Fluorine-containing copolymer antibacterial hemostatic material, preparation method and application thereof, and sanitary material

A technology of hemostatic material and copolymer, applied in application, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor application performance of hemostatic material, reduce blood loss and bacterial adhesion, excellent antibacterial properties, and excellent clot self-separation performance. Effect

Pending Publication Date: 2022-05-13
UNIV OF JINAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can effectively solve technical problems such as poor application performance of existing hemostatic materials

Method used

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  • Fluorine-containing copolymer antibacterial hemostatic material, preparation method and application thereof, and sanitary material
  • Fluorine-containing copolymer antibacterial hemostatic material, preparation method and application thereof, and sanitary material
  • Fluorine-containing copolymer antibacterial hemostatic material, preparation method and application thereof, and sanitary material

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preparation example Construction

[0037] The invention provides a preparation method of a fluorine-containing copolymer antibacterial and hemostatic material, comprising the following steps:

[0038] S1. Under a protective gas, react the fluorine-containing acrylic monomer, the acrylic monomer and the initiator, and after the reaction, wash to obtain the fluorine-containing acrylic copolymer;

[0039] S2, reacting the fluorine-containing acrylic copolymer and the cross-linking agent, and drying to obtain a cross-linked fluorine-containing acrylic copolymer after the reaction;

[0040] S3. Add the cross-linked fluorine-containing acrylic copolymer into the antibacterial agent solution to react, and after the reaction, obtain the fluorine-containing copolymer antibacterial and hemostatic material through dialysis.

[0041] In the present invention, the fluorine-containing acrylate monomer is perfluoroalkyl acrylate, and the general formula of the perfluoroalkyl acrylate is CH 2 =CRCOO(CH 2 ) m C n f 2n+1 , ...

Embodiment 1

[0062] Dissolve 2-perfluorodecyl ethyl acrylate (PFDA), methacrylic acid and azobisisobutyronitrile at a molar ratio of 1:20:0.125 in tetrahydrofuran (the mass-volume ratio of 2-perfluorodecyl ethyl acrylate to tetrahydrofuran 1g: 17mL) and then added to the three-neck flask, under N 2 Under protection, heat up to 65°C, keep warm for 8 hours, and wash with n-hexane precipitation three times to obtain a fluorine-containing acrylic copolymer; then dissolve the fluorine-containing acrylic copolymer with ultrapure water, and add the carboxyl molar ratio to the acrylic monomer to be 0.05: 1 aziridine, stirred for 1 hour, put the solution in a dialysis bag to remove excess cross-linking agent, and dried the solution in a vacuum oven (65° C.) for 24 hours to obtain a cross-linked fluorine-containing acrylic copolymer; The cross-linked fluorine-containing acrylic copolymer dispersed in pure water was added to the mixed solution of polyhexanide hydrochloride (PHMB 20% solution) and amm...

Embodiment 2

[0069] Dissolve dodecafluoroheptyl methacrylate, acrylic acid and azobisisobutyronitrile at a molar ratio of 1:40:0.15 in tetrahydrofuran (the mass volume ratio of dodecafluoroheptyl methacrylate to tetrahydrofuran is 1g:18mL) and add to the three-necked bottle, in N 2 Under protection, raise the temperature to 75°C, keep it warm for 10 hours, and wash it four times with n-hexane precipitation to obtain the fluorine-containing acrylic copolymer; then dissolve the fluorine-containing acrylic copolymer with ultrapure water, and add the carboxyl molar ratio to the acrylic monomer to be 0.08 : 1 aziridine, after stirring for 1 hour, the solution was placed in a dialysis bag to remove excess cross-linking agent, and the solution was dried in a vacuum oven (70° C.) for 32 hours to obtain a cross-linked fluorine-containing acrylic copolymer; The cross-linked fluorine-containing acrylic copolymer dispersed in pure water was added to the mixed solution of polyhexanide hydrochloride (PH...

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Abstract

The invention belongs to the technical field of polymer hemostatic materials, and discloses a fluorine-containing copolymer antibacterial hemostatic material and a preparation method thereof.The method comprises the following steps that S1, under protective gas, fluorine-containing acrylate monomers, acrylic monomers, an initiator and a solvent are mixed for a reaction, and after the reaction is finished, a reaction product is obtained; washing to obtain a fluorine-containing acrylic copolymer; s2, reacting the fluorine-containing acrylic copolymer with a cross-linking agent, and after the reaction is finished, drying to obtain a cross-linked fluorine-containing acrylic copolymer; and S3, adding the cross-linked fluorine-containing acrylic copolymer into the antibacterial agent solution to react, and after the reaction is finished, dialyzing to obtain the fluorine-containing copolymer antibacterial hemostatic material. The method is simple and easy to regulate and control, the prepared antibacterial hemostatic material can be prepared into a coating on the surface of gauze or suture lines, and the coating has excellent hemostatic performance and bactericidal activity and has good application prospects in the aspects of biology, medicine, sanitation and the like.

Description

technical field [0001] The invention relates to the technical field of polymer hemostatic materials, in particular to a fluorine-containing copolymer antibacterial hemostatic material, its preparation method and application, and a hygienic material. Background technique [0002] In addition to bacterial infection, medical devices, especially wound dressings, should also pay attention to hemostasis, especially uncontrollable bleeding is the main cause of death in the clinical field. When the human body encounters natural disasters or accidents, uncontrolled excessive blood loss and insufficient hemostasis are important causes of death. According to different statistics, about 30% of deaths are caused by excessive blood loss when the body is seriously injured. Therefore, adequate hemostasis is the basic strategy to prevent bleeding to avoid death, and it is also the first step in wound healing. The final directions and goals of wound dressing research are as follows: (1) good...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04A61L24/06A61L15/18A61L15/24A61L15/26A61L15/46C08F220/06C08F220/24
CPCA61L24/06A61L24/046A61L24/0015A61L15/26A61L15/24A61L15/18A61L15/46C08F220/06A61L2300/10A61L2300/206A61L2300/404A61L2400/04C08F220/24C08L33/02C08L79/00
Inventor 李学安晓燕张玉福丁继元张硕李文婷
Owner UNIV OF JINAN
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