Pharmaceutical compositions with improved dissolution

US20050025791A1Inactive Publication Date: 2005-02-03TRANSFORM PHARMACEUTICALS INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
TRANSFORM PHARMACEUTICALS INC
Publication Date
2005-02-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound / excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a recrystallization / precipitation retardant and an optional enhancer.
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Description

FIELD OF THE INVENTION The present invention relates to pharmaceutical compositions and methods for preparing same. BACKGROUND OF THE INVENTION Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a substituted pyrazolylbenzenesulfonamide represented by the structure: Celecoxib belongs to the general class of non-steroidal anti-inflammatory drugs (NSAIDs). Unlike traditional NSAIDs, celecoxib is a selective inhibitor of cyclooxygenase II (COX-2) that causes fewer side effects when administered to a subject. The synthesis and use of celecoxib are further described in U.S. Pat. Nos. 5,466,823, 5,510,496, 5,563,165, 5,753,688, 5,760,068, 5,972,986, and 6,156,781, the contents of which are incorporated by reference in their entirety. Orally deliverable liquid formulations of celecoxib are discussed in U.S. Patent Application Publication No. 2002 / 0107250 in the name of Hariharan, et al., the contents of which are incorporated herein by reference...

Claims

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