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Preparation method of drug-loaded capsule with core-shell structure

A core-shell structure and drug-carrying technology, applied in the field of pesticides, can solve problems such as easy rupture of drug-carrying capsule shells

Active Publication Date: 2021-09-10
SHANDONG AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to make up for the deficiencies of the prior art and solve the problem that the capsule shell of the drug-loaded capsule prepared by the electrostatic self-assembly method in the prior art is easy to break, the present invention provides a method for preparing a drug-loaded capsule with a core-shell structure

Method used

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  • Preparation method of drug-loaded capsule with core-shell structure
  • Preparation method of drug-loaded capsule with core-shell structure
  • Preparation method of drug-loaded capsule with core-shell structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050]2.6g lambda-cyhalothrin technical substance (96%) is dissolved in 5g cyclohexanone as oil phase; With 0.2g polyvinyl alcohol, 0.5g calcium dodecylbenzenesulfonate, 2.4g sodium lignosulfonate Dissolve in deionized water to form the aqueous phase. Add the oil phase to the water phase under magnetic stirring at 400 rpm to form an oil-in-water emulsion; slowly add 2 g of octadecyldimethylbenzyl ammonium chloride to the above emulsion, and stir for 20 minutes; Then add 0.1g10% ferric chloride aqueous solution; stir for 20 minutes; then add 0.1g xanthan gum, 2g ethylene glycol, and deionized water to make up 100g; promptly make 2.5% lambda-cyhalothrin microcapsule suspension, the obtained Scanning electron microscope images of drug-loaded microcapsules image 3 as shown in image 3 As shown, in the microcapsule suspension obtained in the present invention, the microcapsules are all stable spheres, and no crystals of the original drug are seen to separate out, indicating that...

Embodiment 2

[0054] 5.26g Abamectin former drug (95%) is dissolved in 15g cyclohexanone as oil phase; With 0.3g polyvinyl alcohol, 0.8g sodium dodecylbenzenesulfonate, 2g calcium lignosulfonate is dissolved in An aqueous phase is formed in ionized water. Add the oil phase to the water phase under magnetic stirring at 400 rpm to form an oil-in-water emulsion; then add 2.5g of tetradecyldimethylbenzyl ammonium chloride and slowly add it to the above emulsion, and stir for 20 minutes; Then add 0.2g10% copper chloride aqueous solution; stir for 20 minutes; then add 0.1g xanthan gum, 2g ethylene glycol, and deionized water to make up 100g; promptly make 5% abamectin nanocapsule suspension.

[0055] After testing, the average particle diameter of the preparation is 254nm, the encapsulation rate is 94%, the suspension rate is >95%, and the low temperature stability and thermal storage stability are all qualified.

Embodiment 3

[0057] 1.41g emamectin benzoate former medicine (71%) is dissolved in 10g cyclohexanone as oil phase; With 0.3g polyvinyl alcohol, 0.8g sodium dodecylbenzenesulfonate, 2g lignin Calcium sulfonate was dissolved in deionized water to form an aqueous phase. Add the oil phase to the water phase under magnetic stirring at 400 rpm to form an oil-in-water emulsion; then add 2.5 g of dioctadecylmethylbenzyl ammonium chloride and slowly add it to the above emulsion, and stir for 20 minutes; Then add 0.2g10% ferric chloride aqueous solution; stir for 20 minutes; then add 0.1g xanthan gum, 2g ethylene glycol, and deionized water to make up 100g; promptly make 1% emamectin benzoate micro capsule suspension.

[0058] After testing, the average particle size of the preparation is 305nm, the encapsulation rate is 95%, the suspension rate is >98%, and the low temperature stability and thermal storage stability are all qualified.

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Abstract

The invention discloses a preparation method of a drug-loaded capsule with a core-shell structure, and belongs to the technical field of pesticides. According to the invention, an oil-in-water emulsion is adopted as a template, an oil phase containing a pesticide active ingredient is emulsified and dispersed into a water phase containing a colloid protective agent and an anionic monomer with negative charges, a cationic monomer is added, a prototype of a capsule shell is formed through electrostatic attraction, and the capsule shell is cured by using the chelation of the metal ions and phenolic hydroxyl groups on the lignin to form the drug-loaded microcapsule, wherein the solidification of metal ions plays a crucial role in stabilization of the capsule shell, and the stable carrier endows the drug delivery system with the ability to resist environmental adverse factors, so that the drug delivery system has a controlled release function; and the microcapsule exists in water, and an anti-settling agent and an anti-freezing agent are added to form a microcapsule suspending agent, wherein the capsule core is a pesticide active ingredient or a mixture of the pesticide active ingredient and an organic solvent, and the capsule shell is a carrier formed by an anion component, a cation component and metal ions.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to a method for preparing drug-loaded capsules with a core-shell structure. Background technique [0002] Pesticides play an irreplaceable role in the control of crop diseases, insect pests and weeds and yield control in modern agriculture. However, the problem of low pesticide utilization has always existed, which not only increases the cost of pesticide use, but also poses a threat to the environment and human health. At present, the controlled-release drug delivery system of pesticides has been developed and utilized, and has shown great application potential in improving the utilization rate of pesticides and prolonging the effective period. However, controlled-release pesticides still have disadvantages such as cumbersome preparation process, toxic raw materials, refractory carrier materials, and inability to release on demand. Therefore, it is urgent to develop a preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N25/08A01N43/90A01N53/08A01N47/24A01N37/46A01P3/00A01P1/00
CPCA01N25/04A01N25/08A01N43/90A01N53/00A01N47/24A01N37/46
Inventor 刘峰慕卫张大侠王瑞李北兴
Owner SHANDONG AGRICULTURAL UNIVERSITY