Method for improving aerobic composting effect of cephalosporin fermentation mushroom dregs by using electron beam irradiation

An electron beam irradiation, cephalosporin technology, applied in the application, fertilization device, radiation treatment and other directions, can solve the problems of slow degradation of antibiotics, prolonged composting time, affecting safety, etc. No effect of drug-resistant bacterial contamination

Active Publication Date: 2021-09-07
TSINGHUA UNIV
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Problems solved by technology

The main problems faced by the aerobic composting of antibiotic residues are as follows: one is that the residual antibiotics in the residues can inhibit and poison microorganisms, which prolongs the composting time and slows down the degradation of antibiotics; the ot

Method used

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  • Method for improving aerobic composting effect of cephalosporin fermentation mushroom dregs by using electron beam irradiation
  • Method for improving aerobic composting effect of cephalosporin fermentation mushroom dregs by using electron beam irradiation
  • Method for improving aerobic composting effect of cephalosporin fermentation mushroom dregs by using electron beam irradiation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The fermentation residue of cephalosporin C was taken from an antibiotic production enterprise in Xinjiang. Its water content was 90%, the C / N ratio was 4.7, the pH value was 3.5, and the volatile suspended solids (VSS / total suspended solids (TSS) ratio was 94. %, protein and polysaccharide content were 10g / kg and 31g / kg.

[0037] The original sample-I of cephalosporin fermentation residue and the compost sample-II after electron beam irradiation were tested respectively.

[0038] CPCs were first extracted with phosphate buffered saline (PBS), and detected by liquid chromatography. Wherein, the liquid chromatograph used is a high-performance liquid chromatograph (Agilent 1200) from Agilent Company of the United States, the chromatographic column is an XDB-C18 reversed-phase column, and the column temperature is 30°C. The detector is an ultraviolet detector, and the detection wavelength is 260nm; the mobile phase is acetonitrile and 0.1% formic acid aqueous solution, an...

Embodiment 2

[0062] The DOCPC fermentation residue was taken from an antibiotic production enterprise in Xinjiang. Its water content was 91%, the C / N ratio was 5.4, the pH value was 3.5-4.0, and the volatile suspended solids (VSS) / total suspended solids (TSS) ratio was 87.7 %, protein and polysaccharide content were 23.2g / kg and 19.6g / kg.

[0063] 1) The DOCPC fermented bacteria residue is firstly treated with electron beam irradiation, and its specific process is:

[0064] Take about 5kg of bacteria residue and put it into a sample bag, spread it into a thin layer to expand the irradiation area and make the irradiation more uniform and sufficient; then send it to the irradiation room of the electron accelerator for irradiation by a conveyor belt and transmission speed to obtain different absorbed radiation doses of 0, 5kGy, 10kGy, 25kGy and 50kGy. The concentration of DOCPC, protein and polysaccharide in the bacteria residue before and after irradiation were detected respectively.

[00...

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Abstract

The invention discloses a method for improving the aerobic composting effect of cephalosporin fermentation mushroom dregs by using electron beam irradiation, and belongs to the technical field of solid waste treatment and disposal. The method comprises the following steps: carrying out electron beam irradiation pretreatment on the cephalosporin zymophyte residues; mixing with solid waste, adding a microbial agent, uniformly mixing, and carrying out aerobic composting fermentation to prepare a fertilizer; while in the electron beam irradiation process, the abundance of drug-resistant bacteria and cephalosporin resistance genes in the cephalosporin fermentation fungus residues is reduced, the proliferation of resistance genes in the composting process is inhibited and killed. According to the pretreated aerobic compost, the composting time can be shortened, the compost product is free of antibiotic residues, the abundance of resistance genes is remarkably reduced, no drug-resistant bacteria are detected, and the compost product can be safely recycled as a fertilizer.

Description

technical field [0001] The invention belongs to the technical field of solid waste treatment and disposal, and in particular relates to a method for improving the aerobic composting effect of cephalosporin fermentation slag by using electron beam irradiation. Background technique [0002] my country is the world's largest producer of antibiotic raw materials, accounting for more than 70% of the global market. Most antibiotics (including β-lactams such as cephalosporin and penicillin, tetracyclines such as tetracycline and oxytetracycline, aminoglycosides such as streptomycin and gentamicin, and macrolide antibiotics such as erythromycin and azithromycin) The raw materials of the company are all produced by microbial fermentation, which produces a large amount of antibiotic fermentation residue. In the product structure of antibiotic raw materials, cephalosporins and penicillins β-lactam antibiotics occupy the vast majority. According to reports, the output of β-lactam anti...

Claims

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Application Information

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IPC IPC(8): C05G3/80C05F17/30
CPCC05F3/00C05F17/30C05G3/80C05F5/008C05F11/00Y02W30/40
Inventor 王建龙初里冰
Owner TSINGHUA UNIV
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