50 results about "Lung embolism" patented technology

The invention discloses a CT (Computed Tomography) image pulmonary embolism segmentation and classification method combined with quality evaluation, which relates to the technical field of image processing, and comprises the following steps: inputting a 256 * 256 pulmonary embolism CT image and a quality score thereof into a quality score guide encoder, expanding a quality score dimension through linear transformation, and carrying out point product fusion with a feature map extracted by ResNet34 layer by layer to obtain a final product; generating multi-scale coding features; performing wavelet domain decomposition and reconstruction on the coding features through a wavelet transform fusion jump link module, and optimizing feature transmission; a multi-scale cross enhanced decoder is adopted to carry out multi-scale deconvolution fusion on the features, a segmentation result is output in combination with an efficient channel attention mechanism, meanwhile, pulmonary embolism existence judgment is output through a classification head, and the method provides powerful support for early diagnosis of pulmonary embolism, development of an image auxiliary diagnosis system and clinical application, and has good application prospects. Wide application prospects and profound social significance are realized.

The invention relates to the technical field of medical information processing, and discloses an acute pulmonary embolism auxiliary diagnosis decision-making system based on a large model, and the system comprises a data collection and preprocessing module which is used for receiving multi-source clinical data and preprocessing the multi-source clinical data; the large model reasoning module is used for inputting the preprocessed multi-source clinical data into a large model fused with a multi-modal causal attention and identification adversarial learning mechanism, and outputting a reasoning result; the dynamic learning module is used for accessing desensitized case data of a hospital electronic medical record system, continuously learning new cases through federal learning, and optimizing the recognition capability of a large model pair; the diagnosis suggestion generation module is used for generating structured diagnosis suggestions according to the reasoning result output by the large model; the result output and interaction module is used for displaying diagnosis suggestions to doctors and updating reasoning results in real time by a large model when the doctors supplement data; the diagnosis efficiency is improved.

The invention belongs to the field of pulmonary embolism detection and segmentation, and discloses a residual error jump enhancement and multi-dimensional interactive attention combined network structure, which comprises an encoder, a decoder, a jump connection fusion module and a bottleneck module which are respectively responsible for feature extraction, spatial restoration, multilayer semantic fusion and modeling of a long-distance dependency relationship. The AGRS module is fused with a residual jump enhancement structure and a multi-dimensional interaction quadruple attention module; the CDB-ASPP module realizes multi-scale context information efficient fusion through five parallel convolution branches with different expansion rates, combines a global-local enhancement strategy, and considers both a global receptive field and a local detail perception capability; and a dual attention Transform module is used for enhancing the global feature modeling capability. According to the method, an effective solution is provided for solving key problems such as semantic gaps, context information missing and small target detection sensitivity, and important reference and enlightenment are provided for deep learning-based pulmonary embolism auxiliary diagnosis research.

A method of assessing a likelihood of a patient having a pulmonary embolism (PE) comprises receiving discrete patient data, including patient-related clinical and demographic data pertinent to the patient, receiving electrocardiograph (ECG) waveform data obtained from examination of the patient, processing both the received discrete patient data and received set of ECG waveform data using a supervised deep learning multimodal fusion model that has been trained using analogous input training data including both discrete patient data and ECG waveform data to obtain an optimal match to results from corresponding patient computed tomography pulmonary angiograms (CTPA), indicative of a presence or absence of a pulmonary embolism, and outputting a measure of the likelihood of the patient having a pulmonary embolism.

This invention discloses a method, device, electronic equipment, and medium for assessing the risk of pulmonary embolism. It relies entirely on collected non-invasive objective data and eliminates subjective judgments based on medical history or physician experience, effectively avoiding risk misjudgments caused by subjective variables in the PESI / sPESI model. This ensures the consistency and reliability of the assessment results. The ratio of Qa to Qb is used as the core assessment indicator. This ratio is a continuous variable, eliminating the need for empirical segmentation of parameters and avoiding significant differences in assessment results among patients with similar conditions. The risk level is assessed based on the ratio of Qa to Qb obtained through hemodynamic simulation. The results perfectly match clinical understanding of the severity of pulmonary embolism, improving assessment accuracy. Simultaneously, it reduces patient examination trauma and avoids high equipment and operational costs.

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The invention relates to a pulmonary embolism image segmentation method and device based on a deep residual network, and relates to the technical field of deep learning. The method comprises the following steps: inputting a training set image with a pulmonary embolism labeling area into a preset deep residual network, and extracting multi-layer image features of the training set image; performing feature fusion on the multi-layer image features to generate a segmented image with a pulmonary embolism prediction area; decoding and reconstructing the multi-layer image features based on an attention guidance mechanism, and generating a multi-layer attention map with a pulmonary embolism prediction area; constructing a comprehensive loss function according to the segmented image, the multi-layer attention map and the training set image, and optimizing model parameters of the deep residual network based on the comprehensive loss function; and performing pulmonary embolism region segmentation labeling on the to-be-segmented image by using the optimized deep residual network. By adopting the method, the feature expression capability and the small target recognition capability of the pulmonary embolism image can be improved.

A vacuum aspiration system may be used to treat thromboembolic disease, such as deep vein thrombosis or pulmonary embolism. The system includes a housing, and a fluid flow path extending through the housing. An aspiration catheter is in fluid communication with the flow path, and a connector is configured to place a source of aspiration in communication with the flow path. A hemostasis valve is provided in the housing. The housing may be configured to receive and releasably engage a thrombus engagement tool.

The present invention relates to the technical field of biology, and in particular to a nucleic acid targeting coagulation factor XI and a use thereof. The nucleic acid of the present invention can effectively reduce the level of coagulation factor XI and can effectively inhibit the formation of thrombi, thereby preventing and / or treating multiple diseases caused by thrombi, such as pulmonary embolism, venous embolism, deep venous embolism, myocardial infarction, and stroke.

The application discloses a CT image pulmonary embolism segmentation and classification method combined with quality evaluation, relates to the technical field of image processing, and comprises the following steps: inputting a 256*256 pulmonary embolism CT image and a quality score thereof into a quality score guided encoder, expanding the quality score dimension through linear transformation, point multiplying and fusing with feature maps extracted by ResNet34 layer by layer, and generating multi-scale coding features; carrying out wavelet domain decomposition and reconstruction on the coding features through a wavelet transform fusion skip link module, and optimizing feature transmission; adopting a multi-scale cross enhancement decoder to perform multi-scale deconvolution fusion on the features, outputting a segmentation result in combination with an efficient channel attention mechanism, and outputting a pulmonary embolism existence judgment through a classification head, so that the method provides strong support for early diagnosis of pulmonary embolism, development of an image assisted diagnosis system and clinical application, and has wide application prospect and far-reaching social significance.

The invention relates to the technical field of risk prediction of diseases, in particular to a pulmonary embolism risk layering method and system and a storage medium. The pulmonary embolism risk layering method comprises the following steps: inputting a CTPA image into an image segmentation model to obtain a segmented image which is output by the image segmentation model and marked with a focus area; and inputting the segmented image into a prediction model to obtain a pulmonary embolism risk hierarchical prediction result output by the prediction model, the pulmonary embolism risk hierarchical prediction result being determined by the prediction model according to the image omics characteristics of the focus area, and the image omics features are extracted from the lesion area by the prediction model.

The invention discloses a pulmonary embolism risk prediction model for a critical community-acquired pneumonia patient and an establishment method. The method comprises the following steps: 1, inputting patient data; 2, sorting and cleaning data, especially processing missing values and abnormal values; 3, randomly splitting the data into a training set and a verification set in proportion, and performing population and baseline feature relationship analysis on the split data set; 4, the LASSO regression and the multi-factor logic regression are adopted to determine the independent risk factors of the intensive care unit-intensive community acquired pneumonia, the ICU-SCAP patient pulmonary embolism and the PE, and a risk prediction model is constructed on the basis of the training set; and 5, performing internal verification on the risk prediction model based on the verification set, and evaluating the distinction degree, the calibration degree and the clinical benefit of the risk prediction model. Based on the data processing strategy of the system, in combination with advanced modeling methods such as LASSO, GAM, RCS and the like, the PE risk of the ICU-SCAP patient is accurately evaluated, and the method has good technical advancement, stability and clinical practical value.

The invention discloses a pulmonary embolism detection system combining CT pulmonary arteriography and a neural network, and relates to the technical field of angiography image processing. Comprising five parts, namely CT pulmonary arteriography data collection, data set annotation and division, CT pulmonary arteriography image enhancement, data set amplification and data normalization, and is used for processing a patient image, wherein the CT pulmonary arteriography sequence image cleaning and enhancement network is composed of five parts, namely CT pulmonary arteriography data collection, data set annotation and division, CT pulmonary arteriography image enhancement, data set amplification and data normalization; the CT pulmonary arteriography multi-scale feature extraction network is composed of a residual transformation network and a bidirectional feature pyramid network and is used for extracting data features; the pulmonary embolus potential position detection network is composed of an independent self-attention mechanism and is used for detecting the position area of pulmonary embolus; the pulmonary embolism type identification and positioning network is composed of two identification modules connected in series and is used for pulmonary embolism type judgment and position positioning.

The present invention covers the use of chymase inhibitors in general and more in particular substituted bicyclically substituted uracils of general formula (I) as described and defined herein, and 3-methylbenzo-[b]thiophene)-2-sulfonamido derivatives of general formula (II) for manufacturing pharmaceutical compositions for the treatment or prophylaxis of stroke, pulmonary embolism, deep or superficial vein thrombosis, thrombotic microangiopathy, thrombotic microangiopathy in hypercoagulable states after infection, inflammation, transplantation, disseminated intravascular coagulation, vaccine-induced immune thrombotic thrombocytopenia, vascular access site thrombosis or occlusion.

The invention discloses a pulmonary embolism adverse event risk assessment method, device and equipment and a storage medium, a functional pulmonary embolism adverse event risk assessment model is constructed, three objective parameters of age, heart rate and blood oxygen partial pressure are directly incorporated into the model, weights of the age, the heart rate and the blood oxygen partial pressure are obtained through objective derivation (non-manual setting), and the risk assessment model is used for evaluating the risk of the pulmonary embolism adverse event. According to the method, the dependence on doctor experience is thoroughly eliminated, assessment deviation caused by subjective factors is avoided, the functional risk assessment model has continuity, and the problem that the assessment results of two patients with similar parameters are greatly different in the prior art is avoided.

The invention relates to the technical field of medical treatment. The lantern-shaped pulmonary embolism thrombus cleaning device comprises a driving cylinder, a suction cylinder arranged at the lower end of the driving cylinder and communicated with the driving cylinder, and a thrombus removing pipe capable of being placed in the thrombus position through a catheter. A suction piston which is matched with an inner cavity of the suction cylinder and moves in the vertical direction is arranged in the suction cylinder. A driving rod is arranged in the driving cylinder, and the lower end of the driving rod extends into the suction cylinder and is connected with the suction piston; the upper end of the driving cylinder is provided with a cylinder cover with a spiral hole in the center, the upper section of the driving rod is provided with a spiral section matched with the spiral hole, the spiral section of the driving rod is arranged in the spiral hole in a penetrating mode, and the upper end of the driving rod is connected with the tail plate through a rotating connector; the thrombus removing device can conduct rotary crushing cutting and suction on thrombus at the same time, the thrombus removing efficiency is greatly improved, and meanwhile the thrombus removing device is simple in structure and good in stability.

An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

The present invention relates to a plant composition, a traditional Chinese medicine composition and use thereof. The plant composition comprises Prepared Monkshood Daughter Root (Aconitum carmichaelii), Fragrant Solomonseal Rhizome (Polygonatum odoratum), Indian Bread (Poria cocos), Pinellia tuber (Pinellia ternata), Oriental Wormwood Herb (Artemisia scoparia), Scutellaria Root (Scutellaria baicalensis), Mongolian Snakegourd Fruit (Trichosanthes kirilowii), Magnolia Bark (Magnolia officinalis), Heartleaf Houttuynia Herb (Houttuynia cordata) and Baked Licorice Root and Rhizome (Glycyrrhiza glabra), which is used as a traditional Chinese medicine composition. In addition, the traditional Chinese medicine composition can be used to treat pulmonary embolism or pulmonary fibrosis.

The invention discloses a removing device, and relates to the technical field of medical instruments. The removing device comprises a conveying guide pipe, a push-pull piece and a remover. The conveying catheter is provided with a first cavity channel and a second cavity channel, and the first cavity channel is used for the guide wire to pass through; the push-pull piece is movably arranged in the second cavity channel at least in the axial direction of the conveying catheter; the remover and the far end of the push-pull part are connected or integrally formed, the remover is used for scraping away a fibrous protein sheath on the outer surface of the central venous catheter, and the push-pull part is used for controlling the remover to be switched between a storage position and an unfolding position and adjusting the size of the remover; at the storage position, the cleaner is folded in the second cavity; in the deployed position, the scavenger is open and located outside the delivery catheter. The invention provides a removing device which is used for removing fibrous protein sheaths on the surface of a central venous catheter, the central venous catheter does not need to be frequently replaced, the treatment cost is lower, the pain of a patient is reduced, and pulmonary embolism caused by the fact that the fibrous protein sheaths enter pulmonary arteries is avoided.

The invention relates to the technical field of computer-aided medical treatment, and discloses a pulmonary embolism grade evaluation method and device, equipment and a storage medium. Firstly, the embolus image and the cardiopulmonary structure index are obtained in an automatic mode, the step of manually obtaining data is omitted, time is saved, and errors caused by manual operation can be reduced. Then, performing prediction evaluation based on the embolism sub-image to obtain a preliminary pulmonary embolism level prediction result; combined prediction evaluation is carried out based on the embolism sub-images and the cardiopulmonary structure indexes in different modes, pulmonary embolism information is captured more comprehensively, and a combined pulmonary embolism level prediction result is obtained. And finally, integrating the preliminary pulmonary embolism grade prediction result and the combined pulmonary embolism grade prediction result, mutually supplementing and verifying the two results, and finally obtaining a target pulmonary embolism grade prediction result. And compared with a prediction result obtained by only depending on a single method, the accuracy of the prediction result of the target pulmonary embolism level is improved.

The invention discloses a pulmonary embolism identification and evaluation method based on electrical impedance tomography of a pulsation method, and belongs to the technical field of medical treatment. The method comprises the following steps: acquiring an electrical impedance signal through an electrode array surrounding the chest, separating a ventilation signal from a perfusion signal by using a preset algorithm, calculating a matching index, an image matching degree, a perfusion deficiency index and a ventilation deficiency index, judging a pulmonary embolism risk level by combining a blood flow to ventilation volume ratio, and generating a visual report; the method further comprises the steps of dynamic treatment effect monitoring, data processing, bedside monitoring, preparation before signal acquisition and the like. Noninvasive bedside identification of pulmonary embolism is achieved, the invasiveness, radiation risk and transfer limitation of traditional examination are avoided, the treatment effect can be evaluated in real time to assist scheme adjustment, diagnosis and treatment convenience and universality are improved, and reasonable allocation of medical resources and diagnosis and treatment standardization are assisted.

The invention relates to the technical field of medical treatment, and particularly discloses a classification detection system for lung cancer and pulmonary embolism, which is used for solving the problem that in the prior art, texture features related to lung cancer and pulmonary embolism are not extracted, and a model does not divide a focus area, so that an embolism position cannot be quickly found out when a film is read by using the model. According to the method, a healthy lung X-ray image set is acquired and summarized into a first lung image set, a lung cancer combined embolism lung X-ray image set is acquired and summarized into a second lung image set, embolism features are extracted according to the first lung image set and the second lung image set, and an embolism area is positioned and marked according to the embolism features; according to the method, extraction and analysis of the vascular sparseness and right cardiac shadow increase features are integrated, the embolism area is positioned in combination with machine learning, and the detection efficiency and accuracy of lung cancer combined pulmonary embolism are greatly improved.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to application of a traditional Chinese medicine composition in preparation of pulmonary embolism treatment substances, and the traditional Chinese medicine composition is mainly prepared from astragalus membranaceus, honeysuckle, golden cypress, rhizoma atractylodis, coix seeds, radix scrophulariae, angelica sinensis, radix paeoniae alba, liquorice, leech, centipede and scorpio. All the medicines in the traditional Chinese medicine composition conform to the principle of compatibility of monarch, minister, assistant and guide, compatibility is scientific, the traditional Chinese medicine composition is suitable for clinical cases, pharmacodynamic tests show that the composition can relieve inflammatory injury of rats suffering from acute pulmonary embolism, and clinical tests prove that the composition can effectively relieve symptoms of patients suffering from pulmonary embolism and is low in toxic and side effect, good in safety and wide in market prospect.

The invention relates to a venous thromboembolism knowledge base generation method and a storage medium. The method comprises the following steps that a big data acquisition layer in a hospital acquires venous thromboembolism data; the big data preprocessing and feature engineering layer performs cross-domain data standardization processing on the acquired venous thromboembolism data; the AI large model intelligent analysis layer analyzes the incidence relation of genetic variation-image features-clinical indexes through a VTE special large model constructed based on a Transform architecture in combination with graph neural network cross-modal knowledge reasoning, and mines a nonlinear mode of thrombus load and pulmonary embolism risk; the dynamic knowledge base generation layer constructs a VTE knowledge graph by using a graph database, and automatically updates the specific knowledge and timeliness knowledge of the carved department. Complex knowledge association in the VTE field is captured through an AI large model, and analysis of nonlinear relations and cross-domain features is enhanced.

This invention provides a pulmonary embolism detection and segmentation method based on intercalation distance compensation, belonging to the field of computer medical image processing technology. The method includes: pre-labeling and preprocessing a lung CT image set to obtain pre-labeled labels and a standard image set; obtaining thrombus labels from the pre-labeled labels; integrating the thrombus labels and the standard image set and inputting them into a 3D target detection network model for training to obtain a detection training model; performing detection and recognition through multiple detection training models to obtain multiple preliminary detection results and fusing them into a recognition result; integrating the thrombus labels, the standard image set, and the lung CT image set and inputting them into a semi-supervised semantic segmentation model for training to obtain a final segmentation model; and using the final segmentation model and an intercalation distance compensation mechanism to segment and correct the recognition result to obtain a merged result. This method intelligently identifies pulmonary embolism through deep learning and image processing, improving the detection accuracy of pulmonary embolism.

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The present invention covers the use of chymase inhibitors in general and more in particular substituted bicyclically substituted uracils of general formula (I) as described and defined herein, and 3-methylbenzo-[b]thiophene)-2-sulfonamido derivatives of general formula (II) for manufacturing pharmaceutical compositions for the treatment or prophylaxis of stroke, pulmonary embolism, deep or superficial vein thrombosis, thrombotic microangiopathy, thrombotic microangiopathy in hypercoagulable states after infection, inflammation, transplantation, disseminated intravascular coagulation, vaccine-induced immune thrombotic thrombocytopenia, vascular access site thrombosis or occlusion.

This invention discloses a method and system for constructing an AI-assisted diagnostic agent for pulmonary embolism based on ontology and knowledge graph, belonging to the fields of medical information systems and medical artificial intelligence technology. By integrating a pulmonary embolism-specific medical ontology, a clinically aligned knowledge graph, and thought chain reasoning, this invention leverages the hard constraints of ontology knowledge to achieve interpretability analysis of the entire process of AI-assisted diagnosis for pulmonary embolism, precise suppression of AI illusions specific to pulmonary embolism, end-to-end quality control, and closed-loop optimization. It is particularly suitable for rapid diagnosis of acute and critical pulmonary embolism, AI-assisted identification of pulmonary artery filling defects in CTPA images, thrombosis severity stratification, and emergency treatment decision tracing and regulatory compliance quality control scenarios. It can be adapted to the implementation, regulatory verification, and clinical optimization of various pulmonary embolism AI imaging diagnostic and emergency auxiliary diagnosis and treatment systems, specifically addressing core illusion problems in pulmonary embolism AI diagnosis such as false positive embolus identification and disordered risk stratification.

An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

The invention relates to the technical field of ultrasonic rotary-cut thrombus aspiration, in particular to an ultrasonic rotary-cut thrombus aspiration device for pulmonary embolism treatment, which comprises a catheter, a four-way valve is mounted at one end of the catheter, a monitoring mechanism and an aspiration mechanism are respectively arranged on two sides of the four-way valve, and a rotary-cut control mechanism is arranged in the middle of the four-way valve. The suction mechanism comprises a suction pipe in through connection with the interior of the guide pipe, one end of the suction pipe is in through connection with a suction pump, the bottom end of the suction pump is in through connection with the liquid storage tank, a plurality of suction open holes are formed in the other end of the suction pipe, and the suction pipe adopts a hypotube; the shape and the size of the blade are designed according to the characteristics of thrombus and the anatomical structure of blood vessels, the thrombus can be cut into small fragments, the small fragments can be conveniently drawn out through a suction pipe, the rotating speed and the cutting depth of the cutting blade can be accurately controlled to adapt to thrombus of different sizes and hardness, and the cutting efficiency is improved. And the cutting blade is regulated and controlled to perform rotary cutting through the arranged traction copper steel wire.