Application of citric acid metal salts in root canal therapy and preparation thereof

A metal salt, citric acid technology, applied in dental preparations, pharmaceutical formulations, compression mold cups, etc., can solve the problems of adverse reactions of sodium hypochlorite, difficult to remove non-organic components, EDTA stimulation, etc., to achieve safe and reliable use and save treatment time. , the effect of simplifying the operation steps

Active Publication Date: 2020-12-04
KUNMING LANCHIE DENTAL HOSPITAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, EDTA has certain irritation and allergy problems. At the same time, sodium hypochlorite will also cause some adverse reactions during root canal treatment, which is likely to cause very serious complications. The main disadvantages include: unacceptable smell and taste, use Discoloration of clothing, non-organic components of the smudge layer are difficult to remove, and it is difficult to penetrate deep into various positions of the root canal system
The invention claims that the lubricant has the effect of removing the root canal smear layer and good antibacterial effect. In this formula, the content of citric acid reaches 5-14%, and the acidity of the lubricant is relatively strong, that is, the acidity of the organic acid is used to remove Helps remove the smear layer, which obviously causes severe demineralization of the tooth tissue and is therefore not optimal
[0006] Chinese patent CN1633261A discloses a rinsing solution and its application method, including rinsing the tooth surface with a sterile solution containing disinfectants, detergents and organic acids to remove the stain layer. Obviously, this patented technology also utilizes the acidity of organic acids To remove the smear layer, there is also the problem of serious demineralization of the tooth tissue
[0007] Chinese patent CN101012511B discloses the method of utilizing sodium tripolyphosphate to eliminate the influence of calcium ions in gold heap leaching production, and discloses the use of sodium tripolyphosphate to chelate Ca2+ ions, but in the present invention, it has been proved by many tests that the tripolyphosphate Sodium phosphate is not effective in removing smear layer

Method used

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  • Application of citric acid metal salts in root canal therapy and preparation thereof
  • Application of citric acid metal salts in root canal therapy and preparation thereof
  • Application of citric acid metal salts in root canal therapy and preparation thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0062] 1.4. Preparation of SEM samples

[0063] After root canal preparation, use a low-speed cutting machine with water cooling to horizontally cut off the crown, 1 / 3 of the root crown, and 1 / 3 of the apex, and keep 1 / 3 of the root (about 5mm). Prepare a groove on each buccolingual side, about 2 mm deep but not through the root canal wall, and then use an osteotome to cut the root longitudinally into two along the long axis of the root. Each root canal is divided into two parts, and a total of two specimens are obtained from each tooth .

[0064] 1.5. Experimental processing

[0065] Select successively the commercially available "root canal lubricating fluid" containing 17-22% EDTA-2Na, physiological saline, test samples (formula 1-15 in Example 3), and selectively treat for 1 minute respectively according to the test design, or / and 5 minutes, or / and 10 minutes, then washed 3 times with distilled water, 1 minute each time, washed 2 times with PBS solution, dried naturally ...

Embodiment 1

[0127] The product is in liquid state, and is prepared by weight percentage with the following raw materials: 0.1% of dodecyl dimethyl benzyl ammonium chloride, 20.0% of sodium citrate, 1.0% of acetic acid, and deionized water as the balance.

[0128] Preparation; ①. Take the above-mentioned raw materials according to the mass ratio, mix them uniformly, and prepare a homogeneous solution at room temperature;

[0129] ②. Use a filling machine to pack into suitable containers to obtain finished products.

Embodiment 2

[0131] The product is a colloid, prepared by weight percentage with the following raw materials: dodecyl dimethyl benzyl ammonium chloride is 0.1%, sodium citrate is 20.0%, acetic acid is 1.0%, thickener hydroxypropyl methylcellulose 3.0%, with deionized water as the balance.

[0132] Preparation: ①. Take the above raw materials according to the mass ratio, and mix them;

[0133] ②. Dissolve hydroxypropyl methylcellulose in hot water above 70 degrees Celsius, fully disperse and swell, and cool to obtain colloid A;

[0134] ③. Prepare the remaining raw materials into a homogeneous solution at room temperature, and add it to colloid A;

[0135] ④. Use a filling machine to pack into suitable containers to obtain finished products.

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Abstract

The invention discloses application of citric acid metal salts in root canal therapy and a preparation thereof. The citric acid metal salts are used for removing a smeared layer, and consist of lithium citrate, sodium citrate, potassium citrate or magnesium citrate. A smeared layer can be effectively removed through specific citric acid metal salts so that a treatment mode of using an EDTA-containing preparation in current root canal therapy can be replaced; and moreover, defects of adopting inorganic acids or organic acids are also avoided. The invention further discloses a preparation prepared from the citric acid metal salts along with a single-chain cationic antibacterial agent compatible with the citric acid metal salts. Therefore, the problem of the current root canal therapy that effect can only be achieved by alternately using the EDTA-containing preparation and sodium hypochlorite is solved, thereby having operation procedures of dentists simplified; and moreover, the functions of the two necessary preparations in the current root canal therapy are combined into a whole so that adverse reactions caused by using the EDTA and the sodium hypochlorite are avoided. Thus, a better choice is provided for clinical root canal therapy.

Description

technical field [0001] The invention relates to the technical field of root canal treatment, in particular to the application of citrate metal salt in root canal treatment and the prepared preparation. Background technique [0002] The smear layer is the heat generated when cutting tooth tissue to denature the organic matter, and the denatured organic matter and the cut dentin powder are mixed with the dentinal tubule overflow fluid, saliva and bacteria, etc. attached to the cave wall. The content of organic matter in dentin is higher than that of enamel, so the smear layer formed by cutting dentin is thicker than enamel, and the smear layer can enter the dentinal tubules to form tube plugs, which cannot be removed by general washing methods. The existence of the smear layer will hinder the adhesion between the restoration and the cave wall. At the same time, because the surface free energy of the smear layer is low and it is hydrophilic, it is not conducive to the wetting ...

Claims

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Application Information

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IPC IPC(8): A61K6/00
CPCA61K6/00A61K6/52A61K6/69
Inventor 张磊孙宇陆可望龙洋方苑
Owner KUNMING LANCHIE DENTAL HOSPITAL CO LTD
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