The invention provides a self-adaptive plugging device. The self-adaptive plugging device is characterized by comprising a first plugging disc and a second plugging disc which are used for plugging blood flows of coloboma positions, the first plugging disc is connected with one end of a connecting waist portion which can be stretched and deflected, and the other end of the connecting waist portion which can be stretched and deflected is connected with the second plugging disc. According to the self-adaptive plugging device, the connecting waist portion can be stretched and deflected; by means of stretching and deflection of the connecting waist portion, the functions of adjusting the length and the angle of deflection of the plugging device can be achieved; generally, certain included angles exist between aortas and pulmonary arteries, and under the action of the adjustable waist portion, the plugging discs on the two sides can be well attached to the wall faces of catheters of the aortas and the pulmonary arteries respectively, and the main performances such as the rebound resilience, the fixity and the plugging effect of the plugging device are significantly improved.