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Preparation, product and application of sandwich type degradable stent for alveolar bone repair

A sandwich type, alveolar bone technology, applied in coating, medical science, prosthesis, etc., can solve the problems of easy collapse of shape, unstable effect of alveolar bone and alveolar ridge height, non-degradable metal fixation, etc. Achieve the effect of improving compatibility and overcoming extramucosal exposure

Pending Publication Date: 2021-04-06
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the current clinical operation, this technology is mainly filled with natural bone powder or artificial bone powder, supplemented by metal external fixation materials. When this method faces large bone tissue defects, the effect of bone augmentation is not ideal. The reason is that, on the one hand, powder fillings are subject to soft tissue extrusion and uneven self-dissolution process, and are prone to collapse in shape, resulting in unstable restoration of alveolar bone thickness and alveolar ridge height; on the other hand, due to the need to meet bone powder Most of the metal fixtures are mesh-covered design, and the surface of the traditional titanium mesh is not suitable for tissue adhesion, resulting in the incomplete coverage of the periosteum flap after the titanium mesh is implanted, and the postoperative submucosal titanium mesh The exposure rate is high; secondly, the metal fixation is not degradable, which may cause secondary trauma during the postoperative removal process, increasing the risk of surgery

Method used

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  • Preparation, product and application of sandwich type degradable stent for alveolar bone repair
  • Preparation, product and application of sandwich type degradable stent for alveolar bone repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A "sandwich" degradable scaffold for alveolar bone repair, prepared self-curing hydroxyapatite and PLGA double-layer scaffold by double-nozzle 3D printing; after that, the polyester surface was aminated, and the EDC / NHS couple was used to Combined reaction chemical immobilization of silk fibroin coating loaded with endothelial growth-promoting drugs, prepared according to the following steps:

[0027] (1) Preparation of α-TCP:

[0028] Dibasic calcium phosphate powder and calcium carbonate powder were weighed at a molar ratio of 2:1, and an appropriate amount of absolute ethanol was used as the medium for wet ball milling at a rotational speed of 400 rpm, ball milling time of 4 h, and a mass ratio of ball milling beads to powder of 2:1. The raw material mixture was removed by rotary evaporation to remove ethanol, and dried in an oven at 60°C for 24 hours; the dried powder was placed in a muffle furnace, calcined at 1400°C for 2 hours, taken out, and rapidly cooled in a ...

Embodiment 2

[0035] A "sandwich type" degradable scaffold for alveolar bone repair. Prepare a 3D printed scaffold according to steps (1) and (2) of Example 1, and soak the printed scaffold in 50% (v / v) ethanol aqueous solution Ultrasound for 2 hours, then rinse with a large amount of water, place the cleaned stent in a mixed solution of 1,6-hexanediamine and isopropanol at 45°C for 5 minutes, wash with deionized water for 12 hours, and dry in vacuum for 24 hours. A surface-aminated scaffold is obtained. Prepare EDC / NHS / MES cross-linking agent aqueous solution with a concentration of 20mM / 10mM / 10mM, and then prepare a mixed solution of 0.1g / mL silk fibroin and 2μg / mL VEGF; mix the cross-linking solution and the mixed solution at a volume ratio of 1:9 After that, the PLGA-aminated scaffold was soaked in it immediately, and reacted at 37°C for 4h. After the reaction, the surface of the stent is washed with water and freeze-dried to obtain a sandwich-type degradable stent.

Embodiment 3

[0037] A "sandwich" degradable scaffold for alveolar bone repair. Prepare 3D printed scaffolds according to Example 1 (1) and (2), soak the printed scaffolds in 50% (v / v) ethanol aqueous solution and ultrasonically 2 hours, then rinsed with a large amount of water, placed the cleaned stent in a mixed solution of 1,6-hexanediamine and isopropanol at 45°C for 5 minutes, washed with deionized water for 12 hours, and dried in vacuum for 24 hours to obtain Surface aminated scaffolds. Prepare EDC / NHS / MES cross-linking agent aqueous solution with a concentration of 20mM / 10mM / 10mM, and then prepare a mixed solution of 0.1g / mL silk fibroin and 5μg / mL VEGF; mix the cross-linking solution and the mixed solution at a volume ratio of 1:9 After that, the PLGA-aminated scaffold was soaked in it immediately, and reacted at 37°C for 4h. After the reaction, the surface of the stent is washed with water and freeze-dried to obtain a sandwich-type degradable stent.

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Abstract

The invention relates to a preparation method of a sandwich type degradable stent for alveolar bone repair as well as a product and application thereof. The preparation method comprises the following steps: preparing a self-curing hydroxyapatite and PLGA double-layer stent through double-nozzle 3D printing; and afterwards, performing amination of the surface of the polyester, and chemically fixing the silk fibroin coating loaded with the endothelial growth promoting medicine through an EDC / NHS coupling reaction. The hydroxyapatite stent matched with bone trauma is prepared, the bioactive coating modified PLGA provides a matched base for external fixation of bone wounds, the hydroxyapatite stent is used in cooperation with bone glue, bone nails and suture lines to achieve the fixing effect, and accurate bone grafting is achieved. All the materials are biodegradable, the degradation rate of the materials is suitable for growth of new bones, the silk fibroin coating loaded with VEGF improves the compatibility of PLGA and mucous membranes, the defects that a traditional titanium mesh stent is exposed outside the mucous membranes in advance and cannot be degraded in vivo are overcome, and the requirements of clinical application are met.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to the preparation of a "sandwich" degradable scaffold for alveolar bone repair and its products and applications, through 3D printing technology and surface coating modification technology preparation. Background technique [0002] Dental implant technology is widely used in the restoration of dentition defects and missing teeth. However, the lack of alveolar bone leads to the lack of sufficient bone tissue in the implant area to provide stable support for the implant, which increases the difficulty of surgery and limits the ability of implant dentures. Scope of application [Lekovic V., et al, J. Periodontol., 1998]. The guided bone regeneration technology of dental implantology can effectively expand bone mass and restore the height and fullness of alveolar bone. In the current clinical operation, this technology is mainly filled with natural bone powder...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/12A61L27/18A61L27/22A61L27/54A61L27/58B33Y70/10
CPCA61L27/222A61L27/18A61L27/12A61L27/34A61L27/54A61L27/58B33Y70/10A61L2430/12A61L2300/414A61L2300/252C08L89/00C08L67/04
Inventor 崔大祥杨迪诚徐艳朱君
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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