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Compound amino acid injection and preparation method thereof

A compound amino acid and injection technology, applied in the field of biomedicine, can solve the problems of poor solution stability and slow release effect, and achieve the effects of improving the utilization rate and reducing the number of injections

Pending Publication Date: 2022-07-22
天津金耀集团湖北天药药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solve the problems of poor sustained release effect and poor solution stability in the existing compound amino acid injection

Method used

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  • Compound amino acid injection and preparation method thereof
  • Compound amino acid injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A compound amino acid injection, in parts by weight, comprising the following components: 1 part of lysine acetate, 0.5 part of methionine, 0.5 part of phenylalanine, 0.2 part of threonine, 0.4 part of alanine, 0.4 part of arginine, 0.03 part of aspartic acid, 0.07 part of glutamic acid, 0.7 part of histidine, 0.6 part of proline, 0.3 part of serine, 0.15 part of tyrosine, 0.5 part of glycine, 0.07 part of cysteine parts, 180 parts of water for injection, and 5 parts of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt complex containing isoleucine, leucine, tryptophan and valine.

[0033]The preparation method of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt compound comprising isoleucine, leucine, tryptophan and valine is as follows:

[0034] Wherein, the mass ratio of isoleucine, leucine, tryptophan, valine, polylactic acid, modified Qianhu and chitosan quaternary ammonium salt in the complex is 0.5:1:0.05:0.5 :3:5:4.

...

Embodiment 2

[0043] A compound amino acid injection, in parts by weight, comprising the following components: 1.5 parts of lysine acetate, 1.0 parts of methionine, 1.0 parts of phenylalanine, 0.6 parts of threonine, 0.6 parts of alanine, 0.6 part of arginine, 0.05 part of aspartic acid, 0.05 part of glutamic acid, 0.5 part of histidine, 0.4 part of proline, 0.2 part of serine, 0.1 part of tyrosine, 0.3 part of glycine, 0.04 part of cysteine parts, 200 parts of water for injection, and 7 parts of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt complex containing isoleucine, leucine, tryptophan, and valine.

[0044] The preparation method of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt compound comprising isoleucine, leucine, tryptophan and valine is as follows:

[0045] Wherein, the mass ratio of isoleucine, leucine, tryptophan, valine, polylactic acid, modified Qianhu and chitosan quaternary ammonium salt in the complex is 0.7:1.2:0.08:0.7 ...

Embodiment 3

[0054] A compound amino acid injection, in parts by weight, comprising the following components: 2 parts of lysine acetate, 1.5 parts of methionine, 1.5 parts of phenylalanine, 1.0 parts of threonine, 0.8 parts of alanine, 0.8 part of arginine, 0.07 part of aspartic acid, 0.03 part of glutamic acid, 0.3 part of histidine, 0.2 part of proline, 0.1 part of serine, 0.05 part of tyrosine, 0.1 part of glycine, 0.03 part of cysteine parts, 220 parts of water for injection, and 10 parts of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt complex containing isoleucine, leucine, tryptophan, and valine.

[0055] The preparation method of the polylactic acid-modified fronthu-chitosan quaternary ammonium salt compound comprising isoleucine, leucine, tryptophan and valine is as follows:

[0056] Wherein, the mass ratio of isoleucine, leucine, tryptophan, valine, polylactic acid, modified Qianhu and chitosan quaternary ammonium salt in the complex is 1:1.5:0.1:0.8 :5:...

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Abstract

The invention discloses a compound amino acid injection and a preparation method of the compound amino acid injection. The compound amino acid injection is prepared from the following components in parts by weight: 1 to 2 parts of lysine acetate, 0.5 to 1.5 parts of methionine, 0.5 to 1.5 parts of phenylalanine, 0.2 to 1.0 part of threonine, 0.4 to 0.8 part of alanine, 0.4 to 0.8 part of arginine, 0.03 to 0.07 part of aspartic acid, 0.03 to 0.07 part of glutamic acid, 0.3 to 0.7 part of histidine, 0.2 to 0.6 part of proline, 0.1 to 0.3 part of serine, 0.05 to 0.15 part of tyrosine, 0.1 to 0.5 part of glycine, 0.03 to 0.07 part of cysteine, 180 to 220 parts of water for injection, and a solution containing isoleucine, leucine and tryptophan, 5 to 10 parts of a polylactic acid-modified radix peucedani-chitosan quaternary ammonium salt compound of valine; according to the invention, the prepared compound amino acid injection has a certain slow release capability, and when the compound amino acid injection is applied, part of amino acids can be slowly released, so that the injection frequency is reduced, and the utilization rate of the amino acids is improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to a compound amino acid injection and a preparation method thereof. Background technique [0002] Amino acids are important nutrients for the human body. When patients cannot ingest protein from food orally and cause malnutrition, they have to use parenteral routes to supply nitrogen sources of protein to maintain the necessary amino acid nutrition for the human body. Amino acid infusion is a hospital One of the commonly used infusions. Compound amino acid injection is currently clinically used for: (1) increased protein consumption caused by surgery, trauma, fractures and burns; (2) tissue protein synthesis and utilization disorder caused by liver disease; (3) gastrointestinal dysfunction (4) abnormal urinary nitrogen caused by polyuria and renal disease; (5) increased protein demand caused by hyperthyroidism, fever and wasting diseases; (6) low protein demand caus...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4172A61K36/23A61K47/61A61P3/02A61K9/107A61K47/34A61K31/198A61K31/401
CPCA61K31/198A61K31/4172A61K31/401A61K9/0019A61K9/08A61K36/23A61K47/61A61P3/02A61K9/1075A61K47/34
Inventor 曹琦
Owner 天津金耀集团湖北天药药业股份有限公司
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