Preparation and application of soluble polymer microneedle for enhancing light transparency of skin

A polymer and soluble technology, applied in the measurement of color/spectral characteristics, fluorescence/phosphorescence, scattering characteristics, etc., can solve the problems of limiting the application range of optical imaging technology, complicated operation of physical methods, and toxic and side effects of human body, etc. Transparency, non-toxic and side effects, and low-cost effects

Pending Publication Date: 2022-04-12
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the light-transparency effect of the light-transparent agent on the skin has been improved after a variety of physical and chemical means are assisted in administration, the physical methods currently used are complex to operate, cumbersome to implement, and even cause light or heavy mechanical damage to the body. ; Some penetration enhancers have certain toxic and side effects on the human body
In this way, the scope of application of optical imaging technology is limited. Therefore, it is urgent to find a safe, convenient and efficient way of administering light-transparent agents.

Method used

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  • Preparation and application of soluble polymer microneedle for enhancing light transparency of skin
  • Preparation and application of soluble polymer microneedle for enhancing light transparency of skin
  • Preparation and application of soluble polymer microneedle for enhancing light transparency of skin

Examples

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preparation example Construction

[0037] Another embodiment of the present invention provides a method for preparing a soluble polymer microneedle for enhancing skin light transparency, the method comprising: containing one or more of hydroxyl, amido, carboxyl, amino Dissolving the soluble polymer into a solvent to obtain a polymer solution, pouring the polymer solution onto a microneedle mold, removing air bubbles in a vacuum, drying and peeling off, to obtain the soluble polymer microneedle.

[0038] Wherein, the mass fraction of the soluble polymer in the polymer solution is 1%-70%. The solvent is one or more of deionized water, ethanol, ethylene glycol, propanol, acetic acid, acetone, and anhydrous dichloromethane.

[0039] Yet another embodiment of the present invention provides a method for preparing a soluble polymer microneedle for enhancing skin light transparency. The method further includes adding one or more The soluble polymer and optical transparent agent are dissolved in a solvent to obtain a p...

Embodiment 1

[0044] This example provides a method for preparing a soluble polymer microneedle. see figure 1 , the method includes the following steps:

[0045] (1) Mix the PDMS prepolymer and the curing agent at a ratio of 10:1w / w, stir well, then vacuumize, and put it in a vacuum oven at 80°C for 2 hours to obtain a PDMS die. Then the laser beam is drilled on the flat and hardened 1cm×1cm PDMS module to form a series of neatly arranged tapered holes. The depth of the holes is 300 μm. Thus, four PDMS microneedle molds with different numbers of holes were obtained.

[0046] (2) Add 100 mg of hyaluronic acid (20-40 kDa) powder gradually into 1000 μL of deionized water, stir well, and prepare a uniform polymer solution. Pour the prepared solution into 4 PDMS microneedle molds with different numbers of holes, and then put it into a vacuum drying oven and use 85KPa to evacuate for 10min twice to remove air bubbles and allow the solution to better enter the PDMS mold. in the pores. After ...

Embodiment 2

[0053] This example provides a method for preparing a soluble polymer microneedle. The method includes the following steps:

[0054] (1) Mix the PDMS prepolymer and the curing agent at a ratio of 10:1w / w, stir well, then vacuumize, and put it in a vacuum oven at 80°C for 2 hours to obtain a PDMS die. Then the laser beam is drilled on the flat and hardened 1cm×1cm PDMS module to form a series of neatly arranged tapered holes. The depth of the holes is 300 μm. Thus, four PDMS microneedle molds with different numbers of holes were obtained.

[0055] (2) Add 0.9 mg of dextran (50-70 kDa) and 89.1 mg of polyvinyl alcohol (100-110 kDa) gradually into 210 μL of deionized water, stir on a magnetic stirrer and heat to boiling to obtain a polymer mixed solution. After cooling to room temperature, pour the prepared solution into 4 PDMS microneedle molds with different numbers of holes, and then put it into a vacuum drying oven and use 85KPa to evacuate for 10min twice to remove air bu...

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Abstract

The invention discloses preparation and application of a soluble polymer microneedle for enhancing light transparency of skin. The soluble polymer microneedle comprises a soluble polymer with a light transparent effect, or the microneedle comprises the soluble polymer with the light transparent effect and a light transparent agent, and functional groups of the soluble polymer comprise one or more of hydroxyl, acylamino, carboxyl and amino. The optical clearing agent comprises mannitol, sorbitol, xylitol, fructose, cane sugar, maltose, trehalose or cellobiose. The soluble polymer microneedle disclosed by the invention can painlessly, safely and effectively break through the barrier effect of cuticle and directly act on dermis, so that the refractive index in the skin is quickly homogenized, and the skin tissue becomes transparent to light. The problem that in the prior art, the light transparent agent is in a solution state and can only be delivered in the modes of injection, smearing and the like, and the light transparent effect is poor is solved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and more specifically relates to the preparation and application of soluble polymer microneedles for enhancing skin light transparency. Background technique [0002] Optical imaging technology can be well applied to screening, diagnosis and monitoring of diseases due to its non-invasive, high-resolution and high-contrast characteristics. However, the turbid nature of the skin itself limits the penetration depth of light in tissues, making these techniques only able to image superficial tissues with low image contrast. Biological tissue light-transparency technology has brought new ideas to solve this problem. It introduces light-transparency agents into tissues to temporarily increase the matching degree of refractive index between tangible and invisible media in tissues, thereby reducing tissue Light scattering makes biological tissue "transparent", so as to achieve the purpose of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/27G01N21/84G01N21/64G01N21/55G01N15/14
Inventor 朱锦涛欧阳梦萍张连斌陶娟王雪李延
Owner HUAZHONG UNIV OF SCI & TECH
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