Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs

Abstract

The invention describes a new class of crystalline silica material having two levels of porosity and structural order. At the first level, building units are nanoslabs of uniform size having zeolite framework. At the second structural level, nanoslabs are assembled, e.g. linked through their corners, edges or faces following patterns imposed by interaction with cationic surfactant or triblock copolymer molecules. After evacuation of these molecules, microporosity is obtained inside the nanoslabs, and a precise mesoporosity between the nanoslabs depending on the tiling pattern of the zeolite nanoslabs, as evidenced by X-ray diffraction. These materials are useful for the fixation of biologically active species, such as poorly soluble drugs.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 10 / 562,307 filed on Dec. 23, 2005, which is the U.S. National Stage of International Application No. PCT / BE2004 / 000094, filed Jun. 28, 2004, which in turn, claims the benefit of GB Application No. 0315012.5, filed Jun. 27, 2003, the disclosures of which are incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention relates a new class of crystalline silica, said materials having two levels of porosity and structural order and their use for fixation and release of biological and chemical compounds, e.g. drugs.BACKGROUND OF THE INVENTION[0003]Porous inorganic solids have found great utility as catalysts and separations media for industrial application. The openness of their microstructure allows molecules to access the relatively large surface areas of these materials and enhances their catalytic activity and adsorption capacity...

AI Technical Summary

Benefits of technology

[0039]The present invention is based on the unexpected finding that both problems of improving the reproducibility of mesoporous oxide based materials and/or of formulating poorly soluble drugs, especially for immediate release, can be solved at the same time by providing a substantially crystalline mesoporous oxide based material, e.g. a silica material, being obtained by assembly of nanometer size building units having zeolite framework, wherein said assembly proceeds in the presence of one or more amphiphilic non-anionic surfactants, wherein said substantially crystalline mesoporous oxide based material has two or more levels of porosity and structural order, and wherein the internal structure of said nanometer size building units do not give rise to Bragg type diffraction in a powder X-ray dif

Problems solved by technology

However, the molecular size of a reactant which can be utilized in catalytic conversion reactions, etc. is limited by the pore size of zeolite because zeolite is a microporous molecular sieve.

However, these molecular sieves cannot exceed the microporous limit.

A significant problem of the presently known fully crystalline microporous molecular sieve is that it cannot be used in reactions of molecules larger than about 1.3 nm in size.

The pore distribution curves of FIG. 14 show that the more conversion is obtained in step (c), the more structural order is lost at the mesoporous level; in practice this means that reproducibility of the material may be impaired by an inaccurate control of the crystallization time. FIG. 15 also clearly shows that structural order obtained at the mesoporous level in step (a) is lost in steps (b) and (c) when zeolitic structure appears.

The possibility to transform part of the amorphous walls of a mesoporous precursor into zeolite framework was already demonstrated, but segregation of a zeolite phase from the mesostructure

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