Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof

A technology of bovine serum albumin and nanocomposite materials, which is applied in the direction of nanotechnology, nanotechnology, nano-optics, etc. for materials and surface science, can solve the limitation of penetration depth, the influence of MR imaging artifacts on accuracy, and the difficulty Treatment and other problems, to achieve the effect of simple preparation method, integration of diagnosis and treatment, and low price

Active Publication Date: 2020-12-11
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the prepared composite material is a good T1-MRI contrast agent, which can be used for tumor screening and guided photodynamic therapy, but this invention is only applicable to photodynamic therapy (PDT), and the penetration depth is limited. Larger t...

Method used

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  • Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof
  • Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof
  • Bovine serum albumin modified protoporphyrin/trimanganese tetroxide /carbon oxynitride nano composite material as well as preparation and application thereof

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Effect test

Embodiment 1

[0054] A preparation method of bovine serum albumin-modified protoporphyrin / manganese tetroxide / carbon nitride oxide nanocomposite material, comprising the following steps:

[0055] (1) Prepare a uniformly dispersed carbon oxide nitride nanosheet aqueous solution, and the specific steps are as follows:

[0056] (11) 10g of melamine was heated to 550°C at 3°C / min in a muffle furnace, kept for 3h, and cooled to room temperature naturally to obtain graphite phase carbon nitride, which was ground into powder for subsequent use;

[0057] (12) dissolve 1 g of the graphitic carbon nitride obtained in step (11) into 50 mL of concentrated sulfuric acid, slowly add 3.5 g of potassium permanganate under ice bath, and keep stirring; after the potassium permanganate is completely dissolved, transfer In a water bath at 37°C, continue to stir and react for 4 hours; slowly add 200 mL of deionized water to dilute in an ice bath, and finally add 30% hydrogen peroxide solution dropwise until the...

Embodiment 2

[0079] A preparation method of bovine serum albumin-modified protoporphyrin / manganese tetroxide / carbon nitride oxide nanocomposite material, comprising the following steps:

[0080](1) Prepare a uniformly dispersed carbon oxide nitride nanosheet aqueous solution, and the specific steps are as follows:

[0081] (11) heating the melamine to 500°C at 3°C / min in a muffle furnace, maintaining for 4h, and naturally cooling to room temperature to obtain graphitic carbon nitride, which is ground into powder for subsequent use;

[0082] (12) the graphitic carbon nitride obtained in step (11) is dissolved in the concentrated sulfuric acid, and potassium permanganate is slowly added under an ice bath, wherein the moles of graphitic carbon nitride, concentrated sulfuric acid and potassium permanganate are The ratio is 1:80:1.8, stirring constantly; after the potassium permanganate is completely dissolved, transfer to a water bath at 36°C, continue stirring, and react for 4 hours; slowly a...

Embodiment 3

[0094] A preparation method of bovine serum albumin-modified protoporphyrin / manganese tetroxide / carbon nitride oxide nanocomposite material, comprising the following steps:

[0095] (1) Prepare a uniformly dispersed carbon oxide nitride nanosheet aqueous solution, and the specific steps are as follows:

[0096] (11) heating the melamine to 525°C at 3°C / min in a muffle furnace, maintaining for 3.5h, and naturally cooling to room temperature to obtain graphitic carbon nitride, which is ground into powder for subsequent use;

[0097] (12) the graphitic carbon nitride obtained in step (11) is dissolved in the vitriol oil, slowly adding potassium permanganate under ice bath, the molar ratio of graphitic carbon nitride, vitriol oil and potassium permanganate is 1:100:2.2, stirring continuously; after the potassium permanganate is completely dissolved, transfer to a water bath at 39 °C, continue stirring, and react for 4 hours; slowly add 200 mL of deionized water to dilute in an ice...

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Abstract

The invention relates to a bovine serum albumin modified protoporphyrin/trimanganese tetroxide/carbon oxynitride nano composite material as well as preparation and application thereof. The preparationmethod comprises the following steps: (1) preparing a uniformly dispersed carbon oxynitride nanosheet aqueous solution; (2) sequentially adding manganese acetate tetrahydrate and triethylamine into the carbon oxynitride nanosheet aqueous solution obtained in the step (1), performing continuous stirring, and preparing a trimanganese tetroxide-loaded carbon oxynitride nanomaterial through an in-situ growth method; and (3) loading protoporphyrin to the surface of the trimanganese tetroxide-loaded carbon oxynitride nanomaterial obtained in the step (2) by stirring, and adding bovine serum albuminfor modification. The material prepared by the method disclosed by the invention can be applied to magnetic resonance imaging and tumor sonodynamic therapy. Compared with the prior art, the bovine serum albumin modified protoporphyrin/trimanganese tetroxide/carbon oxynitride nano composite material disclosed by the invention has good biocompatibility and can be used as a magnetic resonance imaging contrast agent to guide sonodynamic therapy of tumors.

Description

technical field [0001] The invention relates to the technical fields of material science and biomedicine, in particular to a bovine serum albumin-modified protoporphyrin / manganese tetroxide / carbon oxide nitride nanocomposite material and its preparation and application. Background technique [0002] Accurate diagnosis and timely treatment of cancer are of great clinical significance. Therefore, many studies are devoted to developing intelligent nanomaterials to cope with the tumor microenvironment (low pH, hypoxia). In the past few decades, inorganic bases (such as Au, Fe 3 O 4 ) and organic-based (eg, human serum albumin, liposome) nanomaterials are often used as nanocarriers to load therapeutic agents in biomedical applications. However, the long-term toxicity of inorganic-based nanomaterials and the inability of organic-based nanomaterials to be used for imaging limit their accurate and safe diagnosis and treatment of tumors. Therefore, the development of multifunctio...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/64A61K49/14A61K49/18A61P35/00B82Y5/00B82Y20/00B82Y30/00B82Y40/00
CPCA61K47/643A61K41/0071B82Y5/00B82Y30/00B82Y40/00B82Y20/00A61K49/143A61K49/1824A61P35/00
Inventor 吴惠霞刘冶坪田娅杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
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