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Medical material with heterogeneous coating and its preparing method

A non-homogeneous coating technology, which is applied in the fields of pharmaceutical formulation, medical science, dental preparations, etc., can solve the problems of long-term coating decline, high solubility, and insufficient activity, etc., to ensure long-term stability and bonding strength High, mineralization-promoting effect

Inactive Publication Date: 2006-05-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are several significant shortcomings in the hydroxyapatite coating: first, its solubility is relatively large, which will cause the long-term effectiveness of the coating to decrease
Secondly, its activity is still not strong enough to promote the interaction between implants and human tissues, so as to accelerate the regeneration of new bone and the rapid integration of materials and bone tissue.
At the same time, the preparation method plays a very important role in the performance of the coating. For example, the high temperature of the plasma sprayed coating causes the decomposition of hydroxyapatite during the preparation process, which makes the long-term performance of the coating more and more reduced.

Method used

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  • Medical material with heterogeneous coating and its preparing method

Examples

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Effect test

Embodiment 1

[0018] Disperse zinc-containing nano-scale α-tricalcium phosphate powder in methanol, add lecithin and stir vigorously and apply ultrasonic emulsification to form emulsion A; relative to methanol, the amount of α-tricalcium phosphate powder is calculated by weight and volume 0.5%, the amount of lecithin is 0.1% by weight and volume; phosphate, calcium nitrate, manganese nitrate and hexafluorophosphoric acid are dissolved in methanol to form sol solution B, the Ca / P molar ratio is 1, and the Mn / Ca molar The ratio is 0.0001, and the F / Ca molar ratio is 0.001. Mix liquid A and liquid B at a volume ratio of 1:50 to form a coating liquid, use the sol-gel dipping method to coat the surface of the medical substrate, and heat treat at 500°C under a nitrogen atmosphere. The structure of the heterogeneous coating on the surface of the medical substrate is as follows figure 1 shown.

Embodiment 2

[0020] Disperse magnesium-containing nano-sized β-tricalcium phosphate powder in ethanol, add lecithin and stir vigorously, and apply ultrasonic emulsification to form emulsion A; relative to ethanol, the amount of β-tricalcium phosphate powder is calculated by weight and volume 1%, the amount of lecithin is 5% by weight and volume; phosphoric acid ester, calcium nitrate, manganese nitrate and ammonium fluoride are dissolved in ethanol to form sol solution B, the Ca / P molar ratio is 2, and the Mn / Ca molar The ratio is 0.05, and the F / Ca molar ratio is 0.2. Mix liquid A and liquid B at a volume ratio of 1:1 to form a coating liquid, coat the surface of the medical substrate by spin coating, and heat treat at 600°C under a nitrogen atmosphere.

Embodiment 3

[0022] Disperse strontium-containing nano-scale calcium carbonate powder in ethanol, add lecithin to vigorously stir and apply ultrasonic emulsification to form emulsion A; relative to ethanol, the amount of calcium carbonate powder is 25% by weight and volume, lecithin The dosage is 6% by weight and volume; phosphate ester, calcium nitrate, manganese nitrate and monofluorophosphoric acid are dissolved in ethanol to form sol solution B, the Ca / P molar ratio is 1.67, the Mn / Ca molar ratio is 0.005, and the F / Ca The molar ratio was 0.05. Mix liquid A and liquid B at a volume ratio of 1:25 to form a coating liquid, use the solution thermal spraying method to coat the surface of the medical substrate, and heat-treat at 700°C in an air atmosphere containing ethanol vapor.

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Abstract

The present invention discloses a medical material with heterogeneous coating layer and its preparation method. It is composed of medical matrix and heterogeneous coating layer coated on the surface of said medical matrix, the described heterogeneous coating layer is formed by distributing zinc, magnesium or strontium contained calcium phosphate or calcium carbonate coacervate whose gain size is 200nm-20 microns into the calcium phosphate coating layer containing manganese and containing fluorine, in which the surface of calcium phosphate coating layer containing manganese or containing fluorine has high surface potential adsorption function, it is favorable for promoting adsorption of cell on its surface, the zinc, magnesium or strontium contained calcium phosphate or calcium carbonate coacervate has ion-releasing function, it can utilize the mode of releasing beneficial ions to promote cytogenic protein secretion and promote mineralization, etc.

Description

technical field [0001] The invention relates to a medical biological material, in particular to a medical material used for hard tissue repair, which has a heterogeneous coating composed of two micron-scale blocks with different functions on the surface and a preparation method thereof. Background technique [0002] Since hard tissues such as bones and teeth are mostly located in the load-bearing parts, correspondingly, while considering whether the implant can produce good bonding with the living tissue, its mechanical properties are very important. However, it is difficult for a single material to meet the requirements of both mechanical properties and bioactive properties. At present, the method of coating a layer of active coating capable of depositing osteoid apatite on the surface of the medical metal substrate is mostly used. For example, the Chinese patent CN1064610 adopts a plasma spraying process to prepare a layer of hydroxyapatite coating on the dental metal sur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61K6/838A61L27/00A61L31/00
Inventor 程逵苗顺东翁文剑宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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