The invention relates to the technical field of planting and provides a comprehensive control method for the stem rot of passion fruits. The method comprises the steps of planting land selection and soil improvement, and execution of an after-planting prevention and treatment method. According to planting land selection and soil improvement, a slop field with loose soil, flat terrain and good ventilation and drainage is selected, planting pits are dug, the bottoms of the planting pits are filled with a soil regulator formed by mixing bamboo charcoal, straw and shaddock peel, half of surface soil is put back, the rest of surface oil, the bottom soil and a self-made fertilizer prepared from bamboo charcoal, ammonuim humate, chicken manure, pig manure, compound fertilizer, shells of shelled animals, bentonite, copper acetate and sodium lignosulfonate are mixed for back filling, and surface soil is piled into a turtle-back-shaped mound higher than the ground. According to the after-planting prevention and treatment method, in the attack peak season of the stem rot of passion fruits, the method of spraying a mixed solution of carbendazim, mildothane wettable powder and a prochloraz-manganese chloride complex to the rhizome parts is adopted. According to the method, the stem rot of passion fruits is efficiently prevented and treated in a comprehensive control mode, and good prevention and treatment effects and economic benefits are achieved.