Preparation, product and application of sandwich type degradable stent for alveolar bone repair

A sandwich type, alveolar bone technology, applied in coating, medical science, prosthesis, etc., can solve the problems of easy collapse of shape, unstable effect of alveolar bone and alveolar ridge height, non-degradable metal fixation, etc. Achieve the effect of improving compatibility and overcoming extramucosal exposure

Pending Publication Date: 2021-04-06
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current clinical operation, this technology is mainly filled with natural bone powder or artificial bone powder, supplemented by metal external fixation materials. When this method faces large bone tissue defects, the effect of bone augmentation is not ideal. The reason is that, on the one hand, powder fillings are subject to soft tissue extrusion and uneven self-dissolution process, and are prone to collapse in shape, resulting in unstable restoration of alveolar bone thickness and alveolar ridge height;

Method used

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  • Preparation, product and application of sandwich type degradable stent for alveolar bone repair
  • Preparation, product and application of sandwich type degradable stent for alveolar bone repair

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025]Example 1

[0026]A "sandwich" degradable bracket for the repair of tooth grooves, and the serialized hydroxyapatite and PLGA double-layer bracket are printed by double nozzle 3D; after the polyester surface is carbamlated, the EDC / NHS occasion is used. Filament protein coating of the endothelial growth drug is carried out, prepared according to the following steps:

[0027](1) Preparation of α-TCP:

[0028]Mass mole ratio 2: 1 weighing the calcium hydrogen phosphate powder and calcium carbonate powder, using an appropriate amount of anhydrous ethanol is dielectric wet ball mill, the rotational speed is 400 rpm, the ball milling time is 4 h, the ball grinder and the powder mass ratio are 2: 1. The raw material mixture removes ethanol by rotating evaporation, and is placed in an oven at 60 ° C for 24 h; then placed the dried powder in the muffle, and then taken out after calcination of 2 h at 1400 ° C, rapid cooling in the blast environment; powder after cooling powder With anhydrous ...

Example Embodiment

[0034]Example 2

[0035]A "sandwich" degradable bracket for the repair of the diarotic bone, and the 3D printing bracket is prepared according to the first step (1), (2), and the printing bracket is soaked in a water solution of 50% (v / v) ethanol. Ultrasound for 2 hours, then rinsed with a large amount of water, the cleaned bracket was placed in a mixed solution of 1, 6-hexanediamine and isopropyl alcohol at 45 ° C for 5 min, deionized water washing 12h, vacuum drying 24h. Get surface aminosaic brackets. The EDC / NHS / MES crosslinking agent is prepared, and the concentration is 20 mm / 10 mm / 10 mM, and a mixed solution of 0.1 g / ml silk fibroin and 2 μg / ml VEGF; crosslinked solution and mixed solution are mixed by volume ratio 1: 9. After, the PLGA aminocylated bracket was immediately soaked therein, and at 37 ° C for 4 h. After the reaction, the surface of the water washing bracket was performed, and the sandwich degradable bracket was obtained.

Example Embodiment

[0036]Example 3

[0037]A "sandwich" degradable bracket for the remedial remediation of the dental bone, and the 3D printing bracket is prepared in Example 1 (1), (2), so as soon as soon as the printing bracket is soaked in an ethanol solution of 50% (v / v). 2 hours, then rinsed with a lot of water, the cleaned bracket was placed in a mixed solution of 1, 6-hexanediamine and isopropanol, 5 min at 45 ° C, deionized water washed 12h, vacuum dry 24 h, obtained Surface aminocarblock. The EDC / NHS / MES crosslinking agent is prepared, the concentration is 20 mm / 10 mm / 10 mM, and the mixed solution of 0.1 g / ml silkase protein and 5 μg / ml of VEGF is compounded; the crosslinked solution is mixed with a mixed solution by volume ratio 1: 9. After, the PLGA aminocylated bracket was immediately soaked therein, and at 37 ° C for 4 h. After the reaction, the surface of the water washing bracket was performed, and the sandwich degradable bracket was obtained.

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Abstract

The invention relates to a preparation method of a sandwich type degradable stent for alveolar bone repair as well as a product and application thereof. The preparation method comprises the following steps: preparing a self-curing hydroxyapatite and PLGA double-layer stent through double-nozzle 3D printing; and afterwards, performing amination of the surface of the polyester, and chemically fixing the silk fibroin coating loaded with the endothelial growth promoting medicine through an EDC/NHS coupling reaction. The hydroxyapatite stent matched with bone trauma is prepared, the bioactive coating modified PLGA provides a matched base for external fixation of bone wounds, the hydroxyapatite stent is used in cooperation with bone glue, bone nails and suture lines to achieve the fixing effect, and accurate bone grafting is achieved. All the materials are biodegradable, the degradation rate of the materials is suitable for growth of new bones, the silk fibroin coating loaded with VEGF improves the compatibility of PLGA and mucous membranes, the defects that a traditional titanium mesh stent is exposed outside the mucous membranes in advance and cannot be degraded in vivo are overcome, and the requirements of clinical application are met.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to the preparation of a "sandwich" degradable scaffold for alveolar bone repair and its products and applications, through 3D printing technology and surface coating modification technology preparation. Background technique [0002] Dental implant technology is widely used in the restoration of dentition defects and missing teeth. However, the lack of alveolar bone leads to the lack of sufficient bone tissue in the implant area to provide stable support for the implant, which increases the difficulty of surgery and limits the ability of implant dentures. Scope of application [Lekovic V., et al, J. Periodontol., 1998]. The guided bone regeneration technology of dental implantology can effectively expand bone mass and restore the height and fullness of alveolar bone. In the current clinical operation, this technology is mainly filled with natural bone powder...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/12A61L27/18A61L27/22A61L27/54A61L27/58B33Y70/10
CPCA61L27/222A61L27/18A61L27/12A61L27/34A61L27/54A61L27/58B33Y70/10A61L2430/12A61L2300/414A61L2300/252C08L89/00C08L67/04
Inventor 崔大祥杨迪诚徐艳朱君
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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