Composite porous calcium phosphate bone cement and method for making same

A technology of calcium phosphate bone cement and porous calcium phosphate, which is applied in the fields of medical science and prostheses, can solve the problems of low strength and slow degradation speed, and achieve the effects of fast degradation, accelerated degradation, and accelerated reconstruction

Inactive Publication Date: 2007-03-14
TSINGHUA UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to provide a composite porous calcium phosphate bone cement and a preparation method ther

Method used

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preparation example Construction

[0028] The preparation method of the present invention comprises the following steps:

[0029] (1) Prepare calcium phosphate bone cement solid phase powder (the known calcium phosphate bone cement has many kinds and can be used, and its preparation method is known technology, for example a kind of concrete preparation method of calcium phosphate bone cement solid phase powder is: α Type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio: α-type tricalcium phosphate / dicalcium phosphate / calcium carbonate=(8~12) / (1~2) / (3~5) without mixed by ball milling in water-ethanol medium, and dried at 80-100°C);

[0030] (2) Prepare simulated body fluid: add 8.00-24.00 grams of sodium chloride, 0.35-1.01 grams of sodium bicarbonate, 0.23-0.69 grams of potassium chloride, and 0.23-0.69 grams of dipotassium hydrogen phosphate in 1000 milliliters of deionized water or distilled water. 0.31-0.93 grams of magnesium chloride, 0.28-0.84 grams of calcium...

Embodiment 1

[0040] (1) Mix α-type tricalcium phosphate, calcium dihydrogen phosphate and calcium carbonate powder in molar ratio:

[0041] α-type tricalcium phosphate: calcium dihydrogen phosphate: calcium carbonate = 8: 1: 3, ball milling and mixing in absolute ethanol medium, and drying at 80°C to prepare calcium phosphate bone cement solid phase powder;

[0042] (2) Add 12 grams of sodium chloride, 0.53 grams of sodium bicarbonate, 0.34 grams of potassium chloride, 0.34 grams of dipotassium hydrogen phosphate, 0.46 grams of magnesium chloride, 0.42 grams of calcium chloride, and sodium sulfate in 1000 milliliters of deionized water or distilled water. 0.1 g, Tris 9.09, prepare simulated body fluid, and adjust the pH value of the simulated body fluid to 7.2 with 1 molar hydrochloric acid solution;

[0043] (3) PHBV microspheres were dosed with Co 60 gamma rays for irradiation treatment;

[0044] (4) Wash and dry the PHBV microspheres after (3) irradiation treatment with deionized wate...

Embodiment 2

[0052] (1) Mix α-type tricalcium phosphate, calcium hydrogen phosphate, tetracalcium phosphate and calcium carbonate powder in molar ratio:

[0053] α-type tricalcium phosphate: calcium hydrogen phosphate: tetracalcium phosphate: calcium carbonate = 10:1:1.5:3, ball milling and mixing in absolute ethanol medium, drying at 80°C to prepare calcium phosphate bone cement solid phase powder;

[0054] (2) Add 8.00 grams of sodium chloride, 0.35 grams of sodium bicarbonate, 0.23 grams of potassium chloride, 0.23 grams of dipotassium hydrogen phosphate, 0.31 grams of magnesium chloride, 0.28 grams of calcium chloride, and 0.28 grams of calcium chloride in 1000 milliliters of deionized water or distilled water. Sodium 0.07 gram, Tris 6.06 gram, preparation simulated body fluid, and the pH value of simulated body fluid is adjusted to 7.3 with the hydrochloric acid solution of 1 molar concentration;

[0055] (3) PHBV microspheres were dosed with Co 60 gamma rays for irradiation treatmen...

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Abstract

The invention relates to compound porous calcium orthophosphate skeleton cement. Wherein, said cement is formed by calcium orthophosphate skeleton cement powder, 3-hydroxy butanoic acid-CO-3-hydroxy pentanoic acid polymer microball, and solidify liquid. And the production comprises: preparing orthophosphate skeleton cement solid powder; preparing analogue humor; mixing the PHVV microball radiated by Co60 gama-ray; washing, drying and emerging it in the analogue humor, to be washed and dried; then mixing the PHBV microball and solid powder, to be added with solidify liquid to obtain the product. The invention has high strength, quick degradation and controllable degradation speed. And it can be used to repair skeleton hurt and used as skeleton support.

Description

technical field [0001] The invention belongs to the technical field of calcium phosphate bone cement composite materials, in particular to a composite calcium phosphate bone cement composite material capable of degrading in vivo to form pores and a preparation method thereof. Background technique [0002] Self-curing calcium phosphate bone cement has in-situ curing at room temperature or human physiological environment temperature, the structure and composition of the cured body are similar to the structure and composition of natural bone mineral phase, it can be shaped arbitrarily during surgery, and can fill bone defects of various shapes, etc. It can be widely used in clinical fields such as fracture fixation, bone defect repair, dental and maxillofacial surgery repair, and drug carrier. It is a research hotspot in the field of bone repair and hard tissue replacement materials. [0003] Although the ordinary calcium phosphate bone cement material also has a certain porosi...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/58A61L27/56
Inventor 董利民王晨昝青峰刘海兰李兆新田杰谟
Owner TSINGHUA UNIV
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