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Composition for increasing bone mineral density as well as health care product and preparation method thereof

A technology for increasing bone density and health care products, applied in the direction of drug combinations, food ingredients containing natural extracts, medical preparations with non-active ingredients, etc., can solve problems affecting the life span and quality of life of the elderly, and increase medical expenses, etc., to achieve Promote the proliferation of osteoblasts, improve synergistic effect, and increase bone density

Inactive Publication Date: 2021-06-15
NINGBO YUFANGTANG BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The chronic pain and resulting fractures and other complications of osteoporosis seriously affect the longevity and quality of life of the elderly, and increase the related medical costs

Method used

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  • Composition for increasing bone mineral density as well as health care product and preparation method thereof
  • Composition for increasing bone mineral density as well as health care product and preparation method thereof
  • Composition for increasing bone mineral density as well as health care product and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Study on Eucommia Extraction Technology

[0028] 1-1 Determination of the best cooking conditions

[0029] In order to determine the optimum decocting condition of Eucommia ulmoides, the extraction rate of solid matter (%) was used as the investigation index, and L 9 (3 4 ) table carries out the orthogonal experiment to decocting number of times (A), decocting time (B) and water addition (C) three factors, each factor all screens three levels, sees the following table 1. Take 100 g of Eucommia ulmoides, decoct, filter and concentrate to a certain volume according to the experimental arrangement in Table 1. The solids in each test sample were measured, the results and visual analysis are shown in Table 2, and the results of variance analysis are shown in Table 3.

[0030] Table 1 Test factor level table

[0031]

[0032]

[0033] Table 2L 9 (3 4 ) experimental arrangement, experimental results and data processing table

[0034]

[0035] Table 3...

Embodiment 2

[0048] Embodiment 2: the preparation of the health product among the present invention

[0049] (1) Preparation of Eucommia ulmoides extract (refer to the preparation method obtained in Example 1 above):

[0050] Decommia ulmoides 8 times the amount of water decoction twice, 1.5 hours each time, filter out the drug solution, discard the drug residue, combine the drug solution, concentrate to a density of 1.02-1.05g / ml, to obtain the Eucommia extract; spray the above extract Drying, the air inlet temperature is 180-200°C, and the Eucommia extract is obtained.

[0051] (2) Mix the raw materials and auxiliary materials evenly according to the following parts: 12.8-19.2 parts of glucosamine hydrochloride, 10.4-15.6 parts of marine fish bone glue oligopeptide, 6.4-9.6 parts of sodium chondroitin sulfate, 4.8-19.6 parts of eucommia extract 7.2 parts microcrystalline cellulose 13.68-20.52 parts, povidone K30 3.2-4.8 parts.

[0052] (3) After the above raw and auxiliary materials ar...

Embodiment 3

[0054] Embodiment 3: toxicity test

[0055] In this embodiment, the health products prepared in the above-mentioned embodiment 2 (the dosage form adopted in this embodiment is a tablet) have carried out the first and second stage toxicity tests, including rat acute oral toxicity test, Ames test, mouse bone marrow Polychromatic erythrocyte micronucleus test, sperm abnormality test in mice and 30-day feeding test in rats. The acute oral toxicity test and the 30-day feeding test used SPF grade SD rats, which were purchased from the Experimental Animal Center of Sichuan Academy of Traditional Chinese Medicine, with half male and half male. SPF-grade Kunming mice were used for the micronucleus test, half male and half female, and SPF-grade Kunming male mice were used for the sperm abnormality test, all of which were purchased from Chengdu Dashuo Experimental Animal Co., Ltd.

[0056] The acute toxicity test of present embodiment: establish 15g / kg.bm dosage group, do not see animal...

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Abstract

The invention relates to a composition for increasing bone mineral density as well as a health care product and a preparation method thereof. The composition is prepared from the following components in parts by mass: 12.8 to 19.2 parts of glucosamine hydrochloride, 10.4 to 15.6 parts of marine fishbone collagen oligopeptide, 6.4 to 9.6 parts of sodium chondroitin sulfate and 4.8 to 7.2 parts of cortex eucommiae extract. The components of the composition cooperate to effectively increase the bone mineral density and prevent osteoporosis, the health care product prepared from the composition has no toxic or side effect, and the effect of increasing the bone mineral density is remarkable. According to the preparation method disclosed by the invention, microcrystalline cellulose and povidone K30 are added, wet granulation is performed, and a required dosage form is processed. By adjusting the proportional relation of raw materials and auxiliary materials and optimizing wet granulation, a good synergistic improvement effect is achieved among the raw material medicines, that is, after the components are combined, the drug effect is remarkably improved compared with that when the components are independently used, and the drug effect is more durable.

Description

technical field [0001] The invention relates to the field of health care products, in particular to a composition for increasing bone density, health care products and a preparation method thereof. Background technique [0002] The full name of bone mineral density is bone mineral density, which is an important indicator of bone strength, expressed in grams per cubic centimeter, and is an absolute value. When using bone density values ​​clinically, because the absolute values ​​of different bone density detectors are different, the T value is usually used to judge whether the bone density is normal. T value is a relative value, and the normal reference value is between -1 and +1. When the T value is lower than -2.5, it is abnormal. When the T value is abnormal, it will lead to osteoporosis. [0003] Furthermore, osteoporosis is a systemic skeletal disease characterized by decreased bone mass and damage to the microstructure of bone tissue, which in turn leads to increased b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K36/46A61K31/7008A61K31/737A61K9/16A61K9/20A61K9/48A61K47/38A61K47/32A61P19/10A23L33/125A23L33/18A23L33/105A23L29/30A23L29/00A23P10/20A23P10/28
CPCA61K38/012A61K31/7008A61K31/737A61K36/46A61K9/1635A61K9/1652A61K9/2027A61K9/2054A61K9/4866A61P19/10A23L33/125A23L33/18A23L33/105A23L29/30A23L29/045A23L29/035A23P10/20A23P10/28A23V2002/00A61K2300/00A23V2200/306A23V2250/55A23V2250/51A23V2250/21A23V2250/51084A23V2300/14A23V2250/082
Inventor 贾福怀周丹英涂宏建王俊姜艳熊菲菲朱琦陶刚陆伟
Owner NINGBO YUFANGTANG BIOTECH
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