A kind of preparation method of α,α-difluoro-β-ketosulfone compound

Abstract

The invention provides a method for preparing α,α-difluoro-β-ketone sulfone compounds, which belongs to the field of chemical technology. At first a kind of composition of compound shown in the preparation formula I is provided, and it is made up of following components: compound 1, fluoride initiator and organic solvent; Wherein, Ar 1 and Ar 2 are independently selected from substituted or unsubstituted aryl groups, substituted or unsubstituted heteroatom aryl groups. Also provided is a method for preparing α,α-difluoro-β-ketone sulfone compounds from the composition. The invention uses metal fluorides as initiators, and can prepare a series of compounds under mild conditions. The preparation method has a simple synthetic route, good yield and high purity; it has the advantages of excellent functional group adaptability, etc., and can be used to prepare α,α-difluoro-β-ketone sulfone compounds with various functional groups, and has been successfully applied to Post-modification of natural product and drug molecules. In addition, the reaction scale of the present invention can be enlarged to gram level, can be used for industrial scale-up production, and has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of chemistry, and in particular relates to a preparation method of α,α-difluoro-β-ketosulfone compounds. Background technique [0002] The fluorine atom has a large electronegativity and a small atomic radius, so introducing a single fluorine atom or multiple fluorine atoms into a compound can significantly change some characteristics and properties of the original compound, making the compound have many special physical and chemical properties. nature. Many fluorine-containing compounds have a wide range of applications in the fields of medicine, agriculture and materials. For example, in the field of materials, fluoropolymers have excellent properties such as good chemical stability and low surface energy, so they are widely used in the fields of rubber, resin, microelectronics industry and surfactants. Among the fluorine-containing compounds, α,α-difluoro-β-ketosulfone compounds are an important class o...

AI Technical Summary

Problems solved by technology

This reaction requires the use of expensive reaction instruments and photocatalysts, and due to the limitations of the preparation of 2,2-difluoroenol silyl ether, the functional group adaptability is poor

[0010] In summary, the current methods for the preparation of α,α-difluoro-β-ketosulfones face problems such as low chemoselectivity, harsh reaction conditions, and poor adaptability of functional groups.

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