Application of astragaloside in medicine for treating or preventing insulin resistance

An insulin resistance and astragalus polysaccharide technology, applied in the field of medical medicine, can solve the problems of hypoglycemia, weight gain, pancreatic islet cell failure, pancreatic islet cell failure, etc., and achieve the effects of lowering blood sugar, lowering the insulin resistance index, and improving abnormal glucose tolerance.

Inactive Publication Date: 2006-03-29
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Application prospects and disadvantages: Compared with sulfonylureas, metformin has relatively mild hypoglycemic effect and less hypoglycemia
[0018] Application prospects and disadvantages: the effect of inhibiting α-glucosidase is reversible, so the conversion to glucose is only delayed, not completely blocked
[0023] Application prospects and disadvantages: the price paid by early products because they can only stimulate insulin secretion is that the pancreatic beta cells are "overworked", which will eventually lead to the failure of pancreatic islet cells! This kind of counterproductive treatment concept ignores the negative effects of long-term stimulation of sick islet cells, which will lead to premature failure of islet cell function and early complications, which will cause irreparable life costs
[0025] Application prospects and disadvantages: Because the mechanism of action is the same as the previous one, both of which are to promote the secretion of insulin by pancreatic β cells, so it also has the aforementioned side effects
[0028] Application prospects and disadvantages: This class of drugs can cause hypoglycemia and weight gain

Method used

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  • Application of astragaloside in medicine for treating or preventing insulin resistance
  • Application of astragaloside in medicine for treating or preventing insulin resistance
  • Application of astragaloside in medicine for treating or preventing insulin resistance

Examples

Experimental program
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Effect test

preparation example Construction

[0100] Preparation of astragalus polysaccharide tablets: weigh 30% of astragalus polysaccharide powder, 45% to 50% of sodium lauryl sulfate (pulled into slurry) and 12% carboxymethyl starch according to the weight ratio (unit gram). (pulled into pulp), magnesium stearate 3000 per 100,000 tablets

[0101] Specific preparation method: mix and stir astragalus polysaccharide powder, sodium lauryl sulfate and carboxymethyl starch evenly to make a soft material. The wetting agent can also be 50% ethanol, sieve, dry (at a temperature of about 90°C), and finally add Magnesium stearate is mixed evenly, and pressed into tablets, the weight of the tablet is about 0.6 g.

[0102] Preparation of astragalus polysaccharide powder: weigh astragalus polysaccharide powder 1.0, xylose 0.1, carboxymethyl starch 0.8, acacia gum 0.2, protein Q.S., 3.5% glyceryl monostearate Q.S.

[0103]Specific preparation method: Astragalus polysaccharide powder is mixed with xylose, carboxymethyl starch, gum ar...

Embodiment 1

[0108] Example 1 Astragalus polysaccharide as the preparation of APS for the treatment of alloxan (alloxan) induced type 1 diabetic rat medicine

[0109] 30 SD rats, male or female, body weight 221.4±16.98g, were randomly divided into three groups, 10 rats in each group: (1) normal control group (control) (2) diabetic group (DM), alloxan 200mg / kg intraperitoneally Injection, 72 hours after injection, if the predicted blood sugar is above 11.1 mmol, the modeling is successful. Daily intraperitoneal injection of normal saline. (3) Astragalus polysaccharide treatment group (APS), after successful modeling with alloxan, received intraperitoneal injection of APS injection 400 mg / kg daily for five consecutive weeks. The above three groups were given a high-sugar and high-fat diet every day.

[0110] Observe the spirit, hair, activity, body weight, diet, etc. of the rats. Tail vein blood was collected after 2 weeks and 5 weeks of treatment, and blood glucose was measured with a on...

Embodiment 2

[0114] Example 2 Astragalus polysaccharide as a preparation treatment of APS on high-sugar and high-fat diet plus small doses of streptozotocin (streptozotocin, STZ) induced insulin resistance and type 2 diabetes medicine (model) and as a weight-loss drug application

[0115] High-fat diet (high-fat diet, HFD) (41% fat, 41% carbohydrate and 18% protein). Streptozotocin (STZ) (30 mg / kg, dissolved in 0.1 mol / L citrate buffered saline, pH 4.5) or an equal volume of citrate buffered saline. After the injection, the animals had free access to food and water and maintained a high-fat diet. 72 hours after STZ injection, the fasting blood glucose of the animals was measured, and those greater than 6.7mmol / L could be diagnosed as diabetes. APS treatment can significantly reduce the body weight of HFD / STZ diabetic rats (Pfigure 1 .

[0116] control group

[0117] * P<0.05 vs control group, eP<0.05 vs TIIDM group

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Abstract

An application of astragalus polyose in preparing the medicines for preventing and treating the insulin resistant diseases, such as diabetes, obesity, diabetic hematangionosus, diabetic hepatism, etc, is disclosed.

Description

technical field [0001] The present invention relates to medical medicine, and more specifically relates to the use in a medicine for preventing and treating insulin resistance, which is suitable for the treatment or prevention of diabetes and its vascular disease, diabetic liver disease, kidney disease and coronary artery disease. Background technique [0002] Insulin resistance is the common soil of diseases such as diabetes, atherosclerosis and hypertension, and is a common and frequently-occurring disease that seriously endangers human health. If insulin resistance is not treated and prevented early, it will develop into type 2 diabetes, coronary atherosclerosis, hypertension and other diseases. Especially striking is type 2 diabetes, which accounts for about 90%-95% of the total number of diabetic patients. Type 2 diabetes is becoming a very common chronic disease due to the increase in the elderly population, obesity and lack of exercise and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10A61P3/04A61P1/16A61P9/00A61P13/12
Inventor 欧阳静萍吴勇王保华吴珂李柯毛先晴
Owner WUHAN UNIV
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