Novel application of compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule for treating hyperuricemia and gout kidney

A technology for hyperuricemia and gout, applied in the new application of treating hyperuricemia and gouty kidney, in the field of Fufang Zhenzhu Tiaozhi Capsules, which can solve the problems of fatal skin rash, increased death of cardiovascular disease, liver failure and other problems

Inactive Publication Date: 2021-09-10
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are a large number of adverse reactions during the treatment of these western medicines: allopurinol can cause fatal skin rashes, and its higher starting dose is one of the risk factors for adverse reactions; febuxostat also has abnormal liver function and increase the risk of death from cardiovascular disease, and even liver failure in severe cases; benzbromarone is often accompanied by gastrointestinal discomfort in the treatment of gout, specifically manifested as vomiting, diarrhea and other symptoms, and its abnormal liver function is also worthy of attention. focus on

Method used

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  • Novel application of compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule for treating hyperuricemia and gout kidney
  • Novel application of compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule for treating hyperuricemia and gout kidney
  • Novel application of compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule for treating hyperuricemia and gout kidney

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Example 1 FTZ improves hyperuricemia and gouty nephropathy in mice induced by Hx combined with OXO

[0093] 1. FTZ improves hyperuricemia induced by Hx combined with OXO

[0094] Serum uric acid concentration was used to evaluate the severity of hyperuricemia. The urine uric acid concentration reflects the excretion of uric acid in the body. Xanthine oxidase is an important enzyme in nucleic acid metabolism in vivo, which can catalyze hypoxanthine to generate uric acid and hydrogen peroxide, and is one of the important enzymes in nucleic acid metabolism in vivo. The result is as figure 1 As shown, where A is the test result of serum uric acid (SUA), B is the test result of urine uric acid (UUA), and C is the test result of xanthine oxidase (XOD) in serum. The results showed that the SUA of hyperuricemia mice (HN) was significantly increased, UUA decreased, XOD activity was up-regulated, uric acid synthesis increased, and uric acid levels in mice increased, indicating...

Embodiment 2

[0112] Example 2 FTZ improves renal tubular epithelial cell injury induced by UA

[0113] 1. Culture and passage of human renal tubular epithelial cells (HK-2)

[0114] Under the condition of ensuring that the cell culture and operation process are in a sterile environment, HK-2 cells were cultured in DMEM complete medium containing 10% fetal bovine serum, 1% penicillin and streptomycin, placed at 37°C, 5% CO2, cultivated in an incubator with saturated humidity;

[0115] When the cell growth density reaches 75-85%, it can be subcultured;

[0116] Place the required reagents in the ultra-clean bench in advance, irradiate with ultraviolet light for more than half an hour, and carry out passage operation after ventilation;

[0117] Use a pipette to suck off the culture medium, then add PBS to the dish to wash 3 times, and use a pipette to dry up the remaining liquid;

[0118] Add 0.05% trypsin to the petri dish and digest in the incubator for 90 seconds;

[0119] At this poin...

Embodiment 3

[0136] Example 3 Hepatotoxicity of FTZ

[0137] The present embodiment has evaluated the hepatotoxicity of FTZ, and the results are as follows: Figure 16 As shown, where A is the staining result, and B is the content of ALT in serum. The results showed that by HE staining, the liver morphology of the normal group, the model group and each administration group was normal; ALT in the serum reflected the liver function, and it was not significantly up-regulated. Therefore, FTZ does not cause liver damage in the treatment of hyperuricemia and gouty nephropathy.

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a novel application of a compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule for treating hyperuricemia and gout kidney. The invention finds that traditional Chinese medicine composition consisting of fructus ligustri lucidi, herba cirsii japonici, rhizoma atractylodis, radix salviae miltiorrhizae, cortex eucommiae, fructus citrus sarcodactylis, notoginseng radix et rhizoma and rhizoma coptidis and the compound fructus ligustri lucidi and rhizoma atractylodis lipid regulating capsule prepared by adopting the formula of the traditional Chinese medicine composition can obviously lower the serum uric acid level and relieve kidney collagen deposition and inflammatory response. improve gouty kidney injury and fibrosis, improve hyperuricemia and uricate deposition of gouty nephropathy, and has a relatively obvious effect of treating hyperuricemia and gouty nephropathy. The capsule can be used for treating various complications such as gout, hyperuricemia, gouty nephropathy, gouty arthritis and uric acid calculus; the long-term effect of the capsule is superior to that of allopurinol and benzbromarone; and the capsule is basically free of hepatotoxicity and good in safety.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a new application of compound Zhenzhu Tiaozhi capsule for treating hyperuricemia and gouty kidney. Background technique [0002] Hyperuricemia mainly occurs in advanced primates including humans, mainly because primates have undergone mutations in the uricase gene during evolution and cannot biotransform uric acid produced by normal metabolism, uric acid It becomes the final product of purine metabolism in the body and accumulates in the blood, causing the blood uric acid level to rise. Under normal circumstances, the purine nucleotides in the human body undergo a series of hydrolysis, deamination, and oxidation to generate uric acid. The daily new generation and excretion of uric acid in the human body are basically the same, which is a state of dynamic balance. After uric acid is synthesized in the liver, about 70% is secreted and metabolized in the ki...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61K9/48A61P19/06A61P3/06A61P13/04A61P13/12A61P19/02
CPCA61K36/638A61K36/28A61K36/284A61K36/537A61K36/46A61K36/752A61K36/258A61K36/718A61K9/48A61P19/06A61P3/06A61P13/04A61P13/12A61P19/02A61K2300/00
Inventor 郭姣兰天
Owner GUANGDONG PHARMA UNIV
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