Asymmetric polyethersulfone filter membrane for removing viruses, and preparation method thereof

Abstract

The invention provides an asymmetric polyethersulfone filter membrane for removing viruses, and a preparation method thereof. The filter membrane comprises a main body, one side surface of the main body is a first porous outer surface, the other side surface of the main body is a second porous outer surface, the average pore size of the first porous outer surface is 150-450 nm, and the pore area rate of the first porous outer surface is small and is 0.10-2%; the average pore size of the second porous outer surface is 10-40 nm, and the pore area of the second porous outer surface is 2.1-10%; the main body comprises a pre-filtering layer and a separation layer for intercepting viruses, one side of the pre-filtering layer is a first porous outer surface, and one side of the separation layer is a second porous outer surface; the other side of the pre-filtering layer and the other side of the separation layer are transited through continuous fibers; the polyethersulfone filter membrane is prepared only through a membrane casting solution, is integrally formed, does not need to be compounded, and is relatively simple in preparation process; meanwhile, the filter membrane has a relatively strong interception effect on parvoviruses with the particle size of 20 nm or more; and the filter membrane has high mechanical strength, is prone to processing and treating, and meets the requirements of practical application.

Description

technical field [0001] The invention relates to the technical field of membrane materials, in particular to an asymmetric polyethersulfone filter membrane for virus removal and a preparation method thereof. Background technique [0002] In recent years, in addition to plasma fractionation preparations derived from human blood, measures to improve virus safety are also required for biopharmaceuticals; therefore, drug manufacturers have conducted research on the introduction of virus removal / inactivation processes in the manufacturing process ; The method of removing virus by filtering with a filter membrane for removing virus is an effective method that can not denature useful proteins and can reduce viruses at the same time. [0003] In the field of plasma fractionation preparations, there are endless cases of human infection caused by parvovirus B19; in the field of biopharmaceuticals, there are also cases of contamination of Chinese hamster ovary (CHO, Chinese Hamster Ovar...

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Problems solved by technology

[0005] But this composite ultrafiltration membrane just can be made with at least two kinds of different casting membrane liquids, and its composite process is to use a slot die coating machine to cast two kinds of solutions (for example with attached Figure 11 ), the casting thickness of the first polymer solution is adjusted to a suitable thickness, the casting thickness of the second polymer solution is adjusted to a final layer thickness of 15 microns or about 10% of the overall film thickness, and the forming conditions are selected so that at 55 Before immersing in a water bath at ℃, the first solution is rapidly heated above the cloud point on the casting drum, while the second solution has not yet reached its cloud point; so that the first polymer solution forms a microporous layer, and the second polymer solution Form an ultrafiltration layer; the configuration of various casting solutions is relatively cumbersome, the composite process is complicated, and the economic cost is high, which limits the development of virus removal membranes to a certain extent

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