Water-soluble magnetic or metal oxide nanoparticles coated with ligands, preparation method and usage thereof

a technology of magnetic or metal oxide nanoparticles and ligands, applied in the direction of granular delivery, powder delivery, energy modified materials, etc., can solve the problems of difficult control of the size of the nanoparticle, low crystallinity of the nanoparticle, and non-stoichiometric compound, etc., and achieve the effect of stably dissolving

Inactive Publication Date: 2009-10-15
IND ACADEMIC CORP FOUND YONSEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029]Accordingly, in order to provide magnetic or metal oxide nanoparticles that are stable in an aqueous solution while maintaining intrinsic electrical/optical/magnetic properties, the present inventors have found that water-soluble magnetic or water-soluble metal oxide nanoparticles can be prepared from water-insoluble magnetic or metal oxide nanoparticles synthesized in

Problems solved by technology

However, the water-soluble nanoparticles synthesized using the above methods have the following disadvantages.
In such cases, it is difficult to control the size of the nanoparticles, the synthesized nanoparticles have a non-uniform size distribution, the crystallinity of the nanoparticles is low due to the low-temperature synthesis, and a non-stoichiometric compound is formed.
However, since the size, shape, size distribution, crystallinity, and stoichiometry of the nanoparticles greatly affect the electrical/optical/magnetic/catalytic properties thereof, the magnetic nanoparticles developed to date have exhibited weak magnetic properties, and the metal oxide nanoparticles have exhibited poor electrical/optical properties.
Moreover, their low colloidal stability in aqueous solution leads aggregation and non-selective binding in biological applications.
When the magnetic nanoparticles having such problems are used as critical materials in electronic information technology and biotechnology, they show limitations.
For example, the nanoparticles developed to date have low biomaterial separation efficiency, low signal amplification effects as the diagnostic probe

Method used

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  • Water-soluble magnetic or metal oxide nanoparticles coated with ligands, preparation method and usage thereof
  • Water-soluble magnetic or metal oxide nanoparticles coated with ligands, preparation method and usage thereof
  • Water-soluble magnetic or metal oxide nanoparticles coated with ligands, preparation method and usage thereof

Examples

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example 1

Synthesis of Water-Soluble Iron Oxide, Manganese Ferrite, Cobalt Ferrite, Nickel Ferrite, Zinc Ferrite, and Zinc-Manganese Ferrite. Nanoparticles Coated with Bovine Serum Albumin (BSA, LI-LIII)

[0115]Water-insoluble iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zinc-manganese ferrite nanoparticles were synthesized according to the technique disclosed in Korean Patent Application Nos. 2004-0070303 and 2004-0070304, filed by the present inventors. All of the obtained nanoparticles were observed to have a particle size of about 12 nm, as intended, and to have a uniform size distribution and high crystallinity (FIG. 2).

[0116]The water-insoluble nanoparticles (5 mg) were dispersed in 1 ml of 1 M NMe4OH butanol solution and were then mixed for about 5 minutes, until uniform. Thereafter, a blackish brown precipitate was formed, and this precipitate was separated through centrifugation (2000 rpm, room temperature, 5 min). 10 mg of BSA was dissolved in 1 ml ...

example 2

Synthesis of Water-Soluble Iron Oxide, Manganese Ferrite, Cobalt Ferrite, Nickel Ferrite, Zinc Ferrite, and Zinc-Manganese Ferrite Nanoparticles Coated with Human Serum Albumin (HSA, LI-LIII)

[0117]As water-insoluble iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zinc-manganese ferrite nanoparticles, the same iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zinc-manganese ferrite nanoparticles as those of Example 1 were used. The water-insoluble nanoparticles (5 mg) were dispersed in 1 ml of 1 M NMe4OH butanol solution and were then mixed for about 5 minutes, until uniform. Thereafter, a blackish brown precipitate was formed, and this precipitate was separated through centrifugation (2000 rpm, room temperature, 5 min). 10 mg of HSA was dissolved in 1 ml of deionized water and was then mixed with the above precipitate, thus synthesizing iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zin...

example 3

Synthesis of Water-Soluble Iron Oxide, Manganese Ferrite, Cobalt Ferrite, Nickel Ferrite, Zinc Ferrite, and Zinc-Manganese Ferrite Nanoparticles Coated with Human ImmunoGlobulin G (hIgG, LI-LIII)

[0118]As water-insoluble iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zinc-manganese ferrite nanoparticles, the same iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, and zinc-manganese ferrite nanoparticles as those of Example 1 were used. The water-insoluble nanoparticles (5 mg) were dispersed in 1 ml of 1 M NMe4OH butanol solution and were then mixed for about 5 minutes, until uniform. Thereafter, a blackish brown precipitate was formed, and this precipitate was separated through centrifugation (2000 rpm, room temperature, 5 min). 10 mg of hIgG was dissolved in 1 ml of deionized water and was then mixed with the above precipitate, thus synthesizing iron oxide, manganese ferrite, cobalt ferrite, nickel ferrite, zinc ferrite, an...

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Abstract

This invention provides water-soluble magnetic or water-soluble metal oxide nanoparticles, which are coated with phase transfer ligands having an adhesive region, an adhesive region-crosslinking region, or an adhesive region-reactive region, and also provides a method of preparing water-soluble magnetic or metal oxide nanoparticles, the method including (1) synthesizing water-insoluble magnetic or metal oxide nanoparticles in an organic solvent; (2) dissolving the water-insoluble magnetic or metal oxide nanoparticles in a first solvent and dissolving a phase transfer ligand in a second solvent; and (3) mixing the two solutions achieved in step (2) to thus exchange the surface of the water-insoluble magnetic or metal oxide nanoparticles with the phase transfer ligand. Further, the water-soluble magnetic and water-soluble metal oxide nanoparticles coated with the phase transfer ligand can be used in various fields, including the separation and detection of materials, the diagnosis and treatment of diseases, and the decomposition of microorganisms and contaminants.

Description

TECHNICAL FIELD[0001]The present invention relates to water-soluble magnetic or water-soluble metal oxide nanoparticles, and a preparation method and usage thereof, and more particularly, to water-soluble magnetic or water-soluble metal oxide nanoparticles, in which the magnetic or metal oxide nanoparticles are coated with phase transfer ligands composed of an adhesive region, an adhesive region-crosslinking region, or an adhesive region-reactive region, to a method of preparing water-soluble magnetic or metal oxide nanoparticles from water-insoluble magnetic or metal oxide nanoparticles through phase transfer, and to the usage of the water-soluble magnetic or metal oxide nanoparticles in various fields, including the separation and detection of materials, the diagnosis and treatment of diseases, and the decomposition of microorganisms and contaminants.BACKGROUND ART[0002]Generally, magnetic nanoparticles and metal oxide nanoparticles, which exhibit intrinsic magnetic, optical and e...

Claims

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Application Information

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IPC IPC(8): A61K9/14G01N27/26B32B15/02G01N27/00G01N33/00C12Q1/70G01N33/53
CPCA61K41/0042Y10T436/143333A61K49/1833A61K49/1836A61K49/1854A61K49/1857A61K49/186A61K49/1863A61K49/1866A61K49/1869A61K49/1875A61L2/238A61L27/50A61L2400/12A61L2400/18B82Y5/00Y10T428/2993Y10T428/2991A61K41/0052A61P31/04A61P35/00A61P43/00B60H1/00378B60H1/00428B60H1/0075B60H1/03B60H1/3232B60Y2200/145
Inventor CHEON, JIN WOOJUN, YOUNG WOOKCHOI, JIN SIL
Owner IND ACADEMIC CORP FOUND YONSEI UNIV
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