Lidocaine hydrochloride gel and preparation method thereof

A technology of lidocaine hydrochloride and gel, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve large drug loading, avoid vascular bleeding, and avoid irreversible damage Effect

Active Publication Date: 2021-01-26
北京中泰邦医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a lidocaine hydrochloride gel and its preparation method, to solve how to use volatile oil transdermal absorption enhancer, increase the transdermal absorption rate, play the functions of sterilization and anti-inflammation at the same time, reduce adverse reactions technical problems; how to increase the elasticity and permeability of blood vessels to avoid adverse reactions such as blood vessel bleeding caused by long-term use of traditional lidocaine drugs; and how to prepare the aerosol

Method used

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  • Lidocaine hydrochloride gel and preparation method thereof
  • Lidocaine hydrochloride gel and preparation method thereof

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Embodiment 1

[0042] This embodiment relates to a lidocaine hydrochloride gel and a preparation method thereof, which consists of the following components in parts by weight: 0.2 parts of lidocaine hydrochloride, 0.2 parts of xanthan gum as a gel matrix, hypromellose 0.2 part of E4M, 0.01 part of 0.1M sodium hydroxide, 8 parts of water for injection, 0.1 part of vitamin P, 0.2 part of eucalyptus oil, 0.5 part of Span 65, 1 part of Tween 80, 0.4 part of polyethylene glycol 400 ;

[0043] A preparation method for lidocaine hydrochloride gel, comprising the following steps:

[0044] a, extract eucalyptus oil;

[0045] B, the eucalyptus oil that step a extracts is mixed with Span 65, Tween 80, polyethylene glycol 400;

[0046] c. Dissolve an appropriate amount of vitamin P in water for injection to obtain a vitamin P aqueous solution; then weigh an appropriate amount of gel matrix and add vitamin P aqueous solution to dissolve, and finally add 0.1M sodium hydroxide to adjust the pH value to 6...

Embodiment 2

[0050] This embodiment relates to a lidocaine hydrochloride gel and a preparation method thereof, which consists of the following components in parts by weight: 3.7 parts of lidocaine hydrochloride, 3 parts of xanthan gum, 2 parts of tragacanth gum, carboxymethyl 2 parts of sodium cellulose base, 3 parts of 0.1M sodium hydroxide, 100 parts of water for injection, 1.8 parts of vitamin P, 2.5 parts of acacia flower oil, 2.5 parts of eucalyptus oil, 3 parts of Span 65 and 2 parts of Tween 80 , 3.5 parts polyethylene glycol 400.

[0051] A preparation method for lidocaine hydrochloride gel, comprising the following steps:

[0052] a, extracting acacia flower oil and eucalyptus oil;

[0053] B, acacia flower oil and eucalyptus oil that a step is extracted and Span 65 and Tween 80, Polyethylene Glycol 400 mix homogeneously;

[0054] c. Dissolve an appropriate amount of vitamin P in water for injection to obtain a vitamin P aqueous solution; then weigh an appropriate amount of gel ...

Embodiment 3

[0058] This embodiment relates to a lidocaine hydrochloride gel and a preparation method thereof, which consists of the following components in parts by weight: 2 parts of lidocaine hydrochloride, 1 part of xanthan gum, 1 part of methyl cellulose, carboxylate 1 part of sodium methylcellulose, 1.65 parts of 0.1M sodium hydroxide, 70 parts of water for injection; 1.2 parts of vitamin P; 1 part of eucalyptus oil, 1 part of acacia flower oil, 1.2 parts of Span 65 and 1.5 parts of Tween 80. 2 copies of Xitu Mage.

[0059] A preparation method for lidocaine hydrochloride gel, comprising the following steps:

[0060] a, extract eucalyptus oil, acacia flower oil;

[0061] B, the eucalyptus oil that a step extracts, acacia oil are mixed with Span 65, part of Tween 80, and Situma Ge;

[0062] c. Dissolve an appropriate amount of vitamin P in water for injection to obtain a vitamin P aqueous solution; then weigh an appropriate amount of gel matrix and add vitamin P aqueous solution to ...

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Abstract

The invention discloses lidocaine hydrochloride gel and a preparation method thereof. The lidocaine hydrochloride gel comprises the following components in parts by weight of 0.2-3.7 parts of lidocaine hydrochloride, 0.4-7 parts of a gel matrix, 0.01-3 parts of 0.1 M sodium hydroxide, 8-100 parts of water for injection, 0.1 to 1.8 parts of vitamin P; 0.2-5 parts of a volatile oil transdermal absorption enhancer, 0.2-5 parts of a surfactant and 0.4-3.5 parts of a cosurfactant. Vitamin P is added, the elasticity and permeability of capillary vessels are improved by improving the functions of thecapillary vessels, and adverse reactions such as vascular bleeding and the like caused by long-term use of traditional lidocaine drugs are avoided. By using the volatile oil transdermal absorption enhancer, the transdermal absorption rate is increased, the functions of sterilization, inflammation resistance and the like can be achieved, and the possibility of adverse reactions of medicines is reduced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a lidocaine hydrochloride gel and a preparation method thereof. Background technique [0002] Lidocaine or its pharmaceutically acceptable salts is an amide local anesthetic that stabilizes neuronal membranes by inhibiting the ionic flux generated by impulse initiation and conduction. Following transdermal administration, lidocaine or its pharmaceutically acceptable salts penetrate into intact skin in an amount sufficient to produce analgesia but not sufficient to produce a complete nerve block. [0003] The gel is a transdermal preparation, and the transdermal accelerators used mainly include azone, propylene glycol, urea, and menthol. However, the above-mentioned transdermal enhancer has a low skin penetration rate to the drug lidocaine hydrochloride, and may also increase drug transportation and storage costs. For example, menthol is easy to sublimate, and high temp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/167A61K36/61A61K47/10A61K47/26A61K47/36A61K47/38A61K47/44A61P17/02A61P23/02A61P29/00A61P31/02A61P31/12A61K31/7048
CPCA61K31/167A61K9/06A61K9/0014A61K47/36A61K47/38A61K47/44A61K47/26A61K47/10A61P23/02A61P29/00A61P31/02A61P17/02A61P31/12A61K31/7048A61K36/61A61K36/48A61K2300/00
Inventor 鲍亚华
Owner 北京中泰邦医药科技有限公司
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