16 results about "Subsegmental pulmonary artery" patented technology

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

To provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue.SOLUTION: In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective in injuring or damaging tissue, nerves and nerve endings in order to relieve disease symptoms.SELECTED DRAWING: Figure 3B

The invention relates to an application of a THBS4 inhibitor in preparation of a medicine for preventing and / or treating pulmonary arterial hypertension. Three pulmonary arterial hypertension rat models (a hypoxia induction model, a hypoxia combined SUGEN induction model and a monocrotaline induction model) are constructed, the expression change of THBS4 is verified through qRT-PCR and western blot, and the correlation between the expression level of THBS4 and pulmonary arterial hypertension is verified in combination with in-vitro cell experiments and in-vivo intervention. Results show that THBS4 is remarkably up-regulated in pulmonary arteries of the three models, the expression level of THBS4 is positively correlated with the severity of diseases, and THBS4 is an important regulatory factor for promoting vascular remodeling in pulmonary arterial hypertension. In vivo, by knocking down THBS4, pulmonary vascular remodeling and right ventricular hypertrophy are remarkably relieved, and it is prompted that THBS4 inhibitors show good application prospects in the aspect of preventing and / or treating pulmonary arterial hypertension.

The present application provides a bronchial extraction method, device and computer equipment based on CT images, which relates to the field of CT image processing technology. The method includes: obtaining a lung electronic computer tomography CT image to be segmented; segmenting the CT image to obtain a pulmonary interstitial mask image, a bronchial mask image and a pulmonary artery mask image; segmenting the bronchial mask image to obtain at least three bronchial segment mask images, segmenting the pulmonary artery mask image to obtain at least three pulmonary artery segment masks, determining the classification result of the bronchial mask image based on the adjacent and docking relationship of each bronchial segment, and determining the classification result of the pulmonary artery mask image based on the adjacent and docking relationship of the pulmonary artery; fusing the classification result of the bronchial mask image and the classification result of the pulmonary artery mask image, and generating the final bronchial mask image based on the accompanying relationship of the pulmonary artery corresponding to the bronchi.

The invention provides an application of lncRNA-92467 as a marker in preparation of a product for early warning and / or diagnosing altitude sickness. Particularly, the expression level of lncRNA-92467 in pulmonary arteries or cells of rats in a simulated plateau environment is remarkably reduced. And the regulation of the expression level of the lncRNA-92467 is directly related to the proliferation, migration and apoptosis of the HPAECs cells.

The invention discloses a removing device, and relates to the technical field of medical instruments. The removing device comprises a conveying guide pipe, a push-pull piece and a remover. The conveying catheter is provided with a first cavity channel and a second cavity channel, and the first cavity channel is used for the guide wire to pass through; the push-pull piece is movably arranged in the second cavity channel at least in the axial direction of the conveying catheter; the remover and the far end of the push-pull part are connected or integrally formed, the remover is used for scraping away a fibrous protein sheath on the outer surface of the central venous catheter, and the push-pull part is used for controlling the remover to be switched between a storage position and an unfolding position and adjusting the size of the remover; at the storage position, the cleaner is folded in the second cavity; in the deployed position, the scavenger is open and located outside the delivery catheter. The invention provides a removing device which is used for removing fibrous protein sheaths on the surface of a central venous catheter, the central venous catheter does not need to be frequently replaced, the treatment cost is lower, the pain of a patient is reduced, and pulmonary embolism caused by the fact that the fibrous protein sheaths enter pulmonary arteries is avoided.

The present invention relates to a biodegradable, resorbable stent, comprising a structure consisting of a metal alloy of magnesium with transition metals and / or rare earths, wherein the structure is encased by a polymer and the encased structure has struts of stent elements, wherein the stent can be a valve-bearing stent. The present invention also relates to the use of the disclosed stent without valves, or of a system comprising a corresponding stent for implantation in the case of congenital heart defects for opening a pulmonary artery, for keeping open a ductus arteriosus Botalli, for keeping open an aortic isthmus stenosis for incentivising growth in hypoplastic pulmonary arteries, or as an oesophagus stent, or as a ureter support.

The invention belongs to the technical field of medical instruments, and particularly relates to a catheter. The catheter comprises a catheter body and a guide head connected to the far end of the catheter body. The tube body sequentially comprises a lining layer, a supporting layer and an outer layer from inside to outside, the far end of the lining layer extends into the seeker and is connected with the seeker, and the far end of the outer layer is arranged on the peripheral wall of the seeker in a sleeving mode and is connected with the seeker. The guide head is arranged at the far end of the catheter body and serves as a flexible guide functional component of the catheter, and the core function of the guide head is that after the catheter enters a human body, the guide head can guide the catheter in a flexible mode by means of the structural characteristic of flexible guide of the guide head. The catheter is guided to smoothly penetrate through blood vessels of special parts such as intracranial blood vessels and pulmonary arteries, the blood vessels generally have the characteristics of dense network distribution, tortuous walking paths, thin and brittle blood vessel walls, complex angle change and the like, and the flexible guide design of the guide head can adapt to the structural characteristics of the blood vessels. Friction and damage of the catheter to the blood vessel wall are reduced, and it is ensured that the catheter accurately reaches the target position.

Methods for assessing the efficacy of Seralutinib treatment for PAH in subjects suffering from PAH are provided, as well as methods for increasing the ratio of the volume of distal pulmonary arteries relative to the volume of proximal pulmonary arteries (BV510ARatio) by administering to the subject an effective amount of Seralutinib. Also provided are methods for increasing the pulmonary vascular volume of small arterial vessels, as well as decreasing the dilation of larger pulmonary arterial vessels, in a subject in need thereof by administering to the subject an effective amount of Seralutinib.

This invention belongs to the field of medical device technology, and particularly relates to a guiding catheter for pulmonary arteries, including a catheter hub, one end of which is detachably connected to a tube body. The end of the tube body away from the catheter hub has a curved structure, and the tube body is a radiopaque tube. The detachable connection of the tube body to the catheter hub facilitates the replacement of tubes with different curved structures, saving surgical time. The radiopaque design of the tube body enhances the surgeon's ability to identify the target location, helping to more accurately assess the condition and formulate a surgical plan. This invention establishes access within the narrow, tortuous, and complex branches of the pulmonary artery, allowing patients to receive effective treatment during a stressful treatment process.

The invention discloses a self-expanding intravascular stent, and relates to the field of medical instruments, the self-expanding intravascular stent comprises a net-shaped stent and a covering film, the net-shaped stent comprises a net-shaped outer cylinder and a net-shaped inner cylinder, the net-shaped inner cylinder is arranged in the net-shaped outer cylinder, and the two ends of the net-shaped inner cylinder are connected with the two ends of the net-shaped outer cylinder respectively; the net-shaped outer cylinder and the net-shaped inner cylinder are both formed by weaving shape memory alloy wires, the net-shaped outer cylinder and the net-shaped inner cylinder are both provided with covering films, in the expansion state, the net-shaped outer cylinder is used for being supported on the inner wall of a blood vessel, and a center flow channel used for reducing blood flow is formed in the net-shaped inner cylinder. The self-expanding intravascular stent solves the problem that blood flow supply of left and right pulmonary arteries is unbalanced, namely the blood flow of the left pulmonary artery is far lower than the blood flow of the right pulmonary artery, in a child patient suffering from Fallot quadruple syndrome and pulmonary artery atresia.

The invention discloses an application of BMAL1 overexpressed adenovirus in pulmonary arterial hypertension treatment, the application is that the BMAL1 overexpressed adenovirus can relieve proliferation and migration of pulmonary arterial smooth muscle in pulmonary arterial hypertension, and specifically, the overexpressed adenovirus is constructed, and a rat pulmonary arterial smooth muscle cell BMAL1 overexpressed model is constructed by using a transfection technology. By constructing a mouse pulmonary vessel BMAL1 overexpression model, it is elaborated that BMAL1 can effectively inhibit vascular remodeling of pulmonary arteries under the hypoxia condition by adjusting related signal channels, pulmonary arterial pressure can be relieved, right heart pressure can be reduced by explaining BMAL1 overexpression of pulmonary vessels, pulmonary vessel injury can be relieved, and therefore clinical symptoms of pulmonary arterial hypertension are improved; the invention discloses an important role of the BMAL1 overexpressed adenovirus in pulmonary arterial hypertension, and provides a potential target for developing a novel treatment method aiming at the disease.

Pulmonary flow regulating device. The pulmonary flow regulating device (100) is constructed using braided / stented Nitinol mesh (110) with ePTFE covering (210) wherein the braided / stented Nitinol mesh (110) comprising of memory retention properties. The braided / stented Nitinol mesh (110) is heat treated to achieve the memory retention properties of the pulmonary flow regulating device (100). The ePTFE covering (210) provides restriction to the flow of blood to the pulmonary arteries thereby effectively controlling the flow of blood to the lungs of the mammalians (Human).

The present disclosure provides a pulmonary blood vessel segmentation method, device, electronic device and storage medium. The method includes: performing lung segmentation on a chest image to determine a lung image in the chest image; performing intra-hilar artery and vein segmentation on the lung image to determine an intra-hilar artery and vein segmentation mask image in the lung image; performing intra-pulmonary tissue artery and vein segmentation on the lung image, combining the intra-hilar artery and vein segmentation mask image to determine a pulmonary tissue artery and vein segmentation mask image in the lung image; merging the intra-hilar artery and vein segmentation mask image with the pulmonary tissue artery and vein segmentation mask image to obtain an artery and vein image in the chest image, achieving accurate segmentation of pulmonary arteries and veins in a plain scan chest image, being able to effectively capture the details of the vascular structure, especially in the absence of a contrast agent, improving the visualization effect of pulmonary blood vessels in the chest image.

Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspensions of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.

A system for generating an estimated pulmonary artery occlusion pressure (PAOP) measurement on an ongoing basis, without occlusion of pulmonary arteries, includes one or more sensing devices that produce one or more sensor signals. The system estimates the PAOP measurement based upon the one or more sensor signals from the one or more sensing devices, and displays the estimated PAOP measurement via a display device. In some examples, the system displays an indication of whether the estimated PAOP measurement of a patient is elevated, based upon the estimated PAOP measurement exceeding a predetermined threshold.