Natural long-acting antibacterial and anti-inflammatory silk suture line and production method thereof
A suture, long-acting technology, applied in the direction of biochemical fiber treatment, braiding, coating, etc., can solve the problems of single drug loading, complex process, insignificant effect, etc., achieve good mechanical properties, and reduce the effect of infection
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Embodiment 1
[0030] This example proposes a natural long-acting antibacterial and anti-inflammatory silk suture and a preparation method thereof, wherein the antibacterial component of natural traditional Chinese medicine is berberine, and the natural traditional Chinese medicine component artemisinin is used as an anti-inflammatory component. The preparation method is:
[0031] (1) Degumming the silk before weaving to remove the sericin protein on the surface of the silk that is prone to inflammatory reactions in the human body due to the ash and impurities contained on the surface: put the accurately weighed silk into boiling at a concentration of 0.02mol / L of sodium carbonate (Na 2 CO 3 ) solution for degumming, take it out after 30 minutes, rinse with deionized water several times until the sericin is completely washed away, place it in a fume hood, and let it dry naturally.
[0032](2) A 16-64 spindle braiding machine is used to weave fibers with different proportions of shell and ...
Embodiment 2
[0040] This example shows a natural long-acting antibacterial and anti-inflammatory silk suture and its preparation method, wherein the natural antibacterial drug is chitin, and the natural long-acting anti-inflammatory drug is artemisinin, a traditional Chinese medicine component. The preparation method is:
[0041] (1) For the long-acting functional layer of the inner layer solution, the natural antibacterial drug chitin is used, and a chitin solution is provided. The solvent is deionized water with a concentration of 5-8 mg / mL, and artemisinin is dissolved in 40-80% (w / v) In polyethylene glycol 400, 600 or 800, the concentration is 4-7mg / mL, and combined with 5-8% silk fibroin solution, the mass ratio of silk fibroin to chitin to artemisinin solution is 10~2:1~8:1~8 is used as the inner layer core wire coating formula.
[0042] (2) For the functional layer of the outer layer solution, chitin is used, and chitin is dissolved in 1% acetic acid, hydrochloric acid or citric a...
Embodiment 3
[0047] This implementation case shows a natural long-acting antibacterial and anti-inflammatory silk suture and its preparation method, wherein the natural antibacterial drug is chitosan, and the natural anti-inflammatory component is artemisinin. For inner layer antibacterial and anti-inflammatory coating solution prescription is the chitosan of degree of deacetylation 60%, 75%, 80%, and the concentration of chitosan solution is 5-7mg / mL, and the concentration of silk fibroin solution is 5-8% ( w / v), in the present embodiment, regardless of the inner long-acting layer or the outer functional layer, a concentration of 30% glycerol (glycerol) was added, and magnetically stirred in a 60°C constant temperature water bath for 30-60 minutes, well mixed.
[0048] 8-64 spindle braiding machines are used to weave fibers with different shell-to-core wire ratios. Weaving parameters: gear ratio is 81 / 44 (44#), 81 / 28 (28#), 81 / 36 (36#) or a combination of several, the knitting speed is 6...
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