The invention discloses N, -2 substituted phenyl derivates of 4-methoxyl-1, 3-phenylene acyl diamine, and the usage thereof. A compound provided by the invention has the activity for inhibiting the collection of blood platelet, and is applicable for the diseases such as miocardial infarction, cerebrovascular disorder, pulmonary embolism, atherosclerosis, and so on. Moreover, the compound also has the activities of antifebrile, pain killing, inflammation resisting, and so on.