 8%Wt.), ammonium persulfate (as initiator, 2%Wt. .), tetramethylethylenediamine (as a catalyst, 0.5% Wt.), cross-linked into a self-adhesive hydrogel at room temperature, and purified by distilled water immersion to remove harmful substances such as unreacted monomers.
[0042] B. Preferably, polyvinylidene fluoride (PVDF) and nano-ZnO particles with a molecular weight of 530000Da are prepared into an electrospinning solution with a mass fraction of 18% (PVDF:ZnO is 95:5, mass ratio), and the solvent is N, N- dimethylformamide. The voltage of...
Embodiment 2
[0045] A method for preparing a highly adhesive hydrogel patch with spontaneous triboelectric properties, comprising the following steps:
[0046] A, preferably, mix dopamine (0.5%Wt, according to the total mass of the hydrogel, the same below), tannic acid (2%Wt.) and add in water (70%Wt.) with pH=10, stir well Configured into a solution, adding sodium alginate (25% Wt.) and anhydrous calcium chloride (2.5% Wt.), cross-linked into a self-adhesive hydrogel at 60 ° C, and purified by distilled water immersion to remove unreacted mono body and other harmful substances;
[0047] B. Preferably, a polyvinylidene fluoride-trifluoroethylene copolymer (PVDF-TrFE) with a molecular weight of 430,000 Da is added to the solvent dimethyl sulfoxide to prepare an electrospinning solution with a mass fraction of 25%. The voltage of electrospinning is 20kV, the flow rate is 0.8mL / h, and the receiver is a high-speed rotating hub with a rotating speed of 2800r / min. A polymer film composed of pa...
Embodiment 3
[0051] A method for preparing a highly adhesive hydrogel patch with spontaneous pyroelectric discharge performance, comprising the following steps:
[0052] A, preferably, dopamine (0.5%Wt, by hydrogel total mass, the same below) is added in the water (80%Wt.) of pH=11, stirs and is configured into a solution, adds carboxymethyl cellulose ( 1%Wt.), polyethylene glycol diacrylate (15%Wt.), N,N-methylenebisacrylamide (0.5%), photoinitiator ketoglutaric acid (3%Wt.), stirring Uniform, cross-linked into a self-adhesive hydrogel under ultraviolet light, and purified by immersion in distilled water to remove unreacted monomers and other harmful substances.
[0053] B. Preferably, polyvinyl fluoride (PVF2) with a molecular weight of 320,000 Da is added to the solvent dimethylacetamide to prepare a solution with a mass fraction of 20%. Afterwards, slowly add 4% Wt. nano-lithium tantalate particles to it, stir evenly, cast on aluminum foil, heat-melt at 210°C, and quench with ice-wate...
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