rhTSG6-FNIII-C fusion protein and application thereof in skin care composition and preparation method of the rhTSG6-FNIII-C fusion protein

A rhtsg6-fniii1-c, fusion protein technology, applied in the preparation methods of peptides, preparations for skin care, methods based on microorganisms, etc. The problem is to achieve the effect of simple preparation method, less skin allergy and low production cost
CN112876569AActive Publication Date: 2021-06-01WUHU TIANMING BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHU TIANMING BIOTECH CO LTD
Publication Date
2021-06-01

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Abstract

The invention relates to the technical field of cosmetics, and discloses an rhTSG6-FNIII-C fusion protein, an application of the rhTSG6-FNIII-C fusion protein in a skin care composition and a preparation method of the rhTSG6-FNIII-C fusion protein. The rhTSG6-FNIII-C fusion protein is prepared through a genetic engineering prokaryotic expression technology. The specific method comprises the following steps: carrying out codon optimization on a gene sequence of SEQ ID NO: 1; constructing a recombinant expression vector and transforming; inducing and expressing the recombinant Escherichia coli; and separating and purifying an expression product, so that the rhTSG6-FNIII-C fusion protein is prepared. The skin care composition has various dosage forms, such as an aqueous solution, an ointment, a suppository, a cream and a mask, and has good skin care effects of improving skin wrinkles, keeping skin elasticity, reducing skin inflammation and allergy risks and the like, so that the skin care composition can be applied to the field of functional cosmetics or medical cosmetology.
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Description

technical field

[0001] The invention relates to a recombinant human tumor necrosis factor α-stimulated gene-6-fibronectin Ⅲ 1-C (recombination human tumor necrosis factor α-stimulated gene-6-fibronectin Ⅲ 1-C, rhTSG6-FN Ⅲ 1) capable of enhancing skin cell proliferation and skin tissue repair -C) a fusion protein, and a skin care composition for improving skin wrinkles, maintaining skin elasticity, and reducing skin inflammation and allergies. It contains the same active ingredients. Background technique

[0002] Human skin is composed of epidermis, dermis, subcutaneous tissue and skin appendages, and has functions such as protection, temperature regulation, metabolism and sensation. The state of the epidermis and dermis is closely related to the state of the skin, and the homeostasis of the cellular environment composed of cells and extracellular matrix is ​​related to the state of the skin.

[0003] Fibronectin (FN) is a high molecular weight (about 440kDa) dimeric glycop...

Claims

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