Preparation method of medical polymer material surface antifouling coating

A polymer material, antifouling coating technology, applied in antifouling/underwater coatings, coatings, paints containing biocides, etc., can solve the problem of difficult surface functionalization, and achieve easy industrial application and high reaction efficiency Effect

Active Publication Date: 2021-08-03
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of the present invention is that the formed polyvinylbenzyl chloride coating has similar polarity to the medical polymer material, so the interface between the two can be highly fused without phase separation, so the formed polyvinylbenzyl chloride coating The layer is extremely stable, thus solving the problem that the surface of polyolefin medical polymer materials is not easy to be functionalized

Method used

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  • Preparation method of medical polymer material surface antifouling coating
  • Preparation method of medical polymer material surface antifouling coating
  • Preparation method of medical polymer material surface antifouling coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Immerse a 2cmx2cm medical polystyrene sheet in a dichloromethane solution of 0.01% azobisisobutyronitrile and 1% vinylbenzyl chloride, take it out after 5 seconds, and irradiate it quickly at an ultraviolet light intensity of 50 mW / cm2 500 seconds, initiate the polymerization of vinylbenzyl chloride, and form a nano-layer of polyvinylbenzyl chloride on the surface of polystyrene; then under nitrogen atmosphere, use 0.001M cuprous chloride catalyst and 0.002M BPY as ligand , 3M aqueous solution of methacryloyl ethyl sulfobetaine is the ATRP reaction system, the above-mentioned medical polystyrene sheet is placed in the system to carry out ATRP grafting of betaine on the surface, at 25 degrees Celsius, the oscillation reaction time is 12 hours, After taking out the polystyrene sheet, immerse it in deionized water for 2 hours to remove copper ions, and measure the contact angle of water to be 30 o (Unmodified polystyrene has a contact angle of 100 o ), so as to obtain the...

Embodiment 2

[0020] Immerse a 2 cmx2 cm medical polypropylene sheet in a chloroform solution of 0.04% benzoyl peroxide and 4% vinylbenzyl chloride, take it out after 60 seconds, and irradiate it quickly at an ultraviolet light intensity of 0.5 mW / cm2 for 10 Seconds, the polymerization of vinyl benzyl chloride is initiated, and a nano-vinyl benzyl chloride layer is formed on the surface of the polypropylene sheet; then, under nitrogen atmosphere, with 0.01M cuprous bromide as the catalyst and 0.02M HMTETA as the ligand, The 3M aqueous solution of 2-methacryloyloxyethylphosphorylcholine is the ATRP reaction system. The above-mentioned medical polypropylene material is placed in the system for surface ATRP grafting reaction. At 90 degrees Celsius, the oscillation reaction time is 8 hours. Take out the medical polypropylene sheet, soak it with deionized water for 2 hours to remove copper ions, and measure the contact angle of water to be 20 o (Note that the contact angle of unmodified polystyr...

Embodiment 3

[0022] Immerse a 2cmx2cm medical polyvinyl chloride sheet in a chloroform solution of 0.02% benzoyl peroxide and 2% vinylbenzyl chloride, take it out after 40 seconds, and irradiate it at an ultraviolet light intensity of 25mW / cm2 for 200 seconds quickly. Initiate the polymerization of vinylbenzyl chloride, and form a nano-layer of polyvinylbenzyl chloride on the surface of the polyvinyl chloride sheet; then, under nitrogen atmosphere, use 0.005M cuprous bromide as the catalyst and 0.01M HMTETA as the ligand, 1M The aqueous solution of hydroxyethyl methacrylate is an ATRP reaction system. The above-mentioned medical polyvinyl chloride material is placed in the system for surface ATRP grafting reaction. At 70 degrees Celsius, the oscillation reaction time is 1 hour, and the medical polyvinyl chloride sheet is taken out. Immerse with deionized water for 2 hours to remove copper ions, and measure the contact angle of water to be 35 o (Note that the contact angle of unmodified pol...

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Abstract

The invention discloses a preparation method of a medical polymer material surface antifouling coating, which mainly comprises the following steps of dipping a polymer material in an organic solution containing azodiisobutyronitrile or benzoyl peroxide and vinyl benzyl chloride for a certain time, then taking out the polymer material, and rapidly irradiating the polymer material for 10-500 seconds under the ultraviolet light intensity value of 0.5-50 mW / cm<2> to initiate free radical polymerization, forming a polyvinyl benzyl chloride nano layer on the surface of a polymer material, then taking benzyl chloride as an initiator, grafting hydrophilic antifouling components in a water phase through ATRP, forming a stable antifouling coating, and reducing adsorption of biomacromolecules and bacteria. The method is simple and easy to implement, is suitable for industrial preparation of antibacterial and antifouling coatings on the surfaces of high-molecular medical apparatuses and instruments, and has a very wide application prospect.

Description

technical field [0001] The invention belongs to the field of surface modification of polymer materials, in particular to a preparation method of an antibacterial and antifouling coating on the surface of medical polymer materials. Background technique [0002] The antibacterial performance of the surface of biomedical polymer device materials is an important indicator to measure its medical safety. According to statistics, in medical operations, 30% of postoperative bacterial infections are caused by the lack of antibacterial performance on the surface of medical devices during the operation. Therefore Improving the antifouling performance of medical polymer materials through surface modification is an important means to solve the above problems. Grafting anti-fouling materials on the surface of polymer materials in the water phase is an ideal process method, which can avoid the influence of organic solvents on hydrophobic medical polymer materials. However, due to the iner...

Claims

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Application Information

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IPC IPC(8): C08J7/18C09D5/14C09D5/16C09D125/18C09D133/14C09D133/24C08L25/06C08L23/12C08L27/06C08L75/04
CPCC08J7/18C09D5/14C09D5/1662C09D125/18C09D133/14C09D133/24C09D133/066C08J2325/06C08J2323/12C08J2327/06C08J2375/04C08J2425/18C08J2433/14C08J2433/24
Inventor 孙秀花吴予玮高昌录
Owner HARBIN INST OF TECH AT WEIHAI
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