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Temperature-sensitive controlled-release nano pesticide vesicle as well as preparation method and application thereof

A nano-pesticide and vesicle technology, applied in the fields of botanical equipment and methods, applications, biocides, etc., can solve the problems of polluting food pesticides, residues, serious environmental problems, etc., to improve the effective utilization rate, suitable for industrial production, and cheap raw materials. easy-to-get effect

Pending Publication Date: 2022-04-01
江苏耘农化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional pesticide formulations have disadvantages such as high organic solvent content, dust drift and poor dispersibility, and the active ingredients will be lost during use due to droplet drift and rain washing.
In order to ensure the control effect, pesticides need to be sprayed many times, which not only increases the cost, but also causes serious environmental pollution and food pesticide residues

Method used

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  • Temperature-sensitive controlled-release nano pesticide vesicle as well as preparation method and application thereof
  • Temperature-sensitive controlled-release nano pesticide vesicle as well as preparation method and application thereof
  • Temperature-sensitive controlled-release nano pesticide vesicle as well as preparation method and application thereof

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preparation example Construction

[0021] The invention provides a method for preparing temperature-sensitive controlled-release nano-pesticide vesicles, comprising the following steps:

[0022] (1) Suzuki reaction occurs between bromotriphenylethylene and 4-hydroxyphenylboronic acid pinacol ester to obtain 4-(1,2,2-triphenylvinyl)phenol.

[0023] (2) Substituting the 4-(1,2,2-triphenylvinyl)phenol with acryloyl chloride to obtain 4-(1,2,2-triphenylvinyl)phenyl acrylate .

[0024] (3) The 4-(1,2,2-triphenylvinyl)phenyl acrylate and N-isopropylacrylamide undergo a reversible addition-fragmentation chain transfer polymerization reaction under the action of an initiator, A thermosensitive polymer is obtained.

[0025] (4) The temperature-sensitive polymer and thiamethoxam are self-assembled to prepare temperature-sensitive controlled-release nanopesticide vesicles.

[0026] In the invention, bromotriphenylethylene, 4-hydroxyphenylboronic acid pinacol ester and catalyst are mixed to undergo Suzuki reaction to ob...

Embodiment 1

[0037] The preparation method of 4-(1,2,2-triphenylvinyl)phenol is:

[0038] Into a 250 mL dry single-necked round bottom flask, bromotriphenylethylene (2.0 g), 4-hydroxyphenylboronic acid pinacol ester (1.4 g), tetrakis(triphenyl)phosphine palladium (0.5 g) and potassium carbonate were successively added (3.7g), after nitrogen replacement, 1,4-dioxane (90mL) and distilled water (30mL) were added in sequence. The round bottom flask was placed at 100°C for 16h. After the reaction was completed and cooled to room temperature, the reaction solution was extracted with ethyl acetate, washed three times with saturated aqueous sodium chloride solution, and the organic phase was collected. The organic phase was dried over anhydrous sodium sulfate, filtered, and ethyl acetate was distilled off under reduced pressure to obtain a crude product. The crude product was separated and purified through a silica gel column using petroleum ether and ethyl acetate (volume ratio 60:1) as the elu...

Embodiment 2

[0041] The preparation method of 4-(1,2,2-triphenylethenyl) phenyl acrylate is:

[0042] 4-(1,2,2-Triphenylethenyl)phenol (1 g) and dry dichloromethane (30 mL) were successively added into a dry 50 mL double-necked round bottom flask and fully dissolved. While stirring, the temperature of the reaction solution was lowered to 0°C. Subsequently, triethylamine (0.6 g) was added into the round bottom flask, and the temperature of the system was continued to be maintained at 0°C. Finally, acryloyl chloride (0.4 g) was slowly added dropwise into the round bottom flask, and reacted at 0° C. for 4 h. After the reaction is complete, a small amount of distilled water is added to the round bottom flask to quench unreacted acryloyl chloride. The resulting reaction solution was left standing to separate layers, washed 3 times with saturated sodium chloride solution, and the organic phase was collected. The organic phase was dried over anhydrous sodium sulfate, filtered, and dichlorometh...

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Abstract

The invention discloses a temperature-sensitive controlled-release nano-pesticide vesicle and a preparation method and application thereof, and belongs to the technical field of controlled-release nano-pesticides, and the preparation method of the temperature-sensitive controlled-release nano-pesticide vesicle comprises the following steps: carrying out Suzuki reaction on bromotriphenylethylene and 4-hydroxyphenylboronic acid pinacol ester to obtain the temperature-sensitive controlled-release nano-pesticide vesicle. The preparation method comprises the following steps: carrying out a substitution reaction on 4-(1, 2, 2-triphenylvinyl) phenol and acryloyl chloride to obtain 4-(1, 2, 2-triphenylvinyl) phenyl acrylate, carrying out a substitution reaction on 4-(1, 2, 2-triphenylvinyl) phenol and acryloyl chloride to obtain 4-(1, 2, 2-triphenylvinyl) phenyl acrylate, and carrying out a reaction on 4-(1, 2, 2-triphenylvinyl) phenyl acrylate and N-isopropylacrylamide to obtain 4-(1, 2, 2-triphenylvinyl) phenyl acrylate. The temperature-sensitive controlled-release nano-pesticide vesicle is prepared by taking thiamethoxam as a raw material and carrying out reversible addition fragmentation chain transfer polymerization reaction under the action of an initiator, the temperature-sensitive polymer is obtained, the temperature-sensitive controlled-release nano-pesticide vesicle is prepared from the temperature-sensitive polymer and thiamethoxam through self-assembly, and the nano-pesticide vesicle shows strong temperature controlled-release performance and ideal insecticidal rate.

Description

technical field [0001] The invention belongs to the technical field of slow-release nano-pesticides, and in particular relates to a temperature-sensitive controlled-release nano-pesticide vesicle and its preparation method and application. Background technique [0002] Pesticides are an important material basis for preventing major biological disasters and promoting the sustainable and stable growth of agricultural products. However, traditional pesticide formulations have disadvantages such as high content of organic solvents, dust drift and poor dispersibility. During use, active ingredients will be lost due to droplet drift and rain washing. In order to ensure the control effect, pesticides need to be sprayed many times, which not only increases the cost, but also causes serious environmental pollution and food pesticide residues. Improving the utilization rate of pesticides and reducing the amount of pesticides used is an urgent problem to be solved at present. Improvi...

Claims

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Application Information

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IPC IPC(8): A01N25/26A01N51/00A01P7/04C08F220/54C08F212/32
CPCY02A50/30
Inventor 刘睿张清朱森强潘倩倩陈蕾冰崔妍李楠罗志会刘慕兰
Owner 江苏耘农化工有限公司
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