Preparation method of macromolecular antibacterial microspheres

Abstract

The invention relates to a preparation method of macromolecular antibacterial microspheres. The method comprises the following steps: (1) weighing a total monomer and a rare earth metal Schiff base complex; wherein the total monomer is composed of a quaternary ammonium salt monomer, an acrylate monomer and methyl methacrylate; (2) uniformly mixing methyl methacrylate, a quaternary ammonium salt type monomer and an acrylate monomer, adding an oil-soluble initiator, and performing ultrasonic uniform mixing to obtain a mixed solution A; (3) slowly dropwise adding the mixed solution A into an ethanol aqueous solution for reaction while stirring at a constant speed to obtain a copolymer solution; (4) sequentially adding a dispersant aqueous solution, a styrene monomer, a rare earth metal Schiff base complex and an oil-soluble initiator into the copolymer solution, and ultrasonically mixing uniformly to obtain a mixed solution B; (5) stirring at a constant speed, slowly dropwise adding the mixed solution B into deionized water, and reacting to obtain a polymer antibacterial microsphere emulsion; and (6) performing centrifugal separation, washing and drying. The method is simple, efficient and safe, and the obtained antibacterial microspheres are green and environment-friendly.

Description

technical field [0001] The invention relates to the technical field of polymer antibacterial, in particular to a preparation method of polymer antibacterial microspheres. Background technique [0002] In the past few decades, infectious diseases caused by bacteria have been increasing, threatening the health of millions of people every year and becoming a public health issue of global concern. Bacterial infection refers to the infection caused by bacteria invading the human body, that is, pathogenic microorganisms such as bacteria, fungi, viruses, mycoplasma, chlamydia, and rickettsia invade the normal tissues of the human body, grow and reproduce in the body, cause inflammation of the human body, and even cause fatal diseases. . [0003] Antibacterial materials refer to a new class of functional materials that can kill or inhibit the growth and reproduction of microorganisms. They have extremely broad application prospects in the fields of medical care, household products,...

AI Technical Summary

Problems solved by technology

Quaternary ammonium salt is a typical representative of macromolecular antibacterial agent, for example: invention patent CN 110665374 A discloses a kind of preparation method of quaternary ammonium salt antibacterial material and the antibacterial material prepared thereof, and this material shows better antibacterial property, but alone Quaternary ammonium salt antibacterial materials are difficult to achieve high antibacterial effect; invention patent CN 111217956 A discloses a preparation method of cationic custard fruit-like acrylate copolymer antibacterial microspheres, and the prepared cationic custard fruit-like acrylate copolymer Antibacterial microspheres, which exhibit good antibacterial properties against both Escherichia coli and Staphylococcus aureus

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