Carboxymethyl chitosan potassium zinc bismuth and preparation process and application thereof

A technology of carboxymethyl chitosan bismuth and chitosan, applied in the field of carboxymethyl chitosan bismuth zinc potassium, can solve the problem that the erosion effect is not as good as that of biological macromolecules, achieve good market application prospects, and reduce the risk of drunkenness Possibility, effect of promoting self-repair and healing

Inactive Publication Date: 2005-06-08
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sucralfate can combine with pepsin in the stomach, inhibit pepsin from decomposing gastric wall protein, and can be combined with mucin secreted by gastric mucosa and has a certain anti-acid effect, so it is widely used in clinic; , Nitrogen has a high affinity, has a strong binding ability to metallothionein, mucosal glycoproteins, enzymes and peptides, and can effectively inhibit the growth of Helicobacter pylori. It is a kind of mucosal protection with good development prospects. At present, the widely used ones mainly include colloidal basic bismuth citrate, bismuth subnitrate, etc.; prostaglandin derivatives have a certain protective effect on cells, and can also increase the blood flow of gastric mucosa and the content of mucopolysaccharides, and promote Ulcer surface healing, etc.; but these are mostly low-molecular-weight substances, which are inferior to biological macromolecular substances in terms of film-forming strength and isolation of gastric acid and pepsin erosion

Method used

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  • Carboxymethyl chitosan potassium zinc bismuth and preparation process and application thereof
  • Carboxymethyl chitosan potassium zinc bismuth and preparation process and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take by weighing 5g chitosan (deacetylation degree DD=75%), be dissolved in the aqueous solution of the formic acid of 500mL1% (mass percentage concentration, the same below), filter out the insoluble matter, slowly add dropwise the Zinc chloride aqueous solution 80ml, after stirring at room temperature for 2 hours, adjust the pH to 6.0 with dilute ammonia water, continue the reaction for 2 hours, precipitate with ethanol, wash, dehydrate, and then vacuum-dry to obtain a white solid of chitosan-zinc complex. Weigh 5g of the solid into the reactor, add 40mL12moL·L -1 Potassium hydroxide aqueous solution and 50mL ethanol were swelled overnight, then 12g chloroacetic acid was dissolved in 10mL ethanol and slowly added dropwise, after the dropwise addition was completed, the reaction was kept at 55°C for 4 hours, after filtration, washed repeatedly with 70% ethanol aqueous solution, and then washed with Dehydration with water and ethanol, and vacuum drying to obtain zinc po...

Embodiment 2

[0015] Weigh 5g of chitosan (deacetylation degree DD=87%), dissolve in 500mL of 1% formic acid aqueous solution, filter out the insoluble matter, slowly add 100ml of zinc sulfate aqueous solution containing 2g of zinc dropwise under stirring, and react for 3h under stirring at room temperature Finally, adjust the pH to 6.0 with dilute KOH aqueous solution, continue the reaction for 3 hours, precipitate with acetone, wash, dehydrate, and then vacuum-dry to obtain a white solid of chitosan-zinc complex. Weigh 5g of the solid into the reactor, add 50mL 10moL·L -1 Potassium hydroxide aqueous solution and 50mL isopropanol were swelled overnight, then 14g chloroacetic acid was dissolved in 10mL isopropanol and slowly added dropwise, after the dropwise addition was completed, the reaction was kept at 65°C for 2.5h, and after filtration, repeated with 70% ethanol aqueous solution Washing, dehydration with acetone, and vacuum drying to obtain zinc potassium carboxymethyl chitosan. Wei...

Embodiment 3

[0017] Weigh 5g of chitosan (deacetylation degree DD=96%), dissolve in 500mL of 1% formic acid solution, filter out the insoluble matter, slowly add 60ml of zinc acetate aqueous solution containing 1g of zinc dropwise under stirring, and react for 2h under stirring at room temperature Finally, adjust the pH to 6.0 with dilute KOH aqueous solution, continue the reaction for 3 h, precipitate with acetone, wash, dehydrate, and then vacuum-dry to obtain a white solid of chitosan-zinc complex. Weigh 5g of the solid into the reactor, add 60mL 12moL·L -1 Potassium hydroxide aqueous solution and 50mL isopropanol were swelled overnight, then 16g of chloroacetic acid was dissolved in 10mL isopropanol and slowly added dropwise, after the dropwise addition was completed, the reaction was kept at 60°C for 3h, and after filtration, it was washed repeatedly with 70% ethanol aqueous solution , and then dehydrated with acetone, and vacuum-dried to obtain carboxymethyl chitosan zinc potassium. ...

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Abstract

A compound, carboxymethylchitasan bismuth zink potassium [(C12H16O8N2R2Zn)m(C12H20O8N2R2)n], for treating digestive ulcer, protecting mucosa of stomach and sobering-up is prepared through reaction between chitosan and Zn, carboxymethylation reaction, reacting on potassium hydroxide and bismuth salt, depositing, washing, filtering, baking and pulverizing.

Description

technical field [0001] The invention relates to a carboxymethyl chitosan bismuth zinc potassium, in particular to a carboxymethyl chitosan bismuth zinc potassium and its preparation method and application in gastrointestinal mucosa protection and peptic ulcer resistance. Background technique [0002] Gastrointestinal diseases, including chronic gastritis, functional dyspepsia, peptic ulcer and gastric cancer, are among the most common diseases in the world. According to the "World Cancer Report" published by the World Health Organization, there are about 870,000 new gastric cancer patients and 940,000 bowel cancer patients each year. Among various gastrointestinal diseases, peptic ulcer is seriously affecting the quality of life of modern people because of its long course, periodic attacks and rhythmic pain. At present, the clinically used anti-peptic ulcer drugs mainly include antacids, gastric acid secretion inhibitors, and ulcer surface mucosal protection drugs. Antacid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722C08B37/08
Inventor 赵峡于广利杨桂华
Owner OCEAN UNIV OF CHINA
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