Application of bifidobacterium lactis JYBR-190 in product for removing heavy metals in body

A technology of JYBR-190 and Bifidobacterium lactis, applied in the fields of application, function of food ingredients, bacteria, etc., can solve problems such as loss of beneficial metal ions, inability to actively remove arsenic treatment, and many adverse reactions

Active Publication Date: 2021-08-17
WEIFANG ZHONGKEJIAYI BIO FODDER TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The drugs currently used to treat lead poisoning are mainly chelating lead repellents, such as: sodium dimercaptosuccinate (NaDMS), calcium sodium edetate (NaDMS), 2 Ca-EDTA), Ca-DTPA, etc. The principle of action of chelating lead-dispelling agents is to form coordination compounds through sulfhydryl or carboxyl groups to achieve the purpose of lead-dispelling. However, these drugs have certain limitations in clinical application. Side effects, such as the low detoxification rate after long-term use of calcium sodium edetate, and some patients may experience transient dizziness, joint pain, abdominal pain, nausea, fatigue and other symptoms; when used in large doses, patients may experience damage such as renal tubular edema
The current clinical treatment of acute mercury poisoning generally uses the metal ion chelating agent dimercaptopropanesulfonate (DMPS). Although this drug can combine with mercury ions, it also binds Ca in the body 2+ , Zn 2+ and other beneficial metal ions, resulting in the loss of beneficial me

Method used

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  • Application of bifidobacterium lactis JYBR-190 in product for removing heavy metals in body
  • Application of bifidobacterium lactis JYBR-190 in product for removing heavy metals in body
  • Application of bifidobacterium lactis JYBR-190 in product for removing heavy metals in body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of bifidobacterium lactis JYBR-190, the screening process of this bacterial strain JYBR-190 is as follows:

[0029] (1) Preparation of MRS plate medium: peptone 10g, beef powder 5g, longibacterium powder 4g, K 2 HPO 4 ·7H 2 O 2g, triammonium citrate 2g, sodium acetate trihydrate 5g, glucose 20g, Tween 80 1mL, MgSO 4 ·7H 2 O 0.2g, MnSO 4 4H 2 O0.05g, 15g agar, 1000mL distilled water, mix well, sterilize at 121°C for 20min, let cool, and set aside;

[0030] (2) Isolation and identification of strains:

[0031] 1) Weigh 5g of naturally fermented yogurt from a herdsman's home in Yili Prefecture, Xinjiang under aseptic conditions, add the yogurt to 45mL of 0.85% sterilized physiological saline containing glass beads, and mix well to obtain a mother liquor;

[0032] 2) Shake the mother solution for 10 minutes at a speed of 1500 rpm, and then take 1mL of the mother solution under sterile conditions to dilute with a 10-fold gradient to form a dilution; choose 10 ...

Embodiment 2

[0036] The preparation process of Bifidobacterium lactis JYBR-190 bacterium powder is as follows:

[0037] (1) Pick a single colony of newly cultured Bifidobacterium lactis JYBR-190 from the MRS plate in Example 1, inoculate it in MRS liquid medium with an inoculum size of 1%, and culture it at 37°C for 24 hours to obtain bacteria liquid;

[0038] Among them, the MRS liquid medium includes peptone 10g, beef powder 5g, longibacterium powder 4g, K 2 HPO 4 ·7H 2 O2g, triammonium citrate 2g, sodium acetate trihydrate 5g, glucose 20g, Tween 80 1mL, MgSO 4 ·7H 2 O 0.2g, MnSO 4 4H 2 O 0.05g, distilled water 1000mL;

[0039] (2) Using aseptic operation, the bacterial solution was centrifuged and washed with sterile saline, then resuspended in 10% (w / w) sterile reconstituted skim milk, and the concentration was adjusted to 1.0×10 10 cfu / mL, obtain the bacterial suspension, freeze-dry the bacterial suspension to obtain the freeze-dried powder;

[0040] (3) Mix the freeze-dried ...

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Abstract

The invention provides an application of bifidobacterium lactis JYBR-190 in a product for removing heavy metals in a body. The Bifidobacterium lactis JYBR-190 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 8, 2019, the address is No.3, yard 1, Beichen West Road, Chaoyang District, Beijing, the postal code is 100101, and the preservation number is CGMCC NO.18092. The strain JYBR-190 belongs to probiotics and has the advantages of high efficiency, safety and no toxic or side effect when being applied to elimination of vivotoxin by adjusting the balance of human flora.

Description

technical field [0001] The invention relates to the technical field of biological applications, in particular to the application of bifidobacterium lactis JYBR-190 in products for eliminating heavy metals in the body. Background technique [0002] Heavy metals are a class of metal elements that are seriously harmful to the human body, and can cause serious damage to the tissues, organs and nervous system of the body. Studies have shown that excessive blood lead can cause fetal / infant / children's nervous system and mental development to be blocked. Significant decline in IQ. The heavy metal element arsenic exists widely in the surface, water, atmosphere, soil, food and living organisms in the form of compounds; mercury can exist in the body in the form of ions, which leads to digestive disorders in the body, a decrease in the absorption rate of food, and weight loss; in addition Mercury can also flow through the whole body along with the blood circulation, and accumulate in t...

Claims

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Application Information

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IPC IPC(8): A61K35/745A61P39/02A23L33/135C12N1/20C12R1/01
CPCA23V2002/00A61K35/745A23L33/135A61P39/02C12N1/20A23V2200/30
Inventor 潘仕城侯建亮潘玉林曹维超李翠华刘红亮司书锋孙川周文浩步敏
Owner WEIFANG ZHONGKEJIAYI BIO FODDER TECH
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