Polyhydroxy polymer microsphere as well as preparation method and application thereof

Abstract

The invention discloses a polyhydroxy polymer microsphere and a preparation method thereof, and the preparation method comprises the following steps: completely dissolving an acrylate substance and dithiothreitol in methanol, adding the solution into triethylamine, and conducting standing for a period of time at room temperature to obtain the polymer microsphere with uniform size. The method has the advantages that the used reagents and raw materials are common and easy to obtain, the reaction rate is high, the reaction conditions are mild, the operation method is simple, and the polyhydroxy polymer microsphere has wide application prospects in the field of adsorption.

Description

technical field [0001] The invention belongs to the field of polymer synthesis, and in particular relates to a polyhydroxy polymer microsphere and a preparation method thereof. Background technique [0002] Due to their high specific surface area, controllable size, easy functionalization, and high adsorption capacity, polymer microspheres have been widely used in the fields of ion adsorption, dye adsorption, drug release, biomedicine, and catalyst carriers. Generally, polymer polymer microspheres can be prepared by microfluidic method, suspension polymerization, dispersion polymerization, precipitation polymerization and other methods. Microfluidics is an emerging technology for the preparation of polymer microspheres. This method has advantages in controlling the composition, shape and particle size of polymer microspheres, but has the disadvantage of being difficult to prepare on a large scale; the suspension polymerization method is low-cost , easy to operate and large-...

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Problems solved by technology

Microfluidics is an emerging technology for the preparation of polymer microspheres. This method has advantages in controlling the composition, shape and particle size of polymer microspheres, but has the disadvantage of being difficult to prepare on a large scale; the suspension polymerization method is low-cost , easy to operate and large-scale production, but the prepared polymer microspheres have the disadvantage of wide particle size distribution; the polymer microspheres prepared by emulsion polymerization have the characteristics of high molecular weight and good monodispersity, but in the emulsion polymerization product system The emulsifier is not easy to remove, and it is easy to affect the performance of the product, thus limiting the application of the product, while the soap-free emulsion polymerization has no emulsifier residue, but the emulsion stability is poor, the solid content is low during the polymerization process, and large-scale production cannot be carried out Disadvantages; Dispersion polymerization has the advantages of simple, fast, and large-scale preparation of monodisperse, functionalized, and shape-controllable polymer polymer microspheres, but this method can only prepare polymer microspheres with a size between 500nm and 10μm. And it can't be used to prepare porous polymer polymer microspheres; precipitation polymerization becomes the main preparation method for preparing 1-10 μm monodisperse polymer microspheres because the system is simple and does not need any stabilizers and surfactants. Low bulk concentration, the need for a large amount of cross-linking agent and the limitation of toxic medium acetonitrile

[0003] The traditional precipitation polymerization uses two types of "star monomers" of styrene and acrylate as raw materials, and the solvent used is toxic acetonitrile, which is very environmentally unfriendly. In order to improve this shortcoming, subsequent researchers proposed distillation precipitation polymerization, through Use a distillation device to distill part of the solvent, and under the condition of no stirring, the polymer gradually precipitates from it and grows into polymer polymer microspheres. Although this makes the precipitation polymerization significantly improved, these reactions are in the form of free radical chains. It is well known that the free radical chain reaction conditions are relatively harsh, and it is easy to induce polymerization inhibition by oxygen, which will slow down the reaction rate and reduce the conversion rate. Usually, inert gas protection is required to prolong the reaction time during the polymerization process. Increase the amount of initiator to ensure the conversion rate of monomer and the final performance of polymer

This will cause the disadvantages of cumbersome operation, time-consuming and energy-consuming during the preparation of polymer microspheres.

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