Green synthesis process of betaine hydrochloride

A green synthesis, hydrochloride technology, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of complex separation process, environmental pollution, environmental pollution, etc., achieve short process flow and lower reaction temperature , the effect of shortening the reaction time

Inactive Publication Date: 2002-10-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the betaine as a feed additive is a natural substance extracted from sugar beet waste honey by ion exchange method or ion exclusion method; although the extraction method has raw materials that are cheap and easy to obtain, it is limited by seasons and regions, and separation The process is complicated, the energy consumption is high, and the environment is polluted; in recent years, the production technology of betaine or betaine hydrochloride has developed from extraction to chemical synthesis, and its products have been put into industrial production
The chemical synthesis method generally uses sodium chloroacetate and trimethylamine as raw materials, re...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] At room temperature, put calcium chloroacetate into a reaction flask equipped with a stirring and reflux condenser, add water at a weight ratio of 3.5 times, and slowly add 30% trimethylamine dropwise at a molar ratio of calcium chloroacetate to trimethylamine of 1:2.2 Aqueous solution, the temperature of the control system does not exceed 40°C. After the feeding is completed, keep it warm at 40°C for 1.5 hours; the reaction solution is acidified with sulfuric acid to make the pH = 1, until there is no white precipitate, filter, and the filter cake is dried to obtain the by-product calcium sulfate ; The filtrate was evaporated and concentrated until a large number of solid crystals were precipitated, and dried under normal pressure at 100 ° C to obtain betaine hydrochloride.

Embodiment 2

[0017] At room temperature, put chloroacetic acid into a reaction flask equipped with stirring and reflux condenser, add 4.5 times the weight ratio of water to dissolve, put into calcium hydroxide for neutralization according to the molar ratio of chloroacetic acid and calcium hydroxide at 2:1.05, and then press The molar ratio of chloroacetic acid and trimethylamine is 1: 2.0 and slowly add 30% trimethylamine aqueous solution dropwise, and the temperature of the control system does not exceed 40°C. After the addition is completed, it is kept at 40°C for 3 hours; the reaction solution is acidified with sulfuric acid to make pH = 1.5, until there is no white precipitate, filter, and dry the filter cake to obtain calcium sulfate as a by-product; the filtrate is evaporated and concentrated until a large amount of solid crystals are precipitated, and then vacuum-dried to obtain betaine hydrochloride.

Embodiment 3

[0019] At room temperature, put chloroacetic acid into a reaction flask equipped with stirring and reflux condenser, add water with a weight ratio of 4.5 times, and put in calcium carbonate for neutralization according to the molar ratio of chloroacetic acid and calcium carbonate at 2:11, then press chloroacetic acid and calcium carbonate The molar ratio of trimethylamine is 1:2.1, slowly add 30% trimethylamine aqueous solution dropwise, and the temperature of the control system does not exceed 40°C. After the addition is completed, keep the temperature at 40°C for 2 hours; the reaction solution is acidified with sulfuric acid to make pH=1.0 , until there is no white precipitate, filter, and dry the filter cake to obtain the by-product calcium sulfate; the filtrate is evaporated and concentrated until a large amount of solid crystals are precipitated, and dried under normal pressure at 105°C to obtain betaine hydrochloride. Example 4

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Abstract

The green synthesis process of betaine hydrochloride incldues the steps of; chemical reaction of calcium chlorocetate and water solution of trimethylamine in certain temperature inside a reactor bottle; separation and purification including acidifying the reacted liquid with sulfuric acid or phosphoric acid, filtering and drying filter cake to obtain calcium sulfate or calcium phosphate as side product; and concentration and crystallization of the filtrate and drying. The said technological process is short, and has mild conditions, low power consumption and good separation effect and can produce betaine hydrochloride with 98.5% over purity in the yield over 96%.

Description

technical field [0001] The invention relates to a green synthesis method of betaine hydrochloride. Background technique [0002] Betaine widely exists in animals and plants, and its basic function as a feed additive is as a methyl donor for animals, which can replace methionine and choline chloride, and can promote animal growth and improve feed conversion efficiency. Secondly, betaine is a new type of nutrient redistribution agent for livestock and poultry. Adding betaine in the diet can increase the carcass lean meat percentage, reduce the backfat thickness of fattening pigs, improve the quality and flavor of meat products, and increase the myoglobin, Intramuscular fat and inosinic acid content, which is of great significance for improving the color, aroma and taste of meat. Betaine has been widely used as a feed additive in the aquaculture industry. At present, the commercial betaine at home and abroad is mainly supplied in the form of betain...

Claims

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Application Information

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IPC IPC(8): C07C227/14C07C227/18C07C229/06C07C229/12
Inventor 许梓荣夏枚生胡彩虹
Owner ZHEJIANG UNIV
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