Preparation method of medical surgical suture

A technique of surgical suture and silk thread, applied in the field of medical supplies, can solve the problems of low tensile strength and elongation, poor biocompatibility, incomplete absorption, etc., achieve high tensile strength, improve hydrophilicity and surface The degree of wetting, the effect of complete absorption

Inactive Publication Date: 2021-02-09
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prepared medical surgical suture overcomes the more or less low tensile strength and elongation, poor suture effect, poor biocompatibility, incomplete absorption, and easy stone formation of traditional surgical sutures in the prior art. It has the advantages of complete absorption, high tensile strength, good biocompatibility, can promote cell growth, and has the advantages of sterilization, anti-inflammation and hemostasis

Method used

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  • Preparation method of medical surgical suture
  • Preparation method of medical surgical suture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A medical surgical suture, which is composed of the following components by mass: 20 parts of 5-hydantoin acetic acid modified polylysine, 10 parts of polyethylene glycol hydroxy acid modified polylactic acid, sodium alginate based poly 45 parts of caprolactone copolymer, 10 parts of γ-cyclodextrin, 5 parts of hydroxybutyl methylcellulose.

[0030] The preparation method of the 5-hydantoin acetic acid modified poly-lysine comprises the following steps: dissolving 10 g of 5-hydantoin acetic acid in 100 g of methylene chloride to form a solution, and then adding 30 g of poly-lysine to the solution , 5g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 3g of 1-hydroxybenzotriazole, stirred and reacted at 60°C for 6 hours, and then evaporated to remove the solvent, And washed with ethanol and water for 3 times respectively, and then dried in a vacuum oven for 15 hours to obtain 5-hydantoin acetic acid modified polylysine.

[0031]The preparation method of the...

Embodiment 2

[0037] A medical surgical suture, which is composed of the following components by mass: 23 parts of 5-hydantoin acetic acid modified polylysine, 13 parts of polyethylene glycol hydroxy acid modified polylactic acid, sodium alginate based poly 48 parts of caprolactone copolymer, 13 parts of γ-cyclodextrin, 6 parts of hydroxybutyl methylcellulose.

[0038] The preparation method of the 5-hydantoin acetic acid modified poly-lysine comprises the following steps: dissolving 10 g of 5-hydantoin acetic acid in 115 g of ethyl acetate to form a solution, and then adding 35 g of poly-lysine to the solution , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 5g, 1-hydroxybenzotriazole 3g, stirred and reacted at 65°C for 6.5 hours, and then the solvent was removed by rotary evaporation, It was washed with ethanol and water for 4 times respectively, and then dried in a vacuum oven for 16 hours to obtain 5-hydantoin acetic acid-modified polylysine.

[0039] The preparation metho...

Embodiment 3

[0045] A medical surgical suture, which is composed of the following components by mass: 25 parts of 5-hydantoin acetic acid modified polylysine, 15 parts of polyethylene glycol hydroxy acid modified polylactic acid, sodium alginate based poly 50 parts of caprolactone copolymer, 15 parts of γ-cyclodextrin, 7 parts of hydroxybutyl methylcellulose.

[0046] The preparation method of the 5-hydantoin acetic acid modified poly-lysine comprises the following steps: dissolving 10 g of 5-hydantoin acetic acid in 130 g of dimethyl sulfoxide to form a solution, and then adding poly-lysine to the solution 40g, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 5g, 1-hydroxybenzotriazole 3g, stirred and reacted at 70°C for 7 hours, and then evaporated to remove the solvent , and washed with ethanol and water for 4 times respectively, and then placed in a vacuum drying oven for 17 hours to obtain 5-hydantoin acetic acid modified polylysine.

[0047] The preparation method of the ...

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Abstract

The invention discloses a preparation method of a medical surgical suture. The method comprises the following steps of adding 5-hydantoin acetic acid modified polylysine, polyethylene glycol hydroxy acid modified polylactic acid, a sodium alginate-based polycaprolactone copolymer, gamma-cyclodextrin and hydroxybutyl methyl cellulose into a high-speed mixer according to a mass ratio; mixing for 20-30 minutes at the rotating speed of 70-90 r / min to obtain a mixture; then feeding the mixture into a double-screw extruder, granulating, cooling, drying and cutting to obtain master batch; carrying out melt spinning on the master batch to form a silk thread with the diameter of 0.02-0.05 mm; and putting the silk thread into medical alcohol to be disinfected for 2-3h; and finally, performing vacuumdrying to obtain the medical surgical suture. The prepared medical surgical suture has the advantages of being complete in absorption, high in tensile strength, good in biocompatibility and capable of promoting cell growth and has the advantages of sterilizing, diminishing inflammation and stopping bleeding.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a medical surgical suture and a preparation method thereof. Background technique [0002] Medical surgical suture refers to the special thread used for ligation hemostasis, suture hemostasis and tissue suture in surgical operation or trauma treatment. It plays an important role in the initial wound healing. Generally, it can be divided into two types: absorbable suture and non-absorbable suture. Non-absorbable suture does not degrade in the body. It is degraded by acid, alkali or enzyme. The degradation rate depends on the temperature, pH value of the tissue and the liquid environment around the suture. Therefore, absorbable surgical sutures are the development trend of medical surgical sutures and have important application prospects. [0003] Absorbable sutures commonly used in the prior art can be divided into catgut, chemically synthesized sutures, and pure natural...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/12A61L17/14
CPCA61L17/005A61L17/10A61L17/105A61L17/12A61L17/14A61L2300/104A61L2300/204A61L2300/404A61L2300/41A61L2300/412A61L2400/04C08G81/00C08L5/16C08L77/02C08L51/00C08L1/28
Inventor 邓生卫
Owner 湖南博隽生物医药有限公司
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